Long-term Symptoms after External Beam Radiation Therapy for Prostate Cancer with Three or Four Fields

al-Abany, Massoud; Helgason, Ásgeir R.; Cronqvist, Anna-Karin Ågren; Svensson, Christer; Wersäll, Peter; Steineck, Gunnar

doi:10.1080/028418602320807801

Cited by 8 publications

(11 citation statements)

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“…A cross sectional study of 989 prostate cancer patients treated with RT showed that defecation urgency was the most common symptom among survivors after 2-14 years' follow-up, followed by faecal leakage and loose stools (16). Similar results have been presented in patients treated with pelvic irradiation, both men and women, where defecation urgency and faecal leakage has been identified as the most disturbing of all radiation-induced symptoms (17)(18)(19)(20)(21). In the neoadjuvant study (12), differences between the groups at the three months' assessment, before the start of RT, were found for 'overall quality of life', 'fatigue' and 'sexual interest', all in favour of monotherapy.…”

Section: Discussionmentioning

confidence: 61%

Effect on prostate volume following neoadjuvant treatment with an androgen receptor inhibitor monotherapy versus castration plus an androgen receptor inhibitor in prostate cancer patients intended for curative radiation therapy: A randomised study

et al. 2017

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Abstract. To avoid pubic arch interference, prostate cancer patients are treated with neoadjuvant androgen deprivation therapy (ADT) to achieve prostate volume (PV) reduction prior to radiation treatment. The aim of the present randomised study was to compare the effects on PV of two regimens of ADT, an androgen receptor inhibitor monotherapy vs. castration plus an androgen receptor inhibitor. Consecutive patients with non-metastatic prostate cancer were included in a randomised neoadjuvant study, comparing an androgen receptor inhibitor monotherapy vs. castration plus an androgen receptor inhibitor. PV was assessed prior to the start of endocrine neoadjuvant treatment and prior to the start of radiation therapy (RT). PV assessment was performed by transrectal ultrasound. A total of 110 patients were included. Final sample constituted 88 (80%) patients due to lack of PV information. Castration plus an androgen receptor inhibitor was more effective in PV reduction compared with an androgen receptor inhibitor alone (P<0.001). Planning target volume decreased in the combination arm. There was no significant difference in clinical or demographic or length of neoadjuvant hormonal treatment between the groups. Overall, a significantly larger PV reduction was achieved by castration plus androgen receptor inhibitor, as compared with androgen receptor inhibitor monotherapy. The PV reduction, however, appeared not to translate into better health associated quality of life during the subsequently given curative intended combined EBRT and HDR-brachytherapy. Potential differences between these two treatments regarding anti-tumor effects on micro metastatic disease and radiation potentiating effect remains to be addressed in future prospective trials.

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Section: Discussionmentioning

confidence: 61%

Effect on prostate volume following neoadjuvant treatment with an androgen receptor inhibitor monotherapy versus castration plus an androgen receptor inhibitor in prostate cancer patients intended for curative radiation therapy: A randomised study

et al. 2017

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“…CRT for example, limits radiation damage to surrounding tissues compared to conventional ERT. 95,103 Brachytherapy (BRT) with Iodine-125 (I125) or Palladium-103 (Pd103) radiation appears to be about as effective as ERT but further minimizes radiation damage to surrounding tissue.…”

Section: Literature Reviewmentioning

confidence: 99%

Estimating the risk of long-term erectile, urinary and bowel symptoms resulting from prostate cancer treatment

Bhatnagar

Stewart

Huynh

et al. 2006

Prostate Cancer Prostatic Dis

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Reports on long-term complications resulting from treatment for localized prostate cancer are very inconsistent. In order to estimate the risks of long-term erectile dysfunction, urine symptoms and bowel symptoms following prostatectomy (RP), external conventional or conformal beam radiation (ERT or CRT) and brachytherapy (BRT), 98 papers from the PubMed and Cochrane Clinical Trial databases were selected, reviewed and critically evaluated. The majority of papers were institutionbased retrospective and prospective follow-up studies; only two of these studies measured the risk of developing more than one treatment complication. Due to differences in study designs and populations, it is difficult to directly compare studies and not meaningful to calculate summary estimates. In addition to focusing on randomized clinical trials and well-designed population based studies, future research should adopt standardized methodologies and should measure the risk of developing more than one treatment complication.

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“…Following curative intent radiotherapy for other pelvic malignancies, including bladder, prostate and cervical cancer, long-term anorectal symptoms were among the most important sources of distress [17][18][19][20]. Long-term faecal incontinence caused the highest level of distress in 10-14% and faecal urgency in 14% of patients [17,18].…”

Section: Introductionmentioning

confidence: 99%

Long‐term anorectal, urinary and sexual dysfunction causing distress after radiotherapy for anal cancer: a Danish multicentre cross‐sectional questionnaire study

et al. 2015

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Long-term Symptoms after External Beam Radiation Therapy for Prostate Cancer with Three or Four Fields

Cited by 8 publications

References 0 publications

Effect on prostate volume following neoadjuvant treatment with an androgen receptor inhibitor monotherapy versus castration plus an androgen receptor inhibitor in prostate cancer patients intended for curative radiation therapy: A randomised study

Effect on prostate volume following neoadjuvant treatment with an androgen receptor inhibitor monotherapy versus castration plus an androgen receptor inhibitor in prostate cancer patients intended for curative radiation therapy: A randomised study

Estimating the risk of long-term erectile, urinary and bowel symptoms resulting from prostate cancer treatment

Long‐term anorectal, urinary and sexual dysfunction causing distress after radiotherapy for anal cancer: a Danish multicentre cross‐sectional questionnaire study

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