Long term survival of patients with gastric cancer treated with adjuvant radio-chemotherapy: proposal of a prognostic index with implication for treatment modification

Liu, Junliang; Ahmed, Shahida

doi:10.15761/orr.1000109

Cited by 3 publications

(3 citation statements)

References 19 publications

(22 reference statements)

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“…There are evidences supporting that clinical researches are exploring the benefits of giving chemotherapy as adjuvant therapy for surgery to destroy remaining cancer cells 37 . In recent analyses of definitive surgery followed by adjuvant radio chemotherapy (5-Fu/leucovorin LV regimens) for patients with gastric cancer, Liu and Ahmed reported that 59.3% (48/81) patients survived >3 years, 18.5% (15/81) patients survived 5 or more years 38 . Eighteen out of 81(22.2%) patients are still alive with a medium survival of 142 months (57-196 months).…”

Section: Discussionmentioning

confidence: 99%

Treatment of Patients With Advanced Cancer Following Chemotherapy and Traditional Medicine - Long Term Follow Up of 75 Cases

Zhu

2018

UJPR

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Objective: Traditional systems of medicine all over the world even traditional medicine and cancer have been using plants and plants products for therapeutic intention. The purpose of these retrospective trials is to assess the clinical efficacy of chemotherapy in conjunction with TCM for a broad variety of cancers. Methods: 75 patients with available cancers were concluded in the study during September1993 -May 2018.The sex ratio of male: female was 50:25 respectively. The mean age at onset was 46.9 years( range 10-79 years. All patients were treated with different dosage of various chemotherapy in combination with TCM or traditional medicine alone. The basic chemotherapeutic regimen consisted of vincristine( VCR, 1-2 mg/week)、 cyclophosphamide( CTX, 200-1, 000mg/ week), mitomycin C(MMC, 2-4mg/week) and 5-fluorouracil( 5-Fu,250-500mg/ day). The detail prescription of TCM varied among a broad variety of carcinomas. The criteria of complete remission( CR) and/or partial remission( PR) is according to the rules where physicians have in common with in clinics. In 75 cases, the CR was obtained in 33(44%) advanced cancers, a short CR in 11(14.7%) cases, PR in 25 (33.3%) cancers, stable disease in 6 cases.. The crude herbs consisted of sargassum, tangle, Oyster(mussels), Poria cocos, Ophiopogon japonicus, Prunella vulgaris, Taraxacum, Scrophularia ningpoensis, Cremastra appendiculata, Trichosanthes Kirilowii, Sophora subprostrata, Houttuynia cordata, Scutellaria barbata d. don and Oldenlandia diffusa roxb. Results: Among those long-term survivors, 31 carcinomas obtained in disease-free survival over 5 years, 20 cancers were survival over 10 years, the longest four patients over 25 years. Conclusion: In this study, it was experienced that a CR was a pivotal influencing factor in those longest survival patients, and traditional medicine was also recommended. Down regulating oncogenic receptors may be useful paradigm and perspective in currently the third line setting of clinical target therapy and in rendering our better understanding of cancer biology. Cite this article-George Zhu. Treatment of patients with advanced cancer following chemotherapy and traditional medicine -long term follow up of 75 cases. 16 CODEN (USA): UJPRA3 leukocytosis with development of retinoic acid syndrome, an important adverse reaction during treatment of APL. Thus, Tamibarotene demonstrated more efficacy in both untreated APL patients and relapsed who have been treated ATRA and chemotherapy, especially as novel strategy in relapsed APL in Japan and others 74-76 . This is encouraging perspective.

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Section: Discussionmentioning

confidence: 99%

Treatment of Patients With Advanced Cancer Following Chemotherapy and Traditional Medicine - Long Term Follow Up of 75 Cases

Zhu

2018

UJPR

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“…The relative benefits of these different drugs, alone or in combination, are unclear [36].There are evidence supporting that clinical researches are exploring the benefits of giving chemotherapy as adjuvant therapy for surgery to destroy remaining cancer cells [37]. In recent analyses of definitive surgery followed by adjuvant radio chemotherapy(5-Fu/leucovorin LV regimens) for patients with gastric cancer, Liu and Ahmed [38] reported that 59.3%(48/81) patients survived > 3 years,18.5% (15/81) patients survived 5 or more years. Eighteen out of 81(22.2%) patients are still alive with a medium survival of 142 months (57-196 months).…”

Section: Discussionmentioning

confidence: 99%

Clinical prolonged follow up of patients with advanced cancers after chemotherapy with traditional medicine (78 cases)

Zhu¹

2018

Trends Cancer Res Chemother

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Objective: Traditional systems of medicine all over the world even traditional medicine and cancer have been using plants and plants products for therapeutic intention. The purpose of this retrospective trials is to assesses the clinical efficacy of chemotherapy in conjunction with TCM for a broad variety of cancers.Methods: 78 patients with available cancers were concluded in the study during September1993 -May2018.The sex ratio of male: female was 53:25 respectively. The mean age at onset was 46.9 years (range 10-79 years). All patients were treated with different dosage of various chemotherapy in combination with TCM or traditional medicine alone. The basic chemotherapeutic regimen consisted of vincristine (VCR,1-2mg/week), cyclophosphamide (CTX, 200-1,000mg / week), mitomycin C (MMC, 2-4mg/week) and 5-fluorouracil (5-Fu,250-500mg/day). In addition, according to patient condition, the additional drug doxorubicin (ADM,20mg/week) in lymphoma and metastatic breast cancer, demethylcantharidin in liver cancer and cisplatin (DDP) or interleukin-2(PHA) or gefitinib in lung cancer. The detail prescription of TCM varied among a broad variety of carcinomas (see full text case reports). The criteria of complete remission (CR) and/or partial remission (PR)is according to the rules where physicians have in common with in clinics. Results:In 78 cases, the CR was obtained in 33(42.3%) advanced cancers, a short CR in 12(15.4%) cases, PR in 27 (34.6%) cancers, Stable disease in 6 cases. In differential types of 20 patients over ten years, lymphoma occupied 8 cases (40%). As to approach to the schedule of drug administration,16 lymphoma obtained CR via COMA (CTX, VCR, MMC, ADM) regimen and TCM or antibiotics and immunotherapy. Five advanced gastric cancer were successfully treated using MFC and cinobufacini/cantharidin,and TCM. In follow up, one HCC accompanied with colon polyps obtained CR via hepatectomy and targeting oncogenic receptor tyrosine kinase inhibitor sorafenib. Among two lung cancer, one female with metastatic lung cancer was given targeting oncogenic receptor EGFR gefitinib therapy after the combination chemotherapy, which was stable disease for 8+months.CR can also be achieved in one advanced cholangicarcinoma and one advanced gallbladder cancer through major protocol of TCM and the addition of small dosage of chemotherapy. Thyroid cancer was placed on the primary use of TCM. The crude herbs consisted of sargassum, tangle, Oyster (mussels), Poria cocos, Ophiopogon japonicus, Prunella vulgaris, Taraxacum, Scrophularia ningpoensis, Cremastra appendiculata, Trichosanthes Kirilowii, Sophora subprostrata, Houttuynia cordata, Scutellaria barbata d. don and Oldenlandia diffusa roxb. Among those long-term survivors,31 carcinomas obtained in disease-free survival over 5years,20 cancers were survival over 10years, the longest four patients over 25 years. Conclusion:In this study, I experienced that a CR was a pivotal influencing factor in those longest survival patients, and traditional medicine was also recommended. Do...

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“…But unfortunately, up to 50% of patients have experienced tumor recurrence overthe first five years, which indicates that the results of surgery alone have been insufficient [14]. Additionally, radiation therapy and traditional postoperative chemotherapy have failed to work effectively in the case of GIST [15,16]. On the other hand, the treatment of GIST has been revolutionized by the introduction of smallmolecule kinase inhibitors that specifically target the underlying pathogenic mutant kinase.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of an Advanced Stage Gastrointestinal Stromal Tumor Successfully Treated by Surgery and Imatinib

Meligy¹,

ALakkad²,

Almahameed³

et al. 2022

AJMAH

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Background: The most prevalent gastrointestinal sarcoma is a gastrointestinal stromal tumor.It is frequently misdiagnosed due to its indolent symptoms, which only manifest at an advanced and potentially incurable stage. Case Report: This case report is that ofa recent case of a GIST of gastric origin. Itdiscusses the case of a 56-year-old, non-smoking male with no comorbiditieswho presented to the emergency department with severe colicky intermittent adnominal pain that had occurred over the past three days, approximately three years ago. On September3, 2019, the patient underwent laparotomy in which a mass and related small bowel segment (the part of the omentum) was removed. Later, the pathology profile revealed a neoplasm of the small bowel-Ileum, Gastrointestinal stromal tumor (GIST) with a high-risk tumor of stage 4 with no recorded nodular involvement and no recorded metastasis pT4 pNxpMx but with clear margins. Moreover, the tumor markers KIT (CD117), CD34, and DOG1 (ANO1) were found to be positive. Ki67 was noted up to 35%. However, S-100 and SMA were found to be negative. On gross examination, the lesion's greatest dimension was 11 cm, and other dimensions were 9x6 cm. The tumor had a spindle-shaped morphology. On the basis of these laboratory findings and pathology profile, the patient's diagnosis was a Gastrointestinal Stromal tumor thatwas managed viasurgery. At that time, the patient was also prescribed Imatinib 400 mg. It has been three years since then, our patient is still alive, and no cancer recurrence has been reported yet. Conclusion: This case report revealed that interventional radiology's early engagement with the surgical procedure was the cornerstone of our patient's effective treatment and should be investigated at different stages of the gastrointestinal tumor.

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Long term survival of patients with gastric cancer treated with adjuvant radio-chemotherapy: proposal of a prognostic index with implication for treatment modification

Cited by 3 publications

References 19 publications

Treatment of Patients With Advanced Cancer Following Chemotherapy and Traditional Medicine - Long Term Follow Up of 75 Cases

Treatment of Patients With Advanced Cancer Following Chemotherapy and Traditional Medicine - Long Term Follow Up of 75 Cases

Clinical prolonged follow up of patients with advanced cancers after chemotherapy with traditional medicine (78 cases)

A Case Report of an Advanced Stage Gastrointestinal Stromal Tumor Successfully Treated by Surgery and Imatinib

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