Long-Term Survival After Report Resection of Pulmonary Metastases from Hepatocellular Carcinoma: Report of Two Cases

Nakamura, Tõru; Kimura, Taizo; Umehara, Yasuhiko; Suzuki, Kenji; Okamoto, Kazuya; Okumura, Toshikatsu; Morizumi, Sei; Kawabata, Toshiki; Komiyama, Akira

doi:10.1007/s00595-005-3022-7

Cited by 14 publications

(9 citation statements)

References 12 publications

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“…43 Thus, liver resection should be aggressively pursued for advanced HCC. In general, extrahepatic metastasis of HCC portends a dismal prognosis; however, there are sporadic reports of aggressive surgical resection for metastases to the adrenal gland, 44 lung, 45 and lymph nodes. 46,47 …”

Section: Surgical Treatments For Advanced Hccmentioning

confidence: 97%

Surgical treatment of hepatocellular carcinoma

Hasegawa

Kokudo

2009

Surg Today

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Local tumor control is still the most important consideration in the treatment of hepatocellular carcinoma (HCC). Surgical treatments, including liver resection and liver transplantation are, and will remain, the first-line therapeutic strategies for local control in patients with primary HCC. Although aggressive liver resection is often performed for advanced HCC in patients with a large tumor, multiple tumors, or tumors with vascular invasion, liver transplantation is the preferred option, after taking into consideration age and tumor-related factors, when there is poor liver functional reserve. Preventing deterioration in liver function is the second priority in the treatment of HCC. When performing liver resection, extensive removal of noncancerous liver parenchyma during lobectomy or hemihepatectomy, should be avoided as much as possible. Anatomic resection, which refers to systematic elimination of the main tumor with its minute metastases, preserves liver function and is highly recommended. A treatment algorithm based on published evidence is now available, which helps us decide on the most suitable therapeutic option for individual patients, depending on the tumor characteristics and liver functional reserve.

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Section: Surgical Treatments For Advanced Hccmentioning

confidence: 97%

Surgical treatment of hepatocellular carcinoma

Hasegawa

Kokudo

2009

Surg Today

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“…Lung is the most common site for extrahepatic recurrence of HCC. The incidence of pulmonary metastasis after hepatic resection for HCC ranges from 37% to 58% [6]. Therefore, to reduce the pulmonary metastasis could ameliorate the prognosis of HCC.…”

Section: Introductionmentioning

confidence: 99%

TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular carcinoma in mice model

Dong

et al. 2012

J Exp Clin Cancer Res

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Background: Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma (HCC) is till unknown. Methods: We detected the in vitro and in vivo expression levels of TGF β1/Smads by Real-time PCR and Western blot in MHCC97-H and MHCC97-L cell lines, which are HCC cell lines and have higher and lower pulmonary metastatic potential respectively.

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“…In our patient, surgical resections were chosen with the consideration that curative resection could be performed. Thirteen patients (including ours) who underwent repeated curative pulmonary resections for the recurrence of metastatic lung cancer from HCC have been reported ,,. O'Suilleabhain et al reported the successful treatment, by resection in sequence, of metastases originating from HCC in three organs (brain, lung, and spleen).…”

Section: Discussionmentioning

confidence: 87%

Three pulmonary resections for metastatic lung cancer from hepatocellular carcinoma

Mizuno

Iwata

Matsumoto

et al. 2007

J Hepatobiliary Pancreat Surg

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We describe a patient who underwent pulmonary resection three times for metastatic lung cancer from hepatocellular carcinoma (HCC). A 56-year-old man, who had a past history of right hepatic lobectomy for HCC, was referred to our department with an abnormal finding on chest computed tomography (CT). Chest CT showed three abnormal shadows, in the right upper lobe (S3b), right middle lobe (S5), and right lower lobe (S10), respectively, and there was no evidence of intrahepatic recurrence. He underwent surgical resections (right upper lobectomy and partial resections) for the metastatic lung cancer from HCC. Subsequently, 12 and 16 months after the first pulmonary resection, metastatic lung cancer recurred, in right S6 and S9, respectively. Because there was no evidence of intrahepatic recurrence and because of the feasibility of curative resection, we performed partial pulmonary resections. He had no postoperative morbidity, and is alive with no evidence of disease 60 months after the first pulmonary resection. Twelve cases of repeat pulmonary resections for metastatic lung cancer from HCC have been reported in the literature, and the authors of these reports described that repeated pulmonary resections for metastatic lung cancer from HCC resulted in long-term survival. Repeat pulmonary resections for metastatic lung cancer from HCC can be an effective treatment for patients with such metastases.

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Long-Term Survival After Report Resection of Pulmonary Metastases from Hepatocellular Carcinoma: Report of Two Cases

Cited by 14 publications

References 12 publications

Surgical treatment of hepatocellular carcinoma

Surgical treatment of hepatocellular carcinoma

TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular carcinoma in mice model

Three pulmonary resections for metastatic lung cancer from hepatocellular carcinoma

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