Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound

Calio, Brian; Lyshchik, Andrej; Li, Jingzhi; Stanczak, Maria; Shaw, Collette; Adamo, Robert D.; Liu, Ji‐Bin; Forsberg, Flemming; Lallas, Costas D.; Trabulsi, Edouard J.; Eisenbrey, John R.

doi:10.1016/j.urology.2018.05.053

Cited by 13 publications

(10 citation statements)

References 18 publications

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“…Although previously treated renal masses were not included in this analysis, prior work has shown CEUS to be an excellent tool for monitoring RCC recurrence after microwave ablation and cryoablation. 26 Our study had several limitations. This retrospective review only assessed the downstream impact of CEUS on clinical treatment and was not able to evaluate the physician decision-making rationale.…”

Section: Discussionmentioning

confidence: 91%

“…Similarly, more conservative and minimally invasive interventional oncologic techniques for treating RCC are also gaining in popularity, particularly in poor surgical candidates. Although previously treated renal masses were not included in this analysis, prior work has shown CEUS to be an excellent tool for monitoring RCC recurrence after microwave ablation and cryoablation 26 …”

Section: Discussionmentioning

confidence: 99%

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Effects of Contrast‐Enhanced Ultrasound of Indeterminate Renal Masses on Patient Clinical Management

Eisenbrey

Kamaya

Gummadi

et al. 2020

J of Ultrasound Medicine

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Objectives-To investigate the long-term impact of contrast-enhanced ultrasound (CEUS) on the treatment of patients with indeterminate renal masses. Methods-In this retrospective study, consecutive charts of all patients receiving renal CEUS at 1 of 2 academic medical centers between January 1, 2014, and December 31, 2018, were reviewed. Patients were included in the study if they had documented chronic renal disease (estimated glomerular filtration rate < 60 mL/min/1.73 m 2) or prior nephrectomy and received CEUS for a previously untreated renal mass. Results-A total of 215 lesions in 157 patients were used for analysis. Contrastenhanced ultrasound provided a final treatment recommendation in 71.6% of lesions (154 of 215). Of these 154 lesions, 7.8% (12 of 154) were lost to followup despite CEUS suggesting malignancy; 15.6% (24 of 154) went directly for surgical intervention, with malignancy confirmed by pathologic results in 87.5% (21 of 24) of these cases; and the remaining 76.6% (118 of 154) were deemed benign and required no additional follow-up. Of the 118 lesions diagnosed by CEUS as benign and requiring no follow-up, none showed evidence of later renal cell carcinoma development and, only 5.1% (6 of 118) of the total population was referred for further cross-sectional imaging of the mass in question. In 28.4% of all lesions (61 of 215), CEUS resulted in a recommendation for surveillance imaging at a 6-to 12-month interval, and less than 10% (6 of 61) of these underwent additional cross-sectional imaging within the recommended 6 months after CEUS. Conclusions-These findings highlight the impact of CEUS on clinical treatment of indeterminate renal masses, including reducing the use of the potentially nephrotoxic contrast agents and providing a direct pathway to transplant. Key Words-contrast-enhanced ultrasound; imaging; renal cell carcinoma; renal masses; ultrasound I ncidentally detected renal masses are extremely common, affecting up to 14% of the population. 1 Although most masses are simple cysts and require no further follow-up, a substantial

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of Contrast‐Enhanced Ultrasound of Indeterminate Renal Masses on Patient Clinical Management

Eisenbrey

Kamaya

Gummadi

et al. 2020

J of Ultrasound Medicine

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“…46 As a result, 3D CEUS has been studied in the early determination of tumor response to local treatment. [47][48][49] In thermal ablation of liver tumors, 3D CEUS has been examined as a means of guiding and confirming the adequacy of the procedure. A research group investigated the effectiveness of ablation when intra-procedural 3D CEUS was used to confirm technical success and guide further need for ablation.…”

Section: D Ceus In Lrt Response Monitoringmentioning

confidence: 99%

“…46 As a result, 3D CEUS has been studied in the early determination of tumor response to local treatment. 47 48 49…”

Section: D Ceus In Lrt Response Monitoringmentioning

confidence: 99%

State of the Art: Contrast Enhanced 4D Ultrasound to Monitor or Assess Locoregional Therapies

Tantawi

Shamimi-Noori

Shaw

et al. 2022

Digestive Disease Interventions

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Locoregional therapies (LRTs) are an essential management tool in the treatment of primary liver cancers or metastatic liver disease. LRTs include curative and palliative modalities. Monitoring treatment response of LRTs is crucial for maximizing benefit and improving clinical outcomes. Clinical use of contrast-enhanced ultrasound (CEUS) was introduced more than two decades ago. Its portability, cost effectiveness, lack of contraindications and safety make it an ideal tool for treatment monitoring in numerous situations. Two-dimensional dynamic CEUS has been proved to be equivalent to the current imaging standard in the guidance of LRTs, assessment of their adequacy, and detection of early tumor recurrence. Recent technical advances in ultrasound transducers and image processing have made 3D CEUS scanning widely available on most commercial ultrasound systems. 3D scanning offers a broad multiplanar view of anatomic structures, overcoming many limitations of two-dimensional scanning. Furthermore, many ultrasound systems provide real-time dynamic 3D CEUS, also known as 4D CEUS. Volumetric CEUS has shown to perform better than 2D CEUS in the assessment and monitoring of some LRTs. CEUS presents a valid alternative to the current imaging standards with reduced cost and decreased risk of complications. Future efforts will be directed toward refining the utility of 4D CEUS through approaches such as multi-parametric quantitative analysis and machine learning algorithms.

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“…The combination of 2D-CEUS and 3D-CEUS had sensitivity of 100%, specificity of 91.7%, and accuracy of 92.9% in predicting the therapeutic response to RFA, suggesting that CEUS can be an alternative means to in clinical follow-up assessment of these patients [22]. Similarly, studies on RFA of renal tumors revealed high sensitivity (> 80%) and specificity (> 95%) of CEUS, performed within one month post-ablation, in detecting residual lesions or recurrences [23][24][25][26][27]. An example of this work is shown in figure 3.…”

Section: Ablation Response Assessmentmentioning

confidence: 99%

Recent Advances in Microbubble-Augmented Cancer Therapy

Tantawi¹,

Liu²,

Eisenbrey³

2020

Advanced Ultrasound in Diagnosis and Therapy

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Contrast-enhanced ultrasound (CEUS) applications in cancer management have expanded over the past two decades.Through detection of vascularization and perfusion changes, CEUS provides a potentially reliable means of early prediction of response to different cancer therapies including systemic chemotherapy and locoregional therapies. Ultrasound-induced cavitation of contrast agents has a range of effects on the surrounding microenvironment. These effects can be manipulated to sensitize the tumors to radio-and chemotherapy, as well as achieve targeted delivery through drug-loaded contrast agents. Newer forms of drug carriers are being developed with improved drug-carrying capacity and tissue penetration. This review aims at providing a synopsis of the latest developments in CEUS' use in oncologic therapy. While the majority of work described in this review is still in the pre-clinical phases, results have been encouraging and show potential translational benefit for cancer patients in the near future.

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Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound

Cited by 13 publications

References 18 publications

Effects of Contrast‐Enhanced Ultrasound of Indeterminate Renal Masses on Patient Clinical Management

Effects of Contrast‐Enhanced Ultrasound of Indeterminate Renal Masses on Patient Clinical Management

State of the Art: Contrast Enhanced 4D Ultrasound to Monitor or Assess Locoregional Therapies

Recent Advances in Microbubble-Augmented Cancer Therapy

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