Long-term survival of patients with idiopathic inflammatory myopathies: anatomy of a single-centre cohort

Abstract

ObjectiveWe aimed to characterise clinical manifestations, disease course, treatment, and mortality of IIM patients.We have also attempted to identify predictors of mortality in IIM. MethodsThis was a retrospective single-centre study including IIM patients fulfilling the Bohan and Peter criteria. Patients were divided in 6 groups: adult-onset polymyositis (APM), adult-onset dermatomyositis (ADM), juvenileonset dermatomyositis, 'overlap' myositis (OM), cancer-associated myositis, and antisynthetase syndrome. Sociodemographic, clinical and immunological features, treatment, and causes of death were recorded. Survival analysis and predictors of mortality was performed using Kaplan-Meier and Cox proportional hazards regression. ResultsA total of 158 patients were included with a mean age at diagnosis of 40.8±15.6 years. Most patients were female (77.2%) and Caucasian (63.9%). The most frequent diagnoses were ADM (35.4%), OM (20.9%) and APM (24.7%), respectively. Most patients (74.1%) were treated with a combination of steroids and one-to-three immunosuppressive drugs.

Pyomyositis Secondary to Localized Cellulitis in a Dermatomyositis Patient: A Case Report and Review of Infectious Complications in Dermatomyositis

“…Deaths No. Deaths (Infection) Mean Age Male% Study IIM GCs/ISD/BT 97 24 7(7.2%) At diagnosis 40.5 25.8% R Marta 2016 2 IIM GCs/ISD/BT 479 114 26(5.4%) At diagnosis 44.0 26.0% R Laura 2017 3 IIM GCs/ISD/BT 467 113 27(5.7%) At diagnosis 41.1 26.0% R Laura 2017 4 IIM GCs/ISD/BT 90 13 4(4.4%) At diagnosis 38.5 28.9% R Taborda 2014 5 IIM GCs/ISD/BT 370 118 26(7.0%) – – R Limaye 2012 6 IIM GCs/ISD 158 46 13(8.2%) At diagnosis 40.8 22.8% R Francisca 2023 7 DM GCs/ISD/BT 100 …”