Long term treatment at gastric electrical stimulation is associated with changes in neuro enteric function

Abell, Thomas L.; Luo, Jiali; Rashed, Hani; Eaton, Paula; Voller, Guy; Familoni, Babajide O.

doi:10.1111/j.1572-0241.2000.02483.x

Cited by 2 publications

(1 citation statement)

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“…(vi) Modulation of the autonomic nervous system: There is evidence for enhanced vagal activity and decreased adrenergic effect. (29) and improved pancreatic exocrine function (30) in patients with pancreatic insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Gastric Electrical Stimulation Significantly Increases Canine Lower Esophageal Sphincter Pressure

et al. 2005

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This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the greater curvature of the stomach. A sleeve device measured LES pressure before, during, and after GES, and regulatory peptides were measured during fasting and after a meal. A consistent and significant rise in LES pressure was observed during GES, and it was sustained after GES was discontinued. Plasma concentration and area under the curve of pancreatic polypeptide, motilin, gastrin and neurotensin were not affected by GES. We conclude that acute low- and high-frequency GES significantly increases LES pressure. This effect may not be modulated by efferent vagal activity or release of regulatory peptides.

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Section: Discussionmentioning

confidence: 99%