Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: The Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS)

Östling, Gerd; Gonçalves, Isabel; Wikstrand, John; Berglund, Göran; Nilsson, Jan; Hedblad, Bo

doi:10.1016/j.atherosclerosis.2010.12.031

Cited by 21 publications

(10 citation statements)

References 30 publications

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“…However, GSM values differ also in studies including similar populations. The same large differences in GSM values could be found in two studies on patients with asymptomatic plaques (Lind & Lind, 2011;Ostling et al, 2011). In the other two studies, Adobe Photoshop â was used, however, with different values for standardization of the grey scale.…”

Section: Discussionsupporting

confidence: 52%

Comparison of grey scale median (GSM) measurement in ultrasound images of human carotid plaques using two different softwares

Östling

Persson

Hedblad

et al. 2013

Clin Physio Funct Imaging

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Grey scale median (GSM) measured on ultrasound images of carotid plaques has been used for several years now in research to find the vulnerable plaque. Centres have used different software and also different methods for GSM measurement. This has resulted in a wide range of GSM values and cut-off values for the detection of the vulnerable plaque. The aim of this study was to compare the values obtained with two different softwares, using different standardization methods, for the measurement of GSM on ultrasound images of carotid human plaques. GSM was measured with Adobe Photoshop(®) and with Artery Measurement System (AMS) on duplex ultrasound images of 100 consecutive medium- to large-sized carotid plaques of the Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS). The mean values of GSM were 35·2 ± 19·3 and 55·8 ± 22·5 for Adobe Photoshop(®) and AMS, respectively. Mean difference was 20·45 (95% CI: 19·17-21·73). Although the absolute values of GSM differed, the agreement between the two measurements was good, correlation coefficient 0·95. A chi-square test revealed a kappa value of 0·68 when studying quartiles of GSM. The intra-observer variability was 1·9% for AMS and 2·5% for Adobe Photoshop. The difference between softwares and standardization methods must be taken into consideration when comparing studies. To avoid these problems, researcher should come to a consensus regarding software and standardization method for GSM measurement on ultrasound images of plaque in the arteries.

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Section: Discussionsupporting

confidence: 52%

Comparison of grey scale median (GSM) measurement in ultrasound images of human carotid plaques using two different softwares

Östling

Persson

Hedblad

et al. 2013

Clin Physio Funct Imaging

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“…The risk of rupture of an atherosclerotic plaque is not only dependent on the plaque size but on the composition of the plaque. 17 Vulnerable plaque is typically characterized by a thin fibrous cap and increased accumulation of lipids and inflammatory cells. 17 This plaque morphology can be assessed as gray scale median (GSM).…”

Section: Outcome Measuresmentioning

confidence: 99%

“…17 Vulnerable plaque is typically characterized by a thin fibrous cap and increased accumulation of lipids and inflammatory cells. 17 This plaque morphology can be assessed as gray scale median (GSM). Thus, we also explored the effects of long-term intensive lipid-lowering therapy on GSM.…”

Section: Outcome Measuresmentioning

confidence: 99%

Effect of Long-Term Intensive Lipid-Lowering Therapy With Rosuvastatin on Progression of Carotid Intima-Media Thickness

Nohara

Daida

Hata

et al. 2013

Circ J

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“…This raises the possibility that IM-GSM might be amenable to beneficial modification (increased IM-GSM) by controlling BMI and related CV risk factors. A 3-year treatment with a β-blocker showed a significant increase in plaque echogenicity (Ostling et al 2011). A post-hoc analysis of the METEOR study has also suggested a beneficial effect of 2-year rosuvastatin treatment on IM-GSM in individuals with low IM-GSM at baseline .…”

Section: Discussionmentioning

confidence: 95%

P2.17 Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke

Aizawa

Elyas

Adingupu

et al. 2013

ARTRES

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ABSTRACT:Grey-scale median of the common carotid artery intima-media complex (IM-GSM) characterizes the arterial wall composition and low IM-GSM is associated with an increased cardiovascular mortality in the elderly. We aimed to determine differences in IM-GSM between a cohort with cerebrovascular disease and a healthy cohort. Eighty-two healthy individuals (CTRL: 63.2±8.7yrs) and 96 patients with either stroke or transient ischemic attacks (CRVD: 68.6±9.8yrs) were studied. Common carotid artery intima-media thickness (cIMT) and IM-GSM obtained by ultrasound were analysed using semi-automated edgedetection software. IM-GSM was significantly lower in CRVD than CTRL (106±30 vs 124±27 au, p<0.001). IM-GSM was similar between the infarct and non-infarct sides in CRVD. In the pooled cohort of all participants, the lower the quartile of IM-GSM, the greater cIMT and carotid artery remodelling were. These results suggest the presence of an altered atherosclerotic phenotype in the intima-media complex of CVRD patients that can be detected by ultrasound.

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Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: The Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS)

Cited by 21 publications

References 30 publications

Comparison of grey scale median (GSM) measurement in ultrasound images of human carotid plaques using two different softwares

Comparison of grey scale median (GSM) measurement in ultrasound images of human carotid plaques using two different softwares

Effect of Long-Term Intensive Lipid-Lowering Therapy With Rosuvastatin on Progression of Carotid Intima-Media Thickness

P2.17 Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke

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