2003
DOI: 10.2165/00151642-200310020-00004
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Long-Term Tolerability and Efficacy of the Fixed Combination of Manidipine and Delapril in Patients with Essential Hypertension

Abstract: Aim:The aim of this study was to assess the long-term tolerability and efficacy of a fixed combination of manidipine 10mg and delapril 30mg (M+D) as an antihypertensive treatment in patients with mild to moderate hypertension. Study design: This was a multicentre open study, with a two-week placebo run-in period, followed by a 50-week active treatment period. Three hundred and nine patients with a mean age of 56.4 years and a sitting (Si) diastolic blood pressure (DBP) of ≥95mm Hg and ≤110mm Hg were enrolled. … Show more

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Cited by 6 publications
(1 citation statement)
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“…Cough is thought to be a class effect, but there is considerable variation in estimates of the occurrence of coughing due to ACE inhibitors in the various systematic reviews and meta-analyses, probably due to the method used for its investigation. 24 , 25 , 34 , 41 – 55 These differences reflect study design (postmarketing or general population studies versus randomized controlled studies), method of ascertaining the presence of cough (spontaneous reports, systematic inquiry, patient self-reporting), method of measuring occurrence of the phenomenon, and the size of the study. 25 , 56 , 57 The complex pathophysiology of the phenomenon may also explain why this adverse effect is variable in occurrence (3%–35% in the various studies).…”
Section: Ace Inhibition and Coughmentioning
confidence: 99%
“…Cough is thought to be a class effect, but there is considerable variation in estimates of the occurrence of coughing due to ACE inhibitors in the various systematic reviews and meta-analyses, probably due to the method used for its investigation. 24 , 25 , 34 , 41 – 55 These differences reflect study design (postmarketing or general population studies versus randomized controlled studies), method of ascertaining the presence of cough (spontaneous reports, systematic inquiry, patient self-reporting), method of measuring occurrence of the phenomenon, and the size of the study. 25 , 56 , 57 The complex pathophysiology of the phenomenon may also explain why this adverse effect is variable in occurrence (3%–35% in the various studies).…”
Section: Ace Inhibition and Coughmentioning
confidence: 99%