Long-Term Treatment of Multiple Sclerosis With Corticotrophin

Treatment of Acute Relapses in Multiple Sclerosis

“…The article references earlier publications by Fog [8] and J nsson et al [9], who previously described similar outcomes of ACTH treatment based on their clinical observations. These and other similar data provide evidence that ACTH gel is beneficial in the treatment of acute MS [10,11].…”

A trial of corticotrophin gelatin injection in acute optic neuritis

“…Although the results of the Cooperative Study (1970) in the U.S.A. tended to support this, the benefits over placebo were marginal and it was concluded that, for the individual patient with an acute exacerbation of multiple sclerosis, there is 'little evidence to justify the enthusiastic administration of ACTH'. The value of ACTH in chronic multiple sclerosis is even more doubtful, benefit being claimed by some (Alexander and Cass, 1963) and denied by others (Rinne et al, 1968;Millar et al, 1967).…”

A 29-Year-Old Man With Multiple Sclerosis

“…Whether the overall degree of recovery is improved or the long-term course is altered is not known. [73][74][75] Intravenous methylprednisolone is the preferred treatment because of rapid onset of action, consistent benefits, and relatively few adverse effects. 74,76 For moderate-to-severe relapses, methylprednisolone, 1000 mg, by intravenous infusion daily for 3 to 5 days followed by oral prednisone tapering from 60 mg/d over 12 days is effective in accelerating neurologic recovery.…”