Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats

Soufi, Farhad Ghadiri; Vardyani, Mina; Sheervalilou, Roghayeh; Mohammadi, Mustafa; Somi, Mohammad Hussein

doi:10.4149/gpb_2012_039

Cited by 47 publications

(45 citation statements)

References 24 publications

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“…In the present study, although resveratrol could not increase the blood insulin concentration in diabetic rats, it prevented from pancreatic insulin depletion and enhanced the peripheral glucose utilization. Improvement in glucose metabolism in turn prevents from degradation of proteins and lipids from their reservoirs and attenuates the body weight loss during diabetes [11,12,17]. Improvement in insulin sensitivity after 4-week resveratrol administration has been also recently reported in type 2 diabetic patients, as well as in adults with impaired glucose tolerance [18,19].…”

Section: Discussionmentioning

confidence: 94%

“…Blood glucose and body weight Anti-hyperglycemic effect of resveratrol has been documented by several studies [5,12,13]. It is believed that resveratrol ameliorates diabetes-mediated hyperglycemia through insulin--dependent and insulin-independent pathways [5].…”

Section: Discussionmentioning

confidence: 99%

“…Citrate buffer was injected alone in control rats. After 48 h blood glucose levels were measured using glucometer (Arkray, Kyoto, Japan) and the rats with blood glucose levels higher than 250 mg/dL were included to the protocol as diabetic rats [12]. All manipulations were held in the morning.…”

Section: Experimental Designmentioning

confidence: 99%

“…86-23, revised 1996) and ARRIVE guidelines for the care and use of animals approved by the Ethics Committee for the Use of Animals in Research at Ahvaz Jundishapur University of Medical Sciences [11]. Type 2 diabetes was induced by injection of streptozotocin (50 mg/ /kg; IP) dissolved in 0.1 M of citrate buffer (pH 4.5), 15 min after the prescription of nicotinamide (110 mg/kg; IP) in 12 h fasted rats [12,13]. Citrate buffer was injected alone in control rats.…”

Section: Experimental Designmentioning

confidence: 99%

“…Resveratrol treatment (Cayman chem., Ann Arbor, MI, USA) was carried out orally in aqueous solution for 4 months [12]. The dosage (5 mg/kg) was regulated every week.…”

Section: Majid Mohammadshahi Et Al Chronic Resveratrol Intake and Dmentioning

confidence: 99%

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Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

2014

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8-isoprostane, 6.03 ± 0.87 vs. 8.49 ± 0.52 µmol, p < 0.05 for nitrite/nitrate, and 0.44 ± 0.03 vs. 0.59 ± 0.04, p < 0.05 for oxidized/reduced glutathione ratio), nuclear factor kappa B activity (0.37 ± 0.09 vs. 0.60 ± 0.11, p < 0.05) and apoptosis rate (0.98 ± 0.28 vs. 1.63 ± 0.16, p < 0.05). Moreover, it improved left ventricular developed pressure (72.46 ± 8.16 vs. 52.01 ± 11.32 mm Hg, p < 0.05) and coronary flow (14.08 ± 1.09 vs. 11.75 ± 1.43 mL/ /min × g, p < 0.05). Conclusions: These beneficial cardioprotective observations suggest that treatment with resveratrol can potentially delay or attenuate the progression of diabetes-related cardiac complications. (Cardiol J 2014; 21, 1: 39-46)

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

“…Resveratrol treatment (Cayman chem., Ann Arbor, MI, USA) was carried out orally in aqueous solution for 4 months [12]. The dosage (5 mg/kg) was regulated every week.…”

Section: Majid Mohammadshahi Et Al Chronic Resveratrol Intake and Dmentioning

confidence: 99%

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Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

2014

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Spectroscopic evidences of toxic trans‐crotonaldehyde trapped and transformed by resveratrol to prevent the damage of mitochondrial DNA

Chen

et al. 2017

IUBMB Life

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The purpose of this study is to probe the spectroscopic evidences of toxic trans-crotonaldehyde (TCA) trapped and transformed by resveratrol (Res) to prevent the damage of mitochondrial DNA. In aldehyde dehydrogenase (ALDH) at the different pH or mitochondria, the spectroscopic characteristics of TCA trapped and transformed by Res were observed by means of both UV-vis and Raman spectra. When Res interacted with TCA, TCA peak at 316 nm immediately disappeared while Res main peak at 305 nm and shoulder peak at 320 nm were dramatically changed, Raman peaks of TCA at 1,688 cm assigned to CHO and 1,641 cm affiliated to CC were strikingly shifted, Raman peaks of Res itself were significantly displaced or disappeared, especially in mitochondria and ALDH at different pH. The active groups of Res were the OH at C and C . The results of theoretical calculations are in agreement on the whole with the experimental data. The Res plays undoubtedly an important role via the structural change in TCA. The toxic CHO of TCA was effectively trapped and transformed by Res by means of itself OH at C and C . The mitochondrial alkaline microenvironment and ALDH promoted the elimination of toxic TCA. © 2017 IUBMB Life, 69(7):500-509, 2017.

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Effects of Resveratrol on the Expression and DNA Methylation of Cytokine Genes in Diabetic Rat Aortas

Lou

Wang

Xia

et al. 2014

Arch. Immunol. Ther. Exp.

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This paper studies the expression of proinflammatory cytokines such as IL-1β, IL-6, TNF-α, and IFN-γ and anti-inflammatory cytokines such as IL-10 in diabetic rat aortas, the effects of resveratrol on these cytokines, and the potential epigenetic mechanisms involved. The experiment was performed on rats divided into four groups: normal group (NC), normal interventional group (NB), diabetic group (DM), and diabetic interventional group (DB). The NB and DB groups were treated with resveratrol. After more than 3 months, the rats' aortas were removed and analyzed for cytokines by using immunohistochemistry, Western blotting, real-time PCR, and methylation-specific PCR. Histological localization of these cytokines was mainly found in the arterial intima of diabetic rats. The protein and mRNA expression levels of IL-1β, IL-6, TNF-α, and IFN-γ were significantly higher in the DM group than in the NC group (p < 0.05), whereas in the resveratrol-treated groups (NB and DB), the levels were relatively lower than those in the corresponding groups. The DM group showed reduced levels of DNA methylation at the specific cytosine phosphate guanosine sites of IL-1β, IL-6, TNF-α, and IFN-γ, relative to those in the NC group (p < 0.01), and these levels were increased by resveratrol. In contrast, IL-10 was dramatically methylated and showed decreased expression in response to high glucose, and resveratrol reversed this effect. These results demonstrate that the inflammatory response is involved in diabetic macroangiopathy. Resveratrol inhibits the expression of proinflammatory cytokines and thus may have a protective effect on the aorta in hyperglycemia. Thus, DNA methylation, an epigenetic gene silencing signal, may be responsible for these two phenomena.

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Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats

Cited by 47 publications

References 24 publications

Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

Chronic resveratrol administration improves diabetic cardiomyopathy in part by reducing oxidative stress

Spectroscopic evidences of toxic trans‐crotonaldehyde trapped and transformed by resveratrol to prevent the damage of mitochondrial DNA

Effects of Resveratrol on the Expression and DNA Methylation of Cytokine Genes in Diabetic Rat Aortas

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