Long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing BDNF expression in the hippocampus in ovariectomized rats

Wu, Siyang; Ye, Mei; Li, Zhulin; Bu, Shizhong; Zhang, Yisheng

doi:10.1016/j.heliyon.2020.e05180

Cited by 12 publications

(2 citation statements)

References 48 publications

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“…Exposition to light pollution can in fact induce the risk of breast cancer and prostate cancer [46] as well as mood disorders [27]. But it is also known that circadian modifications of melatonin can cause changes in the metabolism of lipids [47].…”

Section: Discussionmentioning

confidence: 99%

Social and Behavioral Rhythms as a Marker of Well-being Indicator in Old Adults Living at Home

Mg¹,

Pintus²,

Zaccheddu³

et al. 2021

Preprint

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Social and behavioral rhythms (SBRs) are related to circadian rhythms well known as central points in the pathophysiology of bipolar disorders. The purpose is to verify in elderly people if having functional SBRs correlated with a positive perception of the quality of life (QoL) and health parameters and if there was an association between dysfunctionality of SBRs and Major Depressive Disorder (MDD). Sample: 141 people aged 65 years (58,9%Female). Each subject was submitted to SBRs Scale (in which higher scores show more dysfunctional SRB); SF-12 for QoL; PHQ-9 for depressive symptoms and underwent blood levels essays including cholesterol and triglyceride. The medical documented lifetime diagnosis including Major Depressive Disorder was taken into account. SBRs Scale score correlated inversely with SF-12 score (r=-0.360, p&lt;0.0001) and positively with PHQ9 (r=0.396, p&lt;0.0001). Lifetime MDD medical diagnosis was associated with a higher score at scale on social rhythms (24.811.9 vs 20.18.0, F=15.848, p&lt;0.0001).The study highlighted, for the first time, that SBRs such as sleep, and nutrition have a role in well-being and that dysregulation of SBRs is related to MDD. Further longitudinal studies with a sufficient number of individuals will have to confirm these data and clarify causal links of the association between QoL and SBRs.

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Section: Discussionmentioning

confidence: 99%

Social and Behavioral Rhythms as a Marker of Well-being Indicator in Old Adults Living at Home

Mg¹,

Pintus²,

Zaccheddu³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Indeed, across all studies, the authors found a significant negative correlation between effect size and percentage of women in the studies, and effect sizes were smaller for studies with a greater proportion of women [ 59 ]. This gender-dependent difference could be due to an interaction between sex hormones and BDNF, as observed in rodent models [ 62 , 63 ]. BDNF is generated in human skeletal muscle in response to exercise, but muscle-derived BDNF is not released into the circulation [ 64 ], suggesting that the links between skeletal muscle and BDNF-induced improvements in hippocampus in response to exercise are indirect.…”

Section: Bdnf: a Key Trophic Signalling Molecule In The Brainmentioning

confidence: 99%

Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders

Nay

Smiles

Kaiser

et al. 2021

IJMS

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As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing the well-being and quality of life of sufferers and their families. In recent decades, due to reduced work-related levels of physical activity, and key research insights, prescribing adequate exercise has become an innovative strategy to prevent or delay the onset of these pathologies and has been demonstrated to have therapeutic benefits when used as a sole or combination treatment. Recent evidence suggests that the beneficial effects of exercise on the brain are related to several underlying mechanisms related to muscle–brain, liver–brain and gut–brain crosstalk. Therefore, this review aims to summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and to highlight the established and potential underlying mechanisms involved in exercise–brain communication and their benefits for physiology and brain function.

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Antidepressant effects of activation of infralimbic cortex via upregulation of BDNF and β-catenin in an estradiol withdrawal model

Chen,

Zhou,

Lai

et al. 2024

Psychopharmacology

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Rationale Clinical and preclinical studies have demonstrated that estradiol withdrawal after delivery is one of important factors involved in the pathogenesis of postpartum depression (PPD). The infralimbic cortex (IL) is related to anxiety and mood disorders. Whether IL neurons mediate PPD is still unclear. Objectives This study was to observe the antidepressant effect and expression of BDNF and β-catenin in IL by allopregnanolone (ALLO) treatment or the selective activation or inhibition of IL neurons using a chemogenetic approach in a pseudopregnancy model of PPD. Methods Administration of estradiol combined with progesterone and the abrupt withdrawal of estradiol simulated the pregnancy and early postpartum periods to induce depression in ovariectomized rats. The relative expression levels of β-catenin and BDNF were observed by western blotting. Results Immobility time was significantly increased in the forced swim test and open-arm movement was reduced in the elevated plus maze test in the estradiol-withdrawn rats. After ALLO treatment, the immobility time were lower and open-arm traveling times higher than those of the estradiol-withdrawn rats. Meanwhile, the expression level of BDNF or β-catenin in the IL was reduced significantly in estradiol-withdrawn rats, which was prevented by treatment with ALLO. The hM3Dq chemogenetic activation of pyramidal neurons in the IL reversed the immobility and open-arm travel time trends in the estradiol-withdrawal rat model, but chemogenetic inhibition of IL neurons failed to affect this. Upregulated BDNF and β-catenin expression and increased c-Fos in the basolateral amygdala were found following IL neuron excitation in model rats. Conclusions Our results demonstrated that pseudopregnancy and estradiol withdrawal produced depressive-like behavior and anxiety. ALLO treatment or specific excitement of IL pyramidal neurons relieved abnormal behaviors and upregulated BDNF and β-catenin expression in the IL in the PPD model, suggesting that hypofunction of IL neurons may be involved in the pathogenesis of PPD.

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Long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing BDNF expression in the hippocampus in ovariectomized rats

Cited by 12 publications

References 48 publications

Social and Behavioral Rhythms as a Marker of Well-being Indicator in Old Adults Living at Home

Social and Behavioral Rhythms as a Marker of Well-being Indicator in Old Adults Living at Home

Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders

Antidepressant effects of activation of infralimbic cortex via upregulation of BDNF and β-catenin in an estradiol withdrawal model

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