Long-term treatment of atrophic vaginitis with low-dose oestradiol vaginal tablets

Vaginal Estrogen Preparations: A Review of Safety and Efficacy for Vaginal Atrophy

“…Subject numbers in the trials ranged from 20 2 to 251. 3 Study duration ranged from 2 weeks 4 to 1 year 5 (Table 1).…”

“…It was then withheld for 7 days, and the cycle was repeated. Casper and Estradiol ring and estriol pessary equivalent responder rates for parameter of Petri, 1999 10 "symptoms of urogenital atrophy," including vaginal dryness, pruritis, dyspareunia, dysuria, and urinary urgency; further details not given Chompootaweep OCP and CEE cream equivalent et al, 1998 11 Dugal et al, 2000 12 Vaginal estradiol tablets superior to estriol vagitories Eriksen, 1992 13 Vaginal estradiol tablet superior to placebo Eriksen, 1999 14 Estradiol ring superior to no-treatment controls Henriksson et al, 1994 16 Estradiol ring and estriol pessary equivalent Lose Casper and Estradiol ring led to higher proportion of responders vs. placebo Petri, 1999 10 Chompootaweep OCP and CEE cream equivalent et al, 1998 11 Dugal et al, 2000 12 Vaginal estradiol tablets more efficious than estriol cream Eriksen, 1992 13 Vaginal estradiol tablet superior to placebo Eriksen, 1999 14 Estradiol ring superior to no-treatment controls Henriksson et al, 1994 16 Estradiol ring and estriol pessary equivalent Lose and Englev, Estradiol ring and estriol pessary equivalent 2000 3 Mattson et al, 1989 2 Both 25 and 50 mg estradiol pessary gave relief in all subjects Mettler and Olsen, Twice-weekly equivalent to once-weekly vaginal estradiol tablet 1991 5 Nachtigall, 1995 20 Estradiol ring and vaginal CEE cream equivalent Pruritis Barentsen et al, 1997 8 Estradiol ring more efficacious than estriol cream Bygdeman and Swahn, Dienestrol cream equivalent to nonhormonal vaginal lubricant 1996 1 Dugal et al, 2000 12 Vaginal estradiol tablets and estriol vagitories equivalent Eriksen, 1999 14 Estradiol ring and estriol pessary equivalent Henriksson et al, 1994 16 No difference in change between estradiol ring and no-treatment controls Mattson et al, 1989 2 Estradiol ring and estriol pessary equivalent Both 25 and 50 mg estradiol pessary gave relief in all subjects Irritation or burning Bygdeman and Swahn, Dienestrol cream equivalent to nonhormonal vaginal lubricant 1996 1 Dugal et al, 2000 12 Vaginal estradiol tablets and estriol vagitories equivalent Mettler and Olsen, Twice-weekly superior to once-weekly vaginal estradiol tablet 1991 5 Nachtigall, 1995 20 Estradiol ring and vaginal CEE cream equivalent Rioux et al, 2000 23 Estradiol vaginal tablet equivalent to ...…”

“…Twice-weekly use of the tablets was more effective than onceweekly use. 5 The estradiol ring was equally effective as vaginal CEE cream in decreasing irritation or burning. Dienestrol cream was equivalent to a nonhormonal vaginal lubricant in relieving irritation or burning ( Table 2).…”

Sex and the bladder

“…Despite earlier fears, recent research has shown that continuous unopposed low dose oestrogen replacement therapy can be administered topically without significant risk of endometrial stimulation (Mettler & Olsen, 1991;Mattsson et al, 1989). Topical vaginal oestrogen can be administered as low dose oestradiol (Mettler & Olsen, 199 1;Erikson & Rasmussen, 1992) or oestriol (Kirkengen et aL, 1992;Iosif, 1992), avoiding the enterohepatic circulation and at doses low enough to cause minimal systemic side effects while adequately relieving urogenital atrophy and symptoms of frequency and urgency of micturition.…”

Vaginale Östrogentherapie bei Mammakarzinompatientinnen

“…Bezüglich der systemischen Absorption konnte bei Verabreichung einer Vaginaltablette mit 25 µg Östradiol lediglich eine geringe systemische Absorption bei weiterhin geringen Serumöstradiol-spiegeln <14 pg/ml nachgewiesen werden [17]. Beim Vergleich eines Vaginalrings, der Östradiol freisetzt, mit östradiolhal-tigen Vaginaltabletten konnten ebenfalls lediglich minimale Anstiege der Serumöst-radiolspiegel verzeichnet werden.…”