Long-term Trial of Disodium Cromoglycate and Isoprenaline in Children with Asthma

Inhaled steroids compared with disodium cromoglycate in preschool children with episodic viral wheeze

“…These findings, however, could not be confirmed by other investigators. 4,5 Kerrebijn et al 3 reported a significant decrease in bronchial responsiveness after 6 months in 12 patients receiving 0.2 mg budesonide three times a day. In our group of preschool children with virally induced wheezing, a 2-month treatment period with inhaled DSCG or BDP did not decrease bronchial responsiveness.…”

“…4,5 Wheezing in preschool children is treated with the same anti-inflammatory drugs as in older children, although viral infections rather than atopy are the main provocative cause of symptoms in preschool children. Studies on clinical efficacy in preschool children treated with inhaled steroids 6,7 or cromones 2,8 are equivocal.…”

Exercise‐Induced Asthma

“…In the studies of asthmatic children by Siiverman (38) which we reviewed (4), there was no clear correlation between the severity of EIA and the severity of the asthma as judged by recent symptoms, asthma diary scores or home recording of PEFR over the preceding month. Moreover, Silverman et al, (41) found no improvement in EIA in a group of asthmatic children under treatment which considerably improved their clinical and physiological condition. On the other hand, Haynes et al (25) noticed a greater degree of abnormality in several tests of lung function after exercise in adults with more abnormal resting values, but commented, that because of the variance, it would be difficult to predict the behaviour of a given individual, EIA seemed at first to be an ideal model for studying the action of drugs used to treat asthma, since many of them can be shown to block EIA quite effectively {Fig, 6).…”

Effect of Long-Term Treatment with Sodium Cromoglycate on Non-Specific Bronchial Hyperreactivity in Non-Atopic Patients with Chronic Bronchitis

“…Whilst initially described as a specific inhibitor of reaginic antibody-antigen mechanisms [1] it became apparent from further laboratory and clinical studies, that in man, pre-treatment with sodium cromoglycate exerted a protective effect against both allergic and non-allergic bronchial challenge [5][6][7][8][9][10][11][12][13][14][15][16][17], and that clin ically the drug was a safe and effective agent in the treatment of bronchial asth ma, whether or not allergic factors could be shown to contribute to the aetiology [21][22][23][24][25], To date, pre-treatment with sodium cromoglycate has been shown to inhibit the early (immediate) and late (non-immediate) asthmatic response to inhaled al lergen [7,8] and to inhibit bronchocon-…”

“…There was a washout period of 12 h between the administration of the last dose of sodium cromoglycate and the second fog challenge. The possible mechan isms involved and the clinical significance of these findings are discussed.Following the introduction of sodium cromoglycate as a novel prophylactic agent in the treatment of bronchial asth ma, many investigators have reported on the pharmacological properties [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and clinical activity [21][22][23][24][25] of this drug.Whilst initially described as a specific inhibitor of reaginic antibody-antigen mechanisms [1] it became apparent from further laboratory and clinical studies, that in man, pre-treatment with sodium cromoglycate exerted a protective effect against both allergic and non-allergic bronchial challenge [5][6][7][8][9][10][11][12][13][14][15][16][17], and that clin ically the drug was a safe and effective agent in the treatment of bronchial asth ma, whether or not allergic factors could be shown to contribute to the aetiology [21][22][23]…”