Long-term survival curve of methicillin-resistant Staphylococcus aureus on clinical contact surfaces in natural-like conditions

Petti, Stefano; Giusti, Maria De; Moroni, Catia; Polimeni, Antonella

doi:10.1016/j.ajic.2011.11.020

Cited by 18 publications

(8 citation statements)

References 12 publications

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“…Therefore, the immediate effectiveness of the experimental protocol was not measured. It is possible that organisms detected after three-months were not eradicated at baseline since S. aureus can exhibit long-term survival on surfaces (63, 64). However, host recolonization and replenishment of the environment over time is also possible.…”

Section: Discussionmentioning

confidence: 99%

Comparative Effectiveness Study of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence

Hower

D’Orazio

Gándara

et al. 2020

Preprint

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BACKGROUND: Recurrent skin and soft tissue infections (SSTI) caused by Community-Associated Methicillin-Resistant (CA-MRSA) or Methicillin-Sensitive Staphylococcus aureus (CA-MSSA) present treatment challenges. OBJECTIVES: Can an evidence-based intervention (CDC Guidelines, topical decolonization, surface decontamination) reduce SSTI recurrence, mitigate household contamination and transmission, and improve patient-reported outcomes? DESIGN: Randomized trial SETTING: Community settings PARTICIPANTS: Participants (n=186) with confirmed MRSA(+)/MSSA(+) SSTIs and household members. INTERVENTION Community Health Workers/Promotoras conducted home visits and provided participants with instructions, a five-day supply of mupirocin for nasal application, chlorhexidine for body cleansing, and disinfecting wipes for household cleaning (EXP) versus Usual Care (UC). MEASUREMENTS: Primary outcome was six-month SSTI recurrence recorded in electronic health records (EHR). Home visits (months 0/3) and telephone assessments (months 0/1/6) collected self-report data. Surveillance culture swabs (nares, axilla, groin) were obtained from index patients and participating household members. Secondary outcomes included household surface contamination, household member colonization and transmission, quality of life and satisfaction with care. RESULTS: Among patients with SSTIs (n=421), 44.2% were MRSA(+)/MSSA(+); an intent-to-treat analyses (n=186) demonstrated no significant differences in SSTI recurrence (OR: 1.4, 95% CI: 0.51-3.5). Among the enrolled cohort (n=119), there were no significant SSTI recurrence effects (OR=1.14, 95% CI=0.35-3.6). EXP participants showed reduced but non-significant colonization rates. There were no differential reductions in household member transmission or in reductions in proportions of households with >1 contaminated surface. Mupirocin resistance did not increase. No significant improvements for patient-reported outcomes were seen. LIMITATIONS: A lower-than-predicted six-month recurrence rate may have limited the ability to detect effects. CONCLUSION: This intervention did not reduce clinician-reported MRSA/MSSA SSTI recurrence. No differences were observed for household members decolonization or household surfaces decontamination.

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Section: Discussionmentioning

confidence: 99%

Comparative Effectiveness Study of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence

Hower

D’Orazio

Gándara

et al. 2020

Preprint

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“…After treating the patients under a revised IC protocols, including single use of barrier covers, MRSA was not detected on the surfaces of the dental operatory, and no HAI occurred during hospitalization. MRSA long-term persistence in a simulation of dental operative conditions up to 4 months suggests that the risk for MRSA diffusion on CCSs is high in the dental office [90]. In fact, hydrophobic microorganisms adhere relatively easily to medical devices and CCSs constructed from hydrophobic materials (rubber, silicon, stainless steel, teflon, etc.…”

Section: Environmental Contamination In Dental Settingmentioning

confidence: 99%

Infection Control in Dentistry and Drug-Resistant Infectious Agents: A Burning Issue. Part 2

Barenghi¹,

Barenghi²,

Blasio³

2020

Surgical Infections - Some Facts

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We showed that antibiotic-resistant bacterial infections inside of dental settings are relevant. Here, we have focused on the limited awareness on infection prevention guidelines, and the lapses and errors during infection prevention, which sustain the evidence of possible reservoirs of antibiotic-resistant bacterial infections in humans (dental staff and patients) and on dental items or in the environment. We chose Staphylococci and Enterobacteriaceae as markers since they are considered as prioritized bacteria according to antibiotic resistance pressure, and the data are available on their virulence factors and for dental settings. For better dental patient and healthcare personnel safety, we need to improve knowledge on bioburden and biofouling, based also on molecular biological methods, and education and training initiatives to limit the hazards in surgical dental settings and to sustain accreditation survey.

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“…In the ICU, it's required that HCWs should wash and clean hands before and after contact with each patient, since each HCW spent 27 min with each patient per visit, so the required hand cleaning frequency was about 4.4 times per hour during healthcare visit. However the compliance with hand hygiene is poor [29,30]. We assumed HCWs would clean their hands after 42% of healthcare visits with patients, which is the average hand hygiene compliance rate observed in 12 studies conducted in ICUs (Additional file 1: Part A.…”

Section: Model Interventionmentioning

confidence: 99%

Quantifying the relative impact of contact heterogeneity on MRSA transmission in ICUs - a modelling study

Lei

Jones

2020

BMC Infect Dis

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Background: An efficient surface cleaning strategy would first target cleaning to surfaces that make large contributions to the risk of infections. Methods: In this study, we used data from the literature about methicillin-resistant Staphylococcus aureus (MRSA) and developed an ordinary differential equations based mathematical model to quantify the impact of contact heterogeneity on MRSA transmission in a hypothetical 6-bed intensive care unit (ICU). The susceptible patients are divided into two types, these who are cared by the same nurse as the MRSA infected patient (Type 1) and these who are not (Type 2). Results:The results showed that the mean MRSA concentration on three kinds of susceptible patient nearby surfaces was significantly linearly associated with the hand-touch frequency (p < 0.05). The noncompliance of daily cleaning on patient nearby high-touch surfaces (HTSs) had the most impact on MRSA transmission. If the HTSs were not cleaned, the MRSA exposure to Type 1 and 2 susceptible patients would increase 118.4% (standard deviation (SD): 33.0%) and 115.4% (SD: 30.5%) respectively. The communal surfaces (CSs) had the least impact, if CSs were not cleaned, the MRSA exposure to Type 1 susceptible patient would only increase 1.7% (SD: 1.3). The impact of clinical equipment (CE) differed largely for two types of susceptible patients. If the CE was not cleaned, the exposure to Type 1 patients would only increase 8.4% (SD: 3.0%), while for Type 2 patients, it can increase 70.4% (SD: 25.4%). Conclusions:This study provided a framework to study the pathogen concentration dynamics on environmental surfaces and quantitatively showed the importance of cleaning patient nearby HTSs on controlling the nosocomial infection transmission via contact route.

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Long-term survival curve of methicillin-resistant Staphylococcus aureus on clinical contact surfaces in natural-like conditions

Cited by 18 publications

References 12 publications

Comparative Effectiveness Study of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence

Comparative Effectiveness Study of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence

Infection Control in Dentistry and Drug-Resistant Infectious Agents: A Burning Issue. Part 2

Quantifying the relative impact of contact heterogeneity on MRSA transmission in ICUs - a modelling study

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