Long-term therapeutic efficacy of lipoprotein apheresis on circulating oxidative stress parameters – A comparison of two different apheresis techniques

Kopprasch, Steffi; Bornstein, Stefan R.; Bergmann, S.; Graessler, Juergen; Julius, Ulrich

doi:10.1016/j.atherosclerosissup.2015.02.016

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…We found significant decrease in oxidized LDL levels indicating the beneficial effect of apheresis on oxidative processes, which have also been reported previously . Oxidized LDL levels after treatment were even lower than the values of controls.…”

Section: Resultssupporting

confidence: 90%

“…We found significant decrease in oxidized LDL levels indicating the beneficial effect of apheresis on oxidative processes, which have also been reported previously. [26][27][28] Oxidized LDL levels after treatment were even lower than the values of controls. The striking reduction in oxidized LDL but elevation of both αand γ-tocopherol/cholesterol levels after apheresis suggest that oxidized LDL is not only low in afamin but also contains low αand γ-tocopherol in FH.…”

Section: Resultsmentioning

confidence: 78%

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Changes in serum afamin and vitamin E levels after selective LDL apheresis

Varga

Lőrincz

Szentpéteri

et al. 2018

J of Clinical Apheresis

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LDL apheresis moderately decreases the circulating levels of afamin parallel to lowering HDL-C and ApoA1 levels. Tocopherol levels decreases markedly compared to afamin levels, however, beneficial changes in vitamin E/cholesterol ratios, oxidized LDL levels and HDL subfraction distribution were detected. These additional effects of LDL apheresis may result in further cardiovascular risk reduction in FH patients.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 78%

Changes in serum afamin and vitamin E levels after selective LDL apheresis

Varga

Lőrincz

Szentpéteri

et al. 2018

J of Clinical Apheresis

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“…In addition, LA treatment is recognized as safe and can improve the prognosis of patients with progressive CVD . Besides effectively lowering plasma lipid levels, investigations of a single LA treatment on OS parameters, and on the relationship between blood lipids and these parameters were rare and remained conflicts …”

Section: Introductionmentioning

confidence: 99%

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Wen

Dong

et al. 2019

Clinical Laboratory Analysis

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Background and aims: Familial hypercholesterolemia (FH) characterized by severe high blood cholesterol levels usually presents an imbalance of systemic oxidative stress(OS).Lipoproteinapheresis(LA),whichisthemosteffectivetherapytoreduce cholesterollevels,remainsunclearinalteringOSandscarceinChinesepatientstudies. OurstudyaimstoassesstheimpactofLAonOSstatusinChinesepatientswithFH.Methods: About31patients(22males,age:12-69years)withFHandreceivingLA treatment were consecutive enrolled. Free oxygen radicals test (FORT) and free oxygen radicals defense (FORD) values were determined using the free oxygen radical monitor and kit immediately before and after LA, while blood samples were collected to measure plasma lipid levels and hs-CRP by conventional methods. Data were analyzed by paired ttestorranksumtestandSpearman-rhocorrelationanalysis.Results: Besides plasma lipid levels, the OS status showed that FORTs were significantly decreased and FORD values significantly enhanced immediately after LA treatment compared with before (both P < .01). In addition, the correlation analysis showed that the removal rates (△%) of TC were positively related to the increased rates (△%) of FORD value (ρ = 0.513, P = .003); LDL-C to FORD (ρ = 0.39, P = .03); Lp(a) to FORD (ρ=0.473,P=.007);andnon-HDL-CtoFORD(ρ = 0.46, P = .009). However,nosignificantdifferenceinhsCRPwasfound.Conclusions: The present study indicated, besides effectively lowering plasma lipid levels,LAcouldsignificantlyimproveOSstatusinChinesepatientswithFH. K E Y W O R D S familial hypercholesterolemia, lipoprotein apheresis, oxidative stressThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…It should be noted a number of important pleiotropic and non-lipid, anti-inflammatory and rheological effects during the selective lipid apheresis [37,[40][41][42] . Hibino et al [43] (2009) demonstrated anti-inflammatory and homeostasis-correcting effects of cascade rheofiltration.…”

Section: Discussionmentioning

confidence: 99%

The use of lipoprotein apheresis for the treatment of high-risk patients with elevated lipoprotein(a) and hypercholesterolemia

Yaroustovsky¹,

Abramyan²,

Rogalskaya³

et al. 2019

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Aim: To assess the safety and efficiency of H.E.L.P.-apheresis and cascade lipid-filtration in the treatment of severe lipid disorders in high-risk patients. Methods: From 2016 to 2018 we observed 6 patients hyperLDLemia and high Lp(a)emia (> 60 mg/dL). The first group with H.E.L.P.-apheresis (n = 74 sessions) included 3 patients who underwent revascularization (coronary, femoral arteries). In the second group with cascade lipid-filtration (n = 92 sessions)-one patients underwent revascularization, two patients received drug therapy. Despite the lipid-lowering conventional therapy, no targeted low density lipoprotein (LDL) was obtained. Results: The patients of the 1st group had threefold decrease of LDL, in patients of the 2nd group LDL decreased by 68%. At the same time, in both groups, we noted a decrease in Lp(a) after the procedure by 65%-68%. Despite a decrease in high density lipoprotein (by 22%-29%) after lipid apheresis procedures, there was a positive trend in apoB100/apoA index (a decrease of 33% after HELP-apheresis procedures and 60% after cascade lipid-filtration) and a decrease in atherogenic index (38% and 53%, respectively). The changes in hematological and haemostatic parameters remained within physiological intervals. Conclusion: We noticed the successful application of lipid apheresis in patients with multifocal atherosclerosis and its complications.

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Long-term therapeutic efficacy of lipoprotein apheresis on circulating oxidative stress parameters – A comparison of two different apheresis techniques

Cited by 13 publications

References 18 publications

Changes in serum afamin and vitamin E levels after selective LDL apheresis

Changes in serum afamin and vitamin E levels after selective LDL apheresis

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

The use of lipoprotein apheresis for the treatment of high-risk patients with elevated lipoprotein(a) and hypercholesterolemia

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