Long‐term survival after blood transfusion

Abstract

Receipt of a blood transfusion can be used as a descriptive epidemiologic index of morbidity in the general population, as it is independently predictive of mortality, adding to the predictive value of age, gender, and previous hospitalization. There is a dose-response relationship between the amount of blood components received and a reduction in the subsequent length of survival. However, when a county's entire population is studied, posttransfusion mortality due to underlying disease is substantially lower than that previously reported in look-back investigations.

September 2007 Update on EORTC Guidelines and Anemia Management with Erythropoiesis-Stimulating Agents

“…[9,10]. Furthermore, Vamvakas and Taswell quantified the association between blood transfusion and mortality in a more broadly based U.S. population, and found a dose-response relationship between the number of blood transfusions and a subsequent shorter length of survival (Table 2) [11]. Concern has also been expressed about the quality of stored blood and observations of negative outcomes in transfused patients.…”

Induced hypotension with epidural/general anesthesia reduces transfusion in radical prostate surgery

“…One study demonstrated that patients with colon cancer who received a blood transfusion had twice the infection rate of those who were not transfused (12% vs 25%). 26 Patients who receive blood transfusions have one-and ten-year mortality rates of 24% and 52 % respectively. 27 Irrespective of these risks, most patients would prefer not to receive blood if at all possible for many reasons, and in view of the uncertainty about the short-and long-term effects of blood transfusion, we should make every effort to avoid this intervention.…”

Intraoperative blood salvage reduces the requirements for allogenic blood transfusion and transfusion related inflammatory response in abdominal aortic aneurysm surgery: Blood transfusion and abdominal aortic aneurysm surgery

“…Carless i saradnici su 2010. godine analizirali 75 studija koje ispituju efikasnost intraoperativnog spašavanja krvi i to u ortopediji (36 studija), kardiohirurgiji (33 studije) i vaskularnim procedurama (6 studija) i doneli zaključak da se njegovom upotrebom smanjuje potreba za transfuzijom donorske krvi, kao i to da ne izaziva nastanak ikakvih neželjenih događaja 10 . Pored definisanih neželjenih efekata alogene krvi, postoje i oni nedefinisani koji se odnose na dugoročne efekte transfuzije alogene krvi na mortalitet i morbiditet 11,12,13 . Ispitivano je dugoročno preži-vljavanje 1915 bolesnika koji su imali neku kardiohirušku intervenciju, gde je 649 bolesnika primilo alogenu transfuziju i došlo se do zaključka da je taj broj bolesnika imao kraće preživljavanje za 5 godina u proseku u odnosu na one koji nisu primali donorsku krv 14 .…”