Long-term symptoms after radiotherapy of supraclavicular lymph nodes in breast cancer patients

Lundstedt, Dan; Gustafsson, Magnus; Steineck, Gunnar; Alsadius, David; Sundberg, Agnetha; Wilderäng, Ulrica; Holmberg, Erik; Johansson, Karl-Axel; Karlsson, Per

doi:10.1016/j.radonc.2011.12.017

Cited by 40 publications

(21 citation statements)

References 21 publications

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“…Four studies [17], [28]–[30] focused only on patients that underwent ALND. One systematic review [1] and one cross-sectional study [27] focused on the adverse effects of radiotherapy. The adverse effects of aromatase inhibitors focused on musculoskeletal pain.…”

Section: Resultsmentioning

confidence: 99%

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Treatment Related Impairments in Arm and Shoulder in Patients with Breast Cancer: A Systematic Review

et al. 2014

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BackgroundBreast cancer is the most common type of cancer in women in the developed world. As a result of breast cancer treatment, many patients suffer from serious complaints in their arm and shoulder, leading to limitations in activities of daily living and participation. In this systematic literature review we present an overview of the adverse effects of the integrated breast cancer treatment related to impairment in functions and structures in the upper extremity and upper body and limitations in daily activities. Patients at highest risk were defined.Methods and FindingsWe conducted a systematic literature search using the databases of PubMed, Embase, CINAHL and Cochrane from 2000 to October 2012, according to the PRISMA guidelines. Included were studies with patients with stage I–III breast cancer, treated with surgery and additional treatments (radiotherapy, chemotherapy and hormonal therapy). The following health outcomes were extracted: reduced joint mobility, reduced muscle strength, pain, lymphedema and limitations in daily activities. Outcomes were divided in within the first 12 months and >12 months post-operatively. Patients treated with ALND are at the highest risk of developing impairments of the arm and shoulder. Reduced ROM and muscle strength, pain, lymphedema and decreased degree of activities in daily living were reported most frequently in relation to ALND. Lumpectomy was related to a decline in the level of activities of daily living. Radiotherapy and hormonal therapy were the main risk factors for pain.ConclusionsPatients treated with ALND require special attention to detect and consequently address impairments in the arm and shoulder. Patients with pain should be monitored carefully, because pain limits the degree of daily activities. Future research has to describe a complete overview of the medical treatment and analyze outcome in relation to the treatment. Utilization of uniform validated measurement instruments has to be encouraged.

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Section: Resultsmentioning

confidence: 99%

“…[4], [16]–[21], [23], [26]–[30], [32], [34], [39], [42]–[45] Eight studies reported subjective data based on a lymphedema questionnaire, [16], [23], [26], [28] CTCAE, [21], [27] telephone interview, [23], [26] or measured only 2 or 3 points of the arm. [18], [19].…”

Section: Resultsmentioning

confidence: 99%

Treatment Related Impairments in Arm and Shoulder in Patients with Breast Cancer: A Systematic Review

et al. 2014

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“…Fibrosis and lymphedema are more frequent during SCF irradiation and tumor bed boost. The upper limbs are less impaired when RT excludes the axilla 6 , 9 , 21 - 22 .…”

Section: Discussionmentioning

confidence: 99%

Supervised physical therapy in women treated with radiotherapy for breast cancer

Leal

Oliveira

Carrara

2016

Rev. Latino-Am. Enfermagem

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Objective: to evaluate the effect of physical therapy on the range of motion of the shoulders and perimetry of the upper limbs in women treated with radiotherapy for breast cancer.Methods: a total of 35 participants were randomized into two groups, with 18 in the control group (CG) and 17 in the study group (SG). Both of the groups underwent three evaluations to assess the range of motion of the shoulders and perimetry of the upper limbs, and the study group underwent supervised physical therapy for the upper limbs. Results: the CG had deficits in external rotation in evaluations 1, 2, and 3, whereas the SG had deficits in flexion, abduction, and external rotation in evaluation 1. The deficit in abduction was recovered in evaluation 2, whereas the deficits in all movements were recovered in evaluation 3. No significant differences in perimetry were observed between the groups. Conclusion: the applied supervised physical therapy was effective in recovering the deficit in abduction after radiotherapy, and the deficits in flexion and external rotation were recovered within two months after the end of radiotherapy. Registration number of the clinical trial: NCT02198118.

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“…16,17 Increasing receipt of BCS without radiation over time may be driven by concerns over long-term effects of chest irradiation in young women. 39,40 On the other hand, it is also likely that radiation receipt is underascertained by the registry, particularly with increasing use of neoadjuvant therapies that may result in underreport of adjuvant radiation occurring later in the treatment process. 41 Compared to BCS with radiation, mastectomy receipt increased in the final years of the study period.…”

Section: Changes In Treatment Receipt Over Timementioning

confidence: 99%

A Population-Based Observational Study of First-Course Treatment and Survival for Adolescent and Young Adult Females with Breast Cancer

DeRouen

Gomez

Press

et al. 2013

Journal of Adolescent and Young Adult Oncology

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Purpose: Young age at breast cancer diagnosis is associated with poor survival. However, little is known about factors associated with first-course treatment receipt or survival among adolescent and young adult (AYA) females aged 15-39 years. Methods: Data regarding 19,906 eligible AYA breast cancers diagnosed in California during 1992-2009 were obtained from the population-based California Cancer Registry. Multivariable logistic regression was used to evaluate clinical and sociodemographic differences in treatment receipt. Multivariable Cox proportional hazards regression was used to examine differences in survival by initial treatment, and by patient and tumor characteristics. Results: Black and Hispanic AYAs diagnosed with in situ or stages I-III breast cancer were more likely than White AYAs to receive breast-conserving surgery (BCS) without radiation; Asian and Hispanic AYAs were more likely than Whites to receive mastectomy. Women in lower socioeconomic status (SES) neighborhoods were more likely to omit radiation after BCS, more likely to receive mastectomy, and less likely to receive chemotherapy, compared to those in higher SES neighborhoods. Among patients with invasive disease, survival improved an average of 5% per year during 1992-2009. AYAs who received BCS with radiation experienced better survival than other surgery/ radiation options. Black AYAs had poorer survival than Whites. AYAs who resided in higher SES neighborhoods had better survival. Conclusions: Treatment receipt among AYAs with breast cancer varied by race/ethnicity and neighborhood SES. Poor survival for Black AYAs and AYAs living in low SES neighborhoods in models adjusted for treatment receipt suggests that factors other than treatment may also be important to disease outcome.

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Long-term symptoms after radiotherapy of supraclavicular lymph nodes in breast cancer patients

Cited by 40 publications

References 21 publications

Treatment Related Impairments in Arm and Shoulder in Patients with Breast Cancer: A Systematic Review

Treatment Related Impairments in Arm and Shoulder in Patients with Breast Cancer: A Systematic Review

Supervised physical therapy in women treated with radiotherapy for breast cancer

A Population-Based Observational Study of First-Course Treatment and Survival for Adolescent and Young Adult Females with Breast Cancer

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