Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases

Zhai, Junqiu; Wang, Yue; Zhou, Xiangping; Ma, Yan; Guan, Shixia

doi:10.1080/10717544.2020.1815896

Cited by 20 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with natural polymers, the properties and functions of synthetic biodegradable polymers are more predictable (Panchal & Vasava, 2020 ). PLGA, as a synthetic polymer, is one of the most widely used drug delivery carrier (Zeng et al, 2013 ; Cheng et al, 2018 ; Shi et al, 2020 ), which can transport proteins (Xu et al, 2020 ; Zhai et al, 2020 ), peptides (Cai et al, 2019 ; Zhang et al, 2020 ; Jin et al, 2021 ), bacterial or viral DNA (Koerner et al, 2019 ; Lu et al, 2020 ), and various anticancer drugs (Lee et al, 2018 ; Shakeri et al, 2020 ). PLGA is synthesized by random polymerization of lactic acid (LA) and glycolic acid (GA), which has good biocompatibility and biodegradability (Peng et al, 2018 ; Ma et al, 2020 ).…”

Section: Plga As Biodegradable Microsphere Carrier Materialsmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

308

106

View full text Add to dashboard Cite

Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

show abstract

Section: Plga As Biodegradable Microsphere Carrier Materialsmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

308

106

View full text Add to dashboard Cite

show abstract

“…The application of polymeric particles in drug delivery has been rapidly developed in the past several decades [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Particle-based therapeutics offer considerable benefits compared with traditional pharmaceuticals, such as controlling release rates, overcoming biological barriers, delivering hydrophobic drugs, and targeting specific sites [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications

Liu

McEnnis

2022

Polymers

View full text Add to dashboard Cite

Over recent decades, poly(lactic-co-glycolic acid) (PLGA) based nano- and micro- drug delivery vehicles have been rapidly developed since PLGA was approved by the Food and Drug Administration (FDA). Common factors that influence PLGA particle properties have been extensively studied by researchers, such as particle size, polydispersity index (PDI), surface morphology, zeta potential, and drug loading efficiency. These properties have all been found to be key factors for determining the drug release kinetics of the drug delivery particles. For drug delivery applications the drug release behavior is a critical property, and PLGA drug delivery systems are still plagued with the issue of burst release when a large portion of the drug is suddenly released from the particle rather than the controlled release the particles are designed for. Other properties of the particles can play a role in the drug release behavior, such as the glass transition temperature (Tg). The Tg, however, is an underreported property of current PLGA based drug delivery systems. This review summarizes the basic knowledge of the glass transition temperature in PLGA particles, the factors that influence the Tg, the effect of Tg on drug release behavior, and presents the recent awareness of the influence of Tg on drug delivery applications.

show abstract

“…Biodegradable synthetic polymers are increasingly used in supportive therapy drug delivery devices [ 10 ]. As a synthetic polymer, poly (d,l-lactic-co-glycolic acid) (PLGA) could transport proteins [ 11 ], peptides [ 12 ], bacterial or viral DNA [ 13 ], and various anticancer drugs [ 14 ]. PLGA presents excellent biodegradability, biocompatibility, and sustained release [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Activation of PTEN/P13K/AKT Signaling Pathway by miRNA-124-3p-Loaded Nanoparticles to Regulate Oxidative Stress Attenuates Cardiomyocyte Regulation and Myocardial Injury

Cheng

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

As a common cardiovascular disease, acute myocardial infarction seriously affects the health and life of patients. miRNAs play an important role in acute myocardial infarction. Based on miRNA obtained from the previous sequencing, this study investigated whether miRNA (miR)-124-3p-loaded nanoparticles (NPs) affect the phenotype of the acute myocardial infarction (AMI) rat. Nano-miR-124-3p decreased the myocardial infarction area, improved the myocardial tissue structure, and increased the degree of fibrosis. Nano-miR-124-3p decreased apoptosis and the expression of cleaved caspase 3, indicating its role in protecting and repairing the myocardium. To further verify the action mechanism of miRNA, a potential target gene of miR-124-3p, PTEN was identified by STARBASE and further confirmed using double luciferase assays. Following cotransfection of nano-miR-124-3p and PTEN, the areas of tissue structure damage, myocardial infarction, and fibrosis were substantially elevated. The expression of cleaved caspase 3 and the apoptosis rate in the nano-miR-124-3p and PTEN cotransfection group was also significantly increased. Bioinformatics analysis revealed that miRNA-124-3 may regulate oxidative stress injury by targeting PTEN. Taken together, miR-124-3p could protect and repair myocardial tissues through targeting PTEN.

show abstract

Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases

Abstract: Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases,

Cited by 20 publications

References 37 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Glass Transition Temperature of PLGA Particles and the Influence on Drug Delivery Applications

Activation of PTEN/P13K/AKT Signaling Pathway by miRNA-124-3p-Loaded Nanoparticles to Regulate Oxidative Stress Attenuates Cardiomyocyte Regulation and Myocardial Injury

Contact Info

Product

Resources

About