Long-term supplementation of high pigmented rice bran oil (Oryza sativa L.) on amelioration of oxidative stress and histological changes in streptozotocin-induced diabetic rats fed a high fat diet; Riceberry bran oil

Posuwan, Juthathip; Prangthip, Pattaneeya; Leardkamolkarn, Vijittra; Yamborisut, Uruwan; Surasiang, Ruethaithip; Charoensiri, Rin; Kongkachuichai, Ratchanee

doi:10.1016/j.foodchem.2012.09.144

Cited by 68 publications

(44 citation statements)

References 30 publications

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“…Antioxidant capacity is reduced to a significant extent in the plasma of STZ-induced diabetic rats, due to the higher requirement of antioxidants in order to regulate the reactive oxygen species (ROS) homeostasis [62] . Nevertheless, enhanced plasma antioxidant capacity in conjunction with reduced lipid peroxidation could be attained by regular ingestion of rich source of antioxidant compounds.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Ahmed

Kumar

Verma

et al. 2014

BMC Complement Med Ther

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BackgroundHypoglycemic and/or anti-hyperglycemic activities have been recorded with numerous plants, many of which are used as traditional herbal treatments of diabetes. Albizzia Lebbeck Benth. stem bark have been used in traditional medicine along with some preliminary reports on its hypoglycemic action. The aim of present investigation was to evaluate the antidiabetic and antioxidant activities of methanolic extract of stem bark of Albizzia Lebbeck Benth. in streptozotocin induced diabetic rats.MethodsThe powdered stem bark of Albizzia Lebbeck Benth.. was extracted with methanol (MeOH) using soxhlation method and subjected to phytochemical analysis. The methanol/dichloromethane extract of Albizzia Lebbeck Benth. (ALEx) was concentrated to dryness using Rotary Evaporator. Diabetes was experimentally induced in the rats by single intraperitoneal administration of Streptozotocin (60 mg/kg). They glycemic control was measured by the blood glucose, glycated heamoglobin and plasma insulin. The oxidative stress was evaluated in the liver and kidney by level of antioxidant markers and various biochemical parameters were assessed in diabetic control and extract treated rats.ResultsStreptozotocin induced diabetic rats depicted the increased blood glucose levels, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c), diminished level of high density lipoprotein cholesterol (HDL-c) level and perturb level of antioxidant markers. Oral administration of MeAL at a concentration of 100, 200, 300 and 400 mg/kg b.w daily for 30 days results a momentous decrease in fasting blood glucose, glycated heamoglobin and enhancement of plasma insulin level as compared with STZ induced diabetic rats. Furthermore, it significantly (p < 0.05) decreased the level of TC, TG, and LDL-c, VLDL-c. While it increases the level of HDL-c to a significant (p < 0.05) level. The treatment also resulted in a marked increase in reduced glutathione, glutathione Peroxidase, catalase and superoxide dismutase and diminished level of lipid peroxidation in liver and kidney of STZ induced diabetic rats. Histopathological studies suggest the diminution in the pancreatic, liver and cardiac muscle damage.ConclusionOur research exertion clearly indicates the considerable antihyperglycemic, antihyperlipidemic, antioxidant & pancreas/renal/hepatic/cardiac protective action of ALEx.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Ahmed

Kumar

Verma

et al. 2014

BMC Complement Med Ther

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“…These results are in harmony with those reported by Al‐Okbi et al (), Araghi et al (), and Abd El‐Wahab et al (). The most important antioxidants in RBO are γ‐oryzanol and tocotrienols (Chotimarkorn, Benjakul, & Silalai, ; Posuwan et al, ). These phytochemicals elicit antioxidant properties either by donating a hydrogen atom to lipid radicals (Siddiqui, Khan, & Siddiqui, ) or by increasing the activities of some antioxidant enzymes such as SOD, CAT, glutathione peroxidase (GPx), nicotinamide adenine dinucleotide phosphate reduced form (NADPH): quinone oxidoreductase, and GPx (Hsieh & Wu, ; Kuhad & Chopra, ; Lee & Kim, ; Son, Rico, Nam, & Kang, ; Weng‐Yew, Selvaduray, Ming, & Nesaretnam, ).…”

Section: Discussionmentioning

confidence: 99%

Rice Bran Oil Improves Insulin Resistance by Affecting the Expression of Antioxidants and Lipid‐Regulatory Genes

Ahmed

Mohamed

Rashed

et al. 2018

Lipids

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The present study investigated the molecular effects of rice bran oil (RBO) on lipid-regulatory genes (sterol regulatory element binding protein-1 [Srebf1] and peroxisome proliferator-activated receptors-α [Ppara]) and the expression of catalase (CAT) and superoxide dismutase (SOD1) genes in insulin-resistant rats. Rats were divided into five groups: animals that received standard diet (control); rats fed standard diet containing RBO as the sole source of fat (RBO); a high-fructose diet (HFD) group, which was further divided into two subgroups: rats fed HFD either for only 1 month (HFD1) or for 2 months (HFD2) and rats fed HFD containing RBO for 1 month; while rats in the last group fed HFD for 30 days then treated with RBO for another 30 days. The HFD induced a state of insulin resistance (IR) as indicated by the hyperinsulinemia and elevated homeostasis model assessment insulin resistance index. Hepatic lipid levels and radical scavenging enzymes were altered by the HFD. Lipid-regulatory genes, Srebf1 and Ppara, were upregulated while Sod1 and Cat were downregulated in insulin-resistant rats. Addition of RBO to the two diet regimens alleviated the disorders of IR to some extent. RBO reduced the hepatic levels of triacylglycerol, malondialdehyde, SREBP, and PPAR-α mRNA. Hepatic SOD and CAT were elevated at gene and protein levels. The HFD induces de novo lipogenesis by upregulating the lipid-regulatory genes resulting in increased serum and hepatic triacylglycerol. Moreover, IR induced by the HFD caused a state of oxidative stress. Supplementation of RBO to fructose-fed rats not only improves insulin resistance but also downregulates lipogenic genes and improves the unbalanced oxidative status.

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“…The results showed that the SC-CO 2 -RBO significantly increased hair density and hair diameter in male subjects with no adverse effects, suggesting a promising use of SC-CO 2 -RBO in the functional cosmetics and pharmaceutical industries 57 . Another study by Posuwan et al 58 evaluated the influence of longterm supplementation of SC-CO 2 extracted RBO from pigmented rice bran Riceberry into streptozotocin-induced diabetic rats. The results showed that the Riceberry bran oil could decrease malondialdehyde and restored superoxide dismutase, catalase, glutathione peroxidase, coenzyme Q and ORAC levels in the rats, as regenerative changes of the pancreas, kidneys, heart and liver were observed 58 .…”

Section: Sc-co 2 Extraction Of Rbomentioning

confidence: 99%

“…Another study by Posuwan et al 58 evaluated the influence of longterm supplementation of SC-CO 2 extracted RBO from pigmented rice bran Riceberry into streptozotocin-induced diabetic rats. The results showed that the Riceberry bran oil could decrease malondialdehyde and restored superoxide dismutase, catalase, glutathione peroxidase, coenzyme Q and ORAC levels in the rats, as regenerative changes of the pancreas, kidneys, heart and liver were observed 58 .…”

Section: Sc-co 2 Extraction Of Rbomentioning

confidence: 99%

Supercritical CO<sub>2</sub> Extraction of Rice Bran Oil –the Technology, Manufacture, and Applications

Sookwong

Mahatheeranont

2017

J. Oleo Sci.

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Long-term supplementation of high pigmented rice bran oil (Oryza sativa L.) on amelioration of oxidative stress and histological changes in streptozotocin-induced diabetic rats fed a high fat diet; Riceberry bran oil

Cited by 68 publications

References 30 publications

RETRACTED ARTICLE: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

RETRACTED ARTICLE: Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Rice Bran Oil Improves Insulin Resistance by Affecting the Expression of Antioxidants and Lipid‐Regulatory Genes

Supercritical CO<sub>2</sub> Extraction of Rice Bran Oil –the Technology, Manufacture, and Applications

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