Long-term total sleep deprivation reduces thalamic gray matter volume in healthy men

Liu, Chunlei; Kong, Xiangzhen; Liu, Xueyong; Zhou, Renlai; Wu, Bin

doi:10.1097/wnr.0000000000000091

Cited by 45 publications

(39 citation statements)

References 19 publications

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“…Sleep deprivation has been proven to affect cognitive functions [20,2] and subsequently memory consolidation and recall [35,3,38]. Moreover, such deprivation may cause serious health problems [12,6,27]. Simultaneously, the pace of life is constantly accelerating [40].…”

Section: Withdrawal Reasons Analysismentioning

confidence: 99%

Building engagement for MOOC students

Nawrot

Doucet

2014

Proceedings of the 23rd International Conference on World Wide Web

114

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The main objectives of massive open online courses (MOOC) are to foster knowledge through free high quality learning materials procurement; to create new knowledge through diverse users' interactions with the providing platform; and to empower research on learning. However, MOOC providers are also businesses (either profit or not-for-profit). They are still in the early stages of their development, but sooner or later, in order to secure their existence and assure their longterm growth, they will have to adapt a business model and monetize the services they provide. Nevertheless, despite their popularity MOOCs are characterized by a very high drop-out rate (about 90% [33,22,26]), which may turn out to be a problem regardless of the adapted business model. Hence, MOOC providers can either assume the scale benefits to be sufficiently high to ignore the problem of low MOOC completion rate or tackle this problem.In this paper we explore the problem of the high dropout rate in massive open online courses. First, we identify its main cause by conducting an online survey, namely bad time organization. Secondly, we provide suggestions to reduce the rate. Specifically, we argue that MOOC platforms should not only provide their users with high quality educational materials and interaction facilities. But they should also support and assist the users in their quest for knowledge. Thus, MOOC platforms should provide tools helping them optimize their time usage and subsequently develop metacognitive skills indispensable in proper time management of learning processes.

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Section: Withdrawal Reasons Analysismentioning

confidence: 99%

Building engagement for MOOC students

Nawrot

Doucet

2014

Proceedings of the 23rd International Conference on World Wide Web

114

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“…A recent study in humans examined hippocampal and thalamic gray matter volume by MRI before and after 72 h total sleep deprivation (98). The group found reduced volume in the thalamus but not in the hippocampus.…”

Section: Effects Of Sleep Loss On Hippocampal Function and Connectivitymentioning

confidence: 99%

Neural Consequences of Chronic Short Sleep: Reversible or Lasting?

Zhao

Veasey

2017

Front. Neurol.

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Approximately one-third of adolescents and adults in developed countries regularly experience insufficient sleep across the school and/or work week interspersed with weekend catch up sleep. This common practice of weekend recovery sleep reduces subjective sleepiness, yet recent studies demonstrate that one weekend of recovery sleep may not be sufficient in all persons to fully reverse all neurobehavioral impairments observed with chronic sleep loss, particularly vigilance. Moreover, recent studies in animal models demonstrate persistent injury to and loss of specific neuron types in response to chronic short sleep (CSS) with lasting effects on sleep/wake patterns. Here, we provide a comprehensive review of the effects of chronic sleep disruption on neurobehavioral performance and injury to neurons, astrocytes, microglia, and oligodendrocytes and discuss what is known and what is not yet established for reversibility of neural injury. Recent neurobehavioral findings in humans are integrated with animal model research examining long-term consequences of sleep loss on neurobehavioral performance, brain development, neurogenesis, neurodegeneration, and connectivity. While it is now clear that recovery of vigilance following short sleep requires longer than one weekend, less is known of the impact of CSS on cognitive function, mood, and brain health long term. From work performed in animal models, CSS in the young adult and short-term sleep loss in critical developmental windows can have lasting detrimental effects on neurobehavioral performance.

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“…5,6 The existence of structural and metabolic alterations in the thalamus or brain circuits involving the thalamus among right-handed patients with insomnia or sleepdeprived individuals has been replicated in neuro imaging studies. [7][8][9] Reduced bilateral thalamic grey-matter volume after sleep deprivation 7 and atrophic changes in the thalamus in patients with insomnia 8 have been shown. Patients with insomnia had decreased thalamic metabolic differences between non-rapid eye movement (NREM) sleep at night and wakefulness in the morning compared with controls.…”

Section: Introductionmentioning

confidence: 97%

Low white-matter integrity between the left thalamus and inferior frontal gyrus in patients with insomnia disorder

Kang

Joo

Son

et al. 2018

jpn

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Background: Previous studies have reported functional and structural abnormalities in the thalamus and the pars triangularis of the infer ior frontal gyrus in patients with insomnia disorder. However, no studies have been conducted on the white-matter tracts between these 2 brain regions. We aimed to compare the white-matter integrity and structure of the left thalamus-pars triangularis tracts between patients with insomnia and controls, and to characterize the relationship between white-matter integrity and clinical features in patients with insomnia. Methods: In total, 22 participants with insomnia disorder and 27 controls underwent overnight polysomnography and brain magnetic resonance imaging, and then completed self-report clinical questionnaires and neurocognitive tests for spatial planning. Structural and diffusion measures such as fractional anisotropy, axial diffusivity, radial diffusivity and trace were analyzed in group comparison and correlation analyses. Results: The insomnia group showed significantly lower fractional anisotropy (F = 8.647, p = 0.02) and axial diffusivity (F = 5.895, p = 0.038) in the left thalamus-pars triangularis tracts than controls. In patients with insomnia, fractional anisotropy in the tracts was correlated with the results of the Stockings of Cambridge test (r = 0.451, p = 0.034), and radial diffusivity was correlated with Epworth Sleepiness Scale score (r = 0.437, p = 0.042). Limitations: Limitations included analyses of limited brain regions and the cross-sectional design. Conclusion: The insomnia group showed decreased integrity in the left thalamus-pars triangularis tracts, and integrity was correlated with cognition and daytime sleepiness. These results may imply that insomnia is characterized by disintegration of the white-matter tract between the left thalamus and inferior frontal gyrus.

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Long-term total sleep deprivation reduces thalamic gray matter volume in healthy men

Cited by 45 publications

References 19 publications

Building engagement for MOOC students

Building engagement for MOOC students

Neural Consequences of Chronic Short Sleep: Reversible or Lasting?

Low white-matter integrity between the left thalamus and inferior frontal gyrus in patients with insomnia disorder

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