Long-term supplementation of decaffeinated green tea extract does not modify body weight or abdominal obesity in a randomized trial of men at high risk for prostate cancer

Kumar, Nagi B.; Patel, Roshni; Pow‐Sang, Julio M.; Spiess, Philippe E.; Salup, Raoul; Williams, Christopher R.; Schell, Michael J.

doi:10.18632/oncotarget.18858

Cited by 8 publications

(6 citation statements)

References 55 publications

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“…Biomarkers, such as cell proliferation, apoptosis, and angiogenesis in the prostatectomy tissue, did not differ between the treatment arms. The results suggest that further study is required to know prostate cancer preventive activity of Polyphenon ® E. A similar study that was conducted by Kumar et al [35] for one year found that Polyphenon ® E did not affect biomarkers of obesity in 97 men who were at high risk for prostate cancer.…”

Section: Psv Effects On Hpv-unrelated Cancersmentioning

confidence: 56%

Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

et al. 2020

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Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Polyphenon®E was developed as a standardized GTC preparation, which was approved by Food and Drug Administration of US in 2006 as a medication to treat genital warts (Veregen® or sinecatechins). Positive efficacy of Polyphenon®E/sinecatechins/Veregen® (PSV) on anogenital warts has been demonstrated in several epidemiological studies and there have been several case reports to show the clinical effectiveness of PSV. In addition, several studies have provided evidence to suggest that PSV is effective in other human papillomavirus (HPV)-related diseases, although some studies failed to show such effects. Since (−)-epigallocatechin gallate (EGCG) is the major component of PSV, the mechanism of the action of PSV might be deduced from that of EGCG. The microarray analysis of the biopsy samples from the patients suggested that apoptosis induction and the downregulation of inflammation are involved in the mechanism of the action of PSV in the clearance of anogenital warts. Cell-based and animal experiments using PSV also demonstrated effects similar to those elicited by EGCG, explaining how PSV works to induce apoptosis and exert anti-inflammatory actions in HPV-related diseases. Future studies would clarify what kinds of diseases respond effectively to PSV, showing health benefits of GTC and EGCG in humans.

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Section: Psv Effects On Hpv-unrelated Cancersmentioning

confidence: 56%

Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

et al. 2020

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“…The detailed characteristics of the included studies are summarised in Table 1. Studies were published between 1999 and 2021 and were carried out in the USA (28,64,72,83,84,91) , UK (58,61,66) , Finland (49) , the Netherlands (50,52,54,62,78) , Japan (51,56,59,63,69,73) , China (53) , Australia (55) , Taiwan (60,67,75,79,82,86,99) , Thailand (57) , Iran (23,65,80,85,87–89,92,94–97,100,102–105) , Poland (68,70,71) , Lithuania (74,77) , Spain (76) , Brazil (81,93,98) , Pakistan (90) and Mexico (101) . Out of these sixty RCT, five studies (59,66,92,93,99) performed as crossover and fifty-four studies (23,28,49–58,60–65,67–91,94–98,100–105) as parallel.…”

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

The effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a grade-assessed systematic review and dose–response meta-analysis of randomised controlled trials

Asbaghi,

Rezaei Kelishadi,

Larky

et al. 2023

Br J Nutr

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Research indicates that green tea extract (GTE) supplementation is beneficial for a range of conditions, including several forms of cancer, cardiovascular, and liver diseases; nevertheless, the existing evidence addressing its effects on body composition, oxidative stress, and obesity-related hormones is inconclusive. This systematic review and meta-analysis aimed to investigate the effects of GTE supplementation on body composition (body mass [BM], body fat percentage [BFP], fat mass [FM], body mass index [BMI], waist circumference [WC]), obesity-related hormones (leptin, adiponectin, and ghrelin) and oxidative stress (malondialdehyde [MDA], and total antioxidant capacity [TAC]) markers. We searched proper databases, including PubMed/Medline, Scopus, and Web of Science, up to July 2022 to recognize published randomized controlled trials (RCTs) that investigated the effects of GTE supplementation on the markers mentioned above. A random-effects model was used to carry out a meta-analysis. The heterogeneity among the studies was assessed using the I2 index. Among the initial 11286 studies identified from an electronic database search, 59 studies involving 3802 participants were eligible to be included in this meta-analysis. Pooled effect sizes indicated that BM, BFP, BMI, and MDA significantly reduced following GTE supplementation. In addition, GTE supplementation increased adiponectin and TAC, with no effects on FM, leptin, and ghrelin. Certainty of evidence across outcomes ranged from low to high. Our results suggest that GTE supplementation can attenuate oxidative stress, BM, BMI, and BFP, which are thought to negatively affect human health. Moreover, GTE as a nutraceutical dietary supplement can increase TAC and adiponectin.

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“…Thus, it is crucial to search for effective, easy to use, tolerable and economic alternatives. Recently, natural phytotherapeutic supplements are drawing attention, and green tea (from Camellia sinensis) is the most widely used (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Update on the Evaluation of the Anti-Obesity Effect of Green Tea (Camellia sinensis)

Sultane

Cambaza

2020

Clinical and Experimental Health Sciences

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Objective: Obesity is a worldwide rising risk factor for numerous incommunicable illnesses. The most common interventions have been ineffective from a public health perspective. Green tea (Camellia sinensis) seems to be an effective well-known alternative but there is a need to see the most updated and reliable information on the matter. The study aimed to verify how effective is green tea as reductor of human body mass index (BMI). Methods: This meta-analysis reviewed recent controlled randomized trials on the effect of catechin and caffeine in the BMI of adult male and female subjects. The analysis did not include studies including alternative therapies or drugs potentially affecting BMI. The studies presented the quantity of catechin and caffeine (mg). Body mass index and waist circumference were measured before and after the interventions. The trials lasted two to eight months, depending on the study designs. Results and Conclusion: Five studies met the criteria for the current analysis. In one study, the subjects took oral capsules of green tea extract (379mg). Overall, daily doses of catechin varied from 208-1200mg, and caffeine from undetectable levels to 480mg (the tea products were either enriched, capsules or canned with known levels). All showed reduction in body weight, the average BMI reduction was 0.68 kg/m2, and waist circumference was 1,5cm. There was a direct relationship between the concentration of catechin and reduction of BMI, but the BMI appeared to drop to a certain threshold of "optimal" weight, close to values considered as normal weight by the World Health Organization (WHO). There were few cases suggesting abdominal discomfort, but there they did not require additional treatment or hospitalization. Green tea consistently showed ability to reduce weight to a less risky level for health. Yet, it is now necessary to develop dose-response models for its active compounds and clarify the dynamics of the dosage over time. Furthermore, green tea is perhaps more effective in synergy with wellknown methods to maintain or reduce weight, such as balanced diets or physical exercise.

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Long-term supplementation of decaffeinated green tea extract does not modify body weight or abdominal obesity in a randomized trial of men at high risk for prostate cancer

Abstract: Background: Evidence continues to demonstrate the role of obesity in prostate

Cited by 8 publications

References 55 publications

Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

The effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a grade-assessed systematic review and dose–response meta-analysis of randomised controlled trials

Update on the Evaluation of the Anti-Obesity Effect of Green Tea (Camellia sinensis)

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