Long-term toxicity study on genetically modified corn with <i>cry1Ac</i>
 gene in a Wuzhishan miniature pig model

Chen, Liang; Sun, Zhe; Liu, Quanwei; Zhong, Ruqing; Tan, Shanzhong; Yang, Xiaoguang; Zhang, Hongfu

doi:10.1002/jsfa.7624

Cited by 9 publications

(11 citation statements)

References 25 publications

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“…A long-term (196 days) toxicity study on Bt corn (1.32 mg/kg BW) in a WZSP model found the same results for males. 31 In addition, these differences were not simultaneous in both sexes and were within the normal reference intervals for Wuzhishan pigs. 42 The liver enzyme, AST, was lower in females fed Bt rice than in the control group, paralleling the study of Buzoianu et al 43 ALP values were higher in the Bt group than the Minghui86 group in male pigs but not females.…”

Section: ■ Discussionmentioning

confidence: 75%

“…39 Liang Chen et al also reported that hematological parameters did not differ in Wuzhishan miniature pigs that were fed Bt corn expressing the Cry1Ac protein. 31 Sporadic significant differences in serum biochemical values between the Bt and Minghui86 groups were noted. Increased liver size and enzyme levels are indictors of liver dysfunction.…”

Section: ■ Discussionmentioning

confidence: 96%

“…This agrees with the observation of a long-term (196 days) toxicity study on Bt corn (1.32 mg/kg BW) in a WZSP model, which showed that the cry1Ac gene had no effect on the growth, immune response, or health indicators at any growth stage. 31 In addition, the birth/ weaning and slaughter weights also showed that the Bt rice did not influence growth performance. Similar to our findings, Walsh et al reported that there were no differences in feed consumption, average daily gain, and feed conversion efficiency between pigs fed with Bt MON810 maize and the control diet.…”

Section: ■ Discussionmentioning

confidence: 99%

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Effects of 60-Week Feeding Diet Containing Bt Rice Expressing the Cry1Ab Protein on the Offspring of Inbred Wuzhishan Pigs Fed the Same Diet

Liu

Yang

et al. 2017

J. Agric. Food Chem.

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We evaluated the chronic effects of Bt rice carrying the Cry1Ab protein (1.64 mg/kg) on offspring of highly inbred WZSP, fed with Bt rice for 360 days, in a 60-week feeding study. The WZSP offspring (n = 27) were assigned to two groups (Minghui86 group, female n = 6, male n = 5; Bt group, female n = 11, male n = 5). The average obtained Cry1Ab protein dosage for female and male pigs was 1.003 and 1.234 mg/kg body weight after 10 weeks of feeding, respectively. The experimental feed in the study was nutritionally matched in both groups. The average daily gain and feed conversion ratio of the females in week 3 and males from weeks 1 to 10 were different between the Bt and Minghui86 groups (P < 0.05), and the body weight of the male pigs in week 2 was greater in the Minghui86 group than that of the Bt group (P < 0.05). No other differences were observed, and there were no significant differences in the serum sex steroid level, hematology parameters, relative organ weights, or histopathology. Although differences in some serum chemistry parameters (alanine aminotransferase of female pigs and alkaline phosphatase of male pigs) were observed, they were not considered treatment-related. On the basis of these results, long-term intake of transgenic rice carrying Cry1Ab protein exerts no unintended adverse effects on WZSP offspring.

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Section: ■ Discussionmentioning

confidence: 75%

Section: ■ Discussionmentioning

confidence: 96%

Section: ■ Discussionmentioning

confidence: 99%

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Effects of 60-Week Feeding Diet Containing Bt Rice Expressing the Cry1Ab Protein on the Offspring of Inbred Wuzhishan Pigs Fed the Same Diet

Liu

Yang

et al. 2017

J. Agric. Food Chem.

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“…So, independent animal testing have recently confirmed the absence of toxicity of MON 810 GM maize in subchronic and chronic toxicity studies (Petrick at al., 2019). During long-term feeding of GM maize to pigs, their live weight, feed conversion and viability were minimally different from the control indicators (Chen et al, 2016). Scholtz et al (2010) found no deterioration of the immune system in quail when fed on genetically modified maize.…”

Section: Introductionmentioning

confidence: 87%

Effect of GM maize on metabolism and performance of chicken

Gaviley

Pankova

Katerynych

2021

Acta fytotechn zootechn

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Licensed under a Creative Commons Attribution 4.0 International License Genetically modified (GM) maize and conventional maize were tested experimentally to determine their effect on chicken serum biochemical parameters and metabolism. A total of 600 one day old parent stock chickens of breed White Plymouth Rock were divided into 2 experimental groups: K -diet based on traditional maize (control); D -a diet based on GM maize (experimental). During the experimental period (17 weeks), population vibility and feed consumption were monitored daily. At the age of 4, 8 and 17 weeks all birds were individually weighed. Blood samples for biochemical analyses were collected from chickens at 4 weeks and 12 weeks of age (n = 6). Analytical studies did not show significant changes in biochemical serum parameters in group D chickens. A significant difference between the groups of chickens receiving GM and traditional maize was found only by the content of lipids after 4 weeks (P <0.05) and cholesterol after 12 weeks of the experiment (P <0.05). Also noted increasing level of circulating immune complexes in serum of chickens that consumed feed from GM maize relative control at 32.2% (P <0.05) after 4 weeks of the experiment. However, the studied indicators of metabolism and immune response in birds were within the physiological range. Certain fluctuations in the parameters during the experiment were observed in both groups, which indicates that there is no connection between this fact and the feeding factor. In addition, optimal results were obtained in terms of feed conversion and body weight of poultry, regardless of the feeding ration. The body weight of chickens at the age of 17 weeks in both groups was in the range of 1,862.4-1,895.6 g, feed consumption per 1 kg of body weight gain was 3.65-3.76 kg, the livestock viability -96.6-97.3%. The results of the study do not indicate any danger to the metabolism and health of the bird due to the use of genetically modified feed, as no statistically significant differences within the studied parameters were observed. The noted certain small deviations fell within the limits of normal variations of the considered indicators and, thus, had no biological or toxicological value.

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“…Many kinds of research were conducted to evaluate the safety of GM feeding in pigs and rabbits either by giving Bt rice (Liu et al, 2018a, Liu et al, 2018b, Liu et al, 2017 or Bt maize (Chen et al, 2016, Yalçin et al, 2018 presented in Table 2. Chen et al, (2016) conducted a study to investigate the chronic effect of transgenic maize comprise of Cry1Ab protein (1.64 mg/kg) to evaluate the growth performance, immune response and health of Wuzhishan pig after 196-day GM maize feeding. Longterm feeding Bt corn results had no adverse effects of GM maize on pigs.…”

Section: Effects Of Feeding With Gm Crops On Pigs and Rabbitsmentioning

confidence: 99%

Effects of Feeding Genetically Modified Crops to Domestic Animals: A Review

Akram

Yaman

Jalal

et al. 2019

Turkish JAF Sci.Tech.

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Genetically modified (GM) crops are being planted at large scale worldwide. In most of the countries, GM crops are processed into livestock feed. The land is used for cultivation of GM plants has been increased in recent years; in 2012 GM plants were grown on over 170 million hectares in 28 countries by 17.3 million farmers and extended to 185.1 million hectors in 2016 worldwide. GM plants have been used as feed for animals and the number of studies has proved their safety for animal and public health. This paper reviews the possible effects of GM crops on livestock, poultry, and aquatic animals by reviewing different type of studies, in which parameters such as performance, reproductive and health assessment were investigated. The most of peer-reviewed papers evaluating the effects of feeding animals with transgenic crops were based on GM plants with improved agronomic traits i.e. herbicide-tolerant plants and pets-tolerant plants; however, in some cases GM plants with boosted nutritional properties assessed. In most experiments, either Bt (Bacillus thuringiensis) maize, Roundup Ready (RR) soybean or both fed to animals. Measurable differences in various parameters were mostly observed in Bt maize and soybean fed separately or simultaneously to animals. In this review, scientific studies showing the effects of the use of GM products in the nutrition of domestic animals on performance, health and reproductive parameters are investigated.

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Long-term toxicity study on genetically modified corn with cry1Ac gene in a Wuzhishan miniature pig model

Abstract: Long-term feeding Bt corn carrying cry1Ac genes to Wuzhishan miniature pigs did not indicate adverse effects on the growth, immune response and health indicators at any stages of growth. © 2016 Society of Chemical Industry.

Cited by 9 publications

References 25 publications

Effects of 60-Week Feeding Diet Containing Bt Rice Expressing the Cry1Ab Protein on the Offspring of Inbred Wuzhishan Pigs Fed the Same Diet

Effects of 60-Week Feeding Diet Containing Bt Rice Expressing the Cry1Ab Protein on the Offspring of Inbred Wuzhishan Pigs Fed the Same Diet

Effect of GM maize on metabolism and performance of chicken

Effects of Feeding Genetically Modified Crops to Domestic Animals: A Review

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