Long-term tracing and staining of carbon nanoparticles for axillary lymph nodes in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy

Li, Jianyi; Song, Jia; Wang, Yitong; Zhang, Yang; Kong, Linna; Cao, Yanan; Liu, Yushi; Zhang, Yan; Chen, Bin

doi:10.1016/j.asjsur.2021.03.020

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Nanocarbon has good lymphatic tropism and its local diffusion and absorption rates are slower; thus, it remains visible to the naked eye 6 months after labeling. Moreover, compared with traditional dyes, it does not easily affect the surgical field of vision via local halo staining (11,25). Furthermore, the diameter of carbon nanoparticles is too large to enter the blood circulation system, so there is little toxicity and few side effects (26).…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-assisted carbon nanoparticle labeling of neoadjuvant chemotherapy for breast-conserving surgery in breast cancer

Lin¹,

Liu²,

Wang³

et al. 2023

Quant Imaging Med Surg

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Background: Neoadjuvant chemotherapy has gradually become an important means of breast cancer treatment; however, tumor regression following chemotherapy remains a concern. This study was conducted to investigate the effect of ultrasound-assisted carbon nanoparticle labeling in neoadjuvant chemotherapy for breast-conserving surgery in breast cancer.Methods: This was a prospective clinical trial study (clinical registration number: ChiCTR-OOC-15006844). Sixty-eight breast cancer patients confirmed by biopsy between July 2015 and January 2017 were randomly selected from the clinical data. Of these, 32 patients were screened for neoadjuvant chemotherapy, forming a consecutive, random series. An ultrasound-guided carbon nanotube was used to mark the original tumor, and sentinel lymph node biopsies were performed. After 4-6 cycles of standard neoadjuvant chemotherapy, 26 patients were selected for breast-conserving surgery. The feasibility and validity of carbon nanoparticle labeling were analyzed through the negative rate of incision margin, the volume of resected tumors, the detection rate of black-stained sentinel lymph nodes, the recurrence rate of ipsilateral breast, and postoperative survival.Results: In all, 32 patients underwent sentinel lymph node biopsy, 29 cases were detected (90.6%), the false-negative rate was 3.8% (1/26), and 0-4 sentinel lymph nodes (mean 1.8±1.1) were detected. A total of 26 patients underwent breast-conserving surgery, 5 underwent secondary excision, and 1 underwent subcutaneous adenectomy due to a positive margin. The minimum margin between the resected site and the infiltrated part was 1.0-2.1 cm (1.3±0.3 cm). The diameter of resected tumors ranged from 2.2 to 4.5 cm (3.1±0.6 cm). No recurrence or distant metastasis of ipsilateral breast tumors was observed during follow-up (the median follow-up time was 9 months).Conclusions: Ultrasound-assisted carbon nanoparticle labeling is effective for sentinel lymph node tracing before neoadjuvant chemotherapy and has a high detection rate for metastatic lymph nodes. During breastconserving surgery, it can determine the extent of tumor resection to achieve precision surgical treatment.

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Section: Discussionmentioning

confidence: 99%

Ultrasound-assisted carbon nanoparticle labeling of neoadjuvant chemotherapy for breast-conserving surgery in breast cancer

Lin¹,

Liu²,

Wang³

et al. 2023

Quant Imaging Med Surg

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“…Carbon nanoparticles are used in various fields, such as nanopharmacology, nanomedicine, and nanooncology, as they incorporate all the advantages of the nanotechnology industry, showing excellent absorption properties and the ability to aggregate [11]. Since the diagnosis and treatment of cancer are, at the moment, the most important problems in medicine, carbon nanoparticles have recently started to be used by surgeons in China for lymph node mapping in various operations carried out for malignancy, such as endometrial, breast, thyroid, gastric, and colorectal malignancies [12][13][14][15][16]. Carbon nanoparticles have been associated with an increased number of lymph nodes retrieved in surgery for the abovementioned malignancies, while they also improve the identification rate of small lymph nodes and can be used to trace sentinel lymph nodes in order to evaluate lymphatic metastasis [12,13].…”

Section: Introductionmentioning

confidence: 99%

The Role of Carbon Nanoparticles as Lymph Node Tracers in Colorectal Cancer: A Systematic Review and Meta-Analysis

Koimtzis,

Geropoulos,

Stefanopoulos

et al. 2023

IJMS

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Colorectal malignancies are the third-most common malignancies worldwide, with a rising incidence. Surgery remains the treatment of choice and adequate lymph node dissection is required for accurate staging. The objective of this study is to assess the use of carbon nanoparticles in lymph node tracing and resection in cases of colorectal cancer. For that purpose, we conducted a systematic review and meta-analysis of studies included in Medline, Scopus, Embase, Cochrane Library, and Google Scholar databases. In the end, ten studies with a total number of 1418 patients were included in the final statistical analysis. The meta-analysis carried out showed that the use of carbon nanoparticles results in an increased number of lymph nodes harvested (WMD 6.15, 95% CI 4.14 to 8.16, p < 0.001) and a higher rate of cases with more than 12 lymph nodes harvested (OR 9.57, 95% CI 2.87 to 31.96, p = 0.0002). As a consequence, we suggest that carbon nanoparticles are used on a wider scale and that future research focuses on assessing the association between their use and overall patient survival. This study is limited by the fact that all included studies originate from China and by the fact that certain oncologic parameters and long-term outcomes have not been taken into account in the analysis.

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“…Breast cancer is a malignant tumor that occurs at the site of the ductal epithelium and terminal ductal epithelium of the breast (1). On December 15, 2020, the World Health Organization International Agency for Research on Cancer released the latest global breast cancer data, showing that there were 2.26 million new cases of breast cancer worldwide in 2020, surpassing 2.2 million cases of lung cancer for the first time and becoming the "largest cancer in the world" (2,3).…”

Section: Introductionmentioning

confidence: 99%

Nano Carbon Tracing-based Treatment of Breast Cancer Lymphadenectomy and Nursing Intervention of Postoperative Lymphedema

Li¹,

Fu²,

Li³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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To investigate the tracing and therapeutic effects of carbon nanoparticles epirubicin (CNP-EPI) on axillary lymphadenectomy for breast cancer and postoperative lymphedema nursing intervention, a total of 60 breast cancer patients in Harbin Medical University Cancer Hospital were selected for the study subjects and randomly divided into group A (n=30) and group B (n=30). They were subcutaneously injected with 1 mL of CNP-EPI 1 day before surgery and 3 days before surgery, respectively, and underwent axillary lymph node dissection. Lymphedema nursing intervention and routine care were implemented in groups A and B, respectively. After adsorption of 2 mL of 6 mg/mL epirubicin by 1 mL carbon nanoparticles, epirubicin could be slowly released with a cumulative release rate of 64.7 %. The black staining rate was 80.2 % (341/425) in group A and 57.7 % (217/376) in group B, and the difference was statistically significant (P < 0.05). The black staining rate in metastatic lymph nodes was 73.1 % (23/52) in group A and 65.9 % (27/41) in group B (P > 0.05). The incidence rate of edema at 1, 3, and 6 months after operation in group A was significantly lower than that in group B (P < 0.05). Carbon nanoparticles have strong adsorption properties and slow drug release ability; subcutaneous injection of CNP-EPI axillary lymph nodes around the areola 1 day before surgery has a better lymphatic tracing effect; lymphedema nursing intervention can effectively reduce the incidence of prognostic lymphedema.

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Long-term tracing and staining of carbon nanoparticles for axillary lymph nodes in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy

Cited by 8 publications

References 18 publications

Ultrasound-assisted carbon nanoparticle labeling of neoadjuvant chemotherapy for breast-conserving surgery in breast cancer

Ultrasound-assisted carbon nanoparticle labeling of neoadjuvant chemotherapy for breast-conserving surgery in breast cancer

The Role of Carbon Nanoparticles as Lymph Node Tracers in Colorectal Cancer: A Systematic Review and Meta-Analysis

Nano Carbon Tracing-based Treatment of Breast Cancer Lymphadenectomy and Nursing Intervention of Postoperative Lymphedema

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