Long-term survival after successful inhospital cardiac arrest resuscitation

Bloom, Heather; Shukrullah, Irfan; Cuellar, Jose; Lloyd, Michael S.; Dudley, Samuel C.; Zafari, A. Maziar

doi:10.1016/j.ahj.2007.02.011

Cited by 72 publications

(61 citation statements)

References 35 publications

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“…It was reported that ventricular tachycardia/ventricular fibrillation was independently associated with survival to hospital discharge in patients with in-hospital and out-of-hospital CA. 16 In the present study, however, the first documented rhythm was not associated with survival. This might have been due to the relatively small number of patients (n=50, 47.6%) with out-of-hospital CA in the present study.…”

Section: Other Potential Factors Predicting Survival After Pcpscontrasting

confidence: 72%

“…The overall survival rate of patients who experienced in-hospital CA, however, remains unsatisfactory. 16 It was reported that cardiopulmonary resuscitation (CPR) assisted with ACLS improved the survival rate of in-hospital CA patients. 7, 15 Based on the present findings, we recommend that immediate PCPS should be considered when in-hospital CA patients with cardiovascular disease do not response to ACLS.…”

Section: Other Potential Factors Predicting Survival After Pcpsmentioning

confidence: 99%

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Predictive Score for Survival After Percutaneous Cardiopulmonary Support in Cardiovascular Disease Patients

Shirakabe

Nozaki

Hata

et al. 2013

Circ J

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2064SHIRAKABE A et al. Circulation JournalOfficial Journal of the Japanese Circulation Society http://www. j-circ.or.jp the development of new devices and improvements in intensive care, a disappointingly high rate of short-term mortality is still observed. To date, there have been no guidelines established for the use of PCPS in patients with cardiovascular disease, although the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care state that it should be used for patients with disease of class IIb and with evidence level C. 5 Furthermore, the predictive factors for the survival of patients undergoing PCPS are also unclear. Because the extended use of this PCPS procedure, which requires highly specialized staff and equipment, might increase hospitals costs and affect resource utilization, ercutaneous cardiopulmonary support (PCPS) has recently become a common procedure because of its portability, rapid priming, and ease of handling. In 1992 the indications for PCPS were expanded to include medical emergency cases, based on the results of a multi-institutional study. 1 Therefore, PCPS has been used for severe cardiogenic shock or circulatory collapse complicating acute myocardial infarction, severe heart failure, fulminant myocarditis (FM), pulmonary thromboembolism, and refractory ventricular arrhythmia.

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Section: Other Potential Factors Predicting Survival After Pcpscontrasting

confidence: 72%

Section: Other Potential Factors Predicting Survival After Pcpsmentioning

confidence: 99%

Predictive Score for Survival After Percutaneous Cardiopulmonary Support in Cardiovascular Disease Patients

Shirakabe

Nozaki

Hata

et al. 2013

Circ J

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“…21 The GOS-E provides a global measure of function on an 8-level scale from death (1) to upper good recovery (8) and can be administered by proxy or direct interview with the patient. Domains such as self-care, mobility, return to work, relationship, and social and leisure activities are considered.…”

Section: Outcome Measuresmentioning

confidence: 99%

“…6 Despite this finding, there are concerns that many survivors are substantially disabled with poor long-term quality of life. 7,8 Given that there is significant investment in improving the emergency response to OHCA patients 9,10 and reported improvements in short-term survival outcomes, the long-term neurological state and quality of life of survivors is of growing significance.…”

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confidence: 99%

Quality of Life and Functional Outcomes 12 Months After Out-of-Hospital Cardiac Arrest

et al. 2015

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Background-Out-of-hospital cardiac arrest (OHCA) is a significant global health problem. There has been considerable investment in improving the emergency medical response to OHCA, with associated improvements in survival. However, concern remains that survivors have a poor quality of life. This study describes the quality of life of OHCA survivors at 1-year postarrest in Victoria, Australia. Methods and Results-Adult OHCA patients who arrested between 2010 and 2012 were identified from the Victorian Ambulance Cardiac Arrest Registry. Paramedics attended 15 113 OHCA patients of which 46.3% received an attempted resuscitation. Nine hundred and twenty-seven (13.2%) survived to hospital discharge of which 76 (8.2%) died within 12 months. Interviews were conducted with 697 (80.7%) patients or proxies, who were followed-up via telephone interview, including the Glasgow Outcome Scale-Extended, the 12-item short form health survey, and the EuroQol. The majority (55.6%) of respondents had a good recovery via the Glasgow Outcome Scale-Extended≥7 (41.1% if patients who died postdischarge were included and nonrespondents were assumed to have poor recovery

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“…While cardiopulmonary resuscitation for victims of cardiac arrest succeeds in restoring spontaneous circulation in about 70,000 patients per year in the US 7,8 at least 60% of these patients subsequently die in the hospital as a result of extensive brain damage and only 3-10% of resuscitated patients can resume their former lifestyles 9,10 . Clearly, understanding the mechanisms that lead to brain damage following global brain ischemia and designing therapeutic interventions to minimize neurologic trauma is of critical importance.…”

Section: Introductionmentioning

confidence: 99%

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

Sanderson

Wider

2013

JoVE

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Cardiac arrest followed by resuscitation often results in dramatic brain damage caused by ischemia and subsequent reperfusion of the brain. Global brain ischemia produces damage to specific brain regions shown to be highly sensitive to ischemia 1 . Hippocampal neurons have higher sensitivity to ischemic insults compared to other cell populations, and specifically, the CA1 region of the hippocampus is particularly vulnerable to ischemia/reperfusion 2 .The design of therapeutic interventions, or study of mechanisms involved in cerebral damage, requires a model that produces damage similar to the clinical condition and in a reproducible manner. Bilateral carotid vessel occlusion with hypotension (2VOH) is a model that produces reversible forebrain ischemia, emulating the cerebral events that can occur during cardiac arrest and resuscitation. We describe a model modified from Smith et al. (1984) 2 , as first presented in its current form in Sanderson, et al. (2008) 3 , which produces reproducible injury to selectively vulnerable brain regions [3][4][5][6] . The reliability of this model is dictated by precise control of systemic blood pressure during applied hypotension, the duration of ischemia, close temperature control, a specific anesthesia regimen, and diligent post-operative care. An 8-minute ischemic insult produces cell death of CA1 hippocampal neurons that progresses over the course of 6 to 24 hr of reperfusion, while less vulnerable brain regions are spared. This progressive cell death is easily quantified after 7-14 days of reperfusion, as a near complete loss of CA1 neurons is evident at this time.In addition to this brain injury model, we present a method for CA1 damage quantification using a simple, yet thorough, methodology. Importantly, quantification can be accomplished using a simple camera-mounted microscope, and a free ImageJ (NIH) software plugin, obviating the need for cost-prohibitive stereology software programs and a motorized microscopic stage for damage assessment. Video LinkThe video component of this article can be found at

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Long-term survival after successful inhospital cardiac arrest resuscitation

Abstract: Background-Little is known about long-term outcomes of patients who survive inhospital cardiac arrest.

Cited by 72 publications

References 35 publications

Predictive Score for Survival After Percutaneous Cardiopulmonary Support in Cardiovascular Disease Patients

Predictive Score for Survival After Percutaneous Cardiopulmonary Support in Cardiovascular Disease Patients

Quality of Life and Functional Outcomes 12 Months After Out-of-Hospital Cardiac Arrest

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

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