Long-Term Use of Mesalamine (Rowasa) Suppositories in Remission Maintenance of Ulcerative Proctitis

Hanauer, Stephen B.; Good, Larry; GOODMAN, MORRIS; Pizinger, R.; Strum, Williamson B.; Lyss, C; Haber, Gregory B.; Williams, C. N.; Robinson, Malcolm

doi:10.1111/j.1572-0241.2000.02185.x

Cited by 88 publications

(21 citation statements)

References 24 publications

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“…Mesalamine suppositories in doses of 500 mg daily or twice daily are eff ective in maintaining remission with an apparent doseresponse relationship; only 10 % of patients treated with 500 mg twice daily relapsed at 1 year, compared with a relapse rate of 36 % with once daily dosing ( 124,125 ). Mesalamine enemas in doses of 2 -4 g maintained remission when administered daily (78 % eff ective), every other day (72 % eff ective), or even as infrequently as every third day (65 % eff ective) ( 77,78 ).…”

Section: (Evidence A) When All Of These Measures Fail To Maintain Rementioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

1,156

977

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Guidelines for clinical practice are aimed to indicate preferred approaches to medical problems as established by scientifi cally valid research. Double-blind placebo controlled studies are preferable, but compassionate-use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. When only data that will not withstand objective scrutiny are available, a recommendation is identifi ed as a consensus of experts. Guidelines are applicable to all physicians who address the subject regardless of specialty training or interests and are aimed to indicate the preferable but not necessarily the only acceptable approach to a specifi c problem. Guidelines are intended to be fl exible and must be distinguished from standards of care, which are infl exible and rarely violated. Given the wide range of specifi cs in any healthcare problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. Guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee and approved by the board of trustees. Each has been intensely reviewed and revised by the Committee, other experts in the fi eld, physicians who will use them, and specialists in the science of decision analysis. The recommendations of each guideline are therefore considered valid at the time of composition based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at a time established and indicated at publication to assure continued validity. The recommendations made are based on the level of evidence found. Grade A recommendations imply that there is consistent level 1 evidence (randomized controlled trials), grade B indicates that the evidence would be level 2 or 3, which are cohort studies or case -control studies. Grade C recommendations are based on level 4 studies, meaning case series or poor-quality cohort studies, and grade D recommendations are based on level 5 evidence, meaning expert opinion.

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Section: (Evidence A) When All Of These Measures Fail To Maintain Rementioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

1,156

977

View full text Add to dashboard Cite

show abstract

“…In conclusion, in maintenance treatment, mesalamine suppository treatments were found to be superior to placebo, mesalamine enema treatment was found to be superior to mesalamine oral treatment, and combined treatment (oral + rectal) was found to be superior to oral treatment (1,(12)(13)(14)17,18). Budesonide enema was not found to be effective in maintenance treatment (15).…”

Section: Resultsmentioning

confidence: 91%

Should maintenance therapy be performed in ulcerative proctitis? How long should it be continued?

Yönal

Hatemi²,

Kaymakoğlu³

2012

Turk J Gastroenterol

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“…A recent Cochrane review reported that sulfasalazine was superior in the maintenance setting [69]. A recent meta-analysis including seven randomized-controlled trials (n = 555 patients) showed that topical mesalazine was effective in preventing relapse of distal UC [12,70]. In the study, 500 mg mesalazine b.i.d.…”

Section: Maintenance Treatmentmentioning

confidence: 99%

Ulcerative proctitis: an update on the pharmacotherapy and management

Gecse

Lakatos

2014

Expert Opinion on Pharmacotherapy

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Long-Term Use of Mesalamine (Rowasa) Suppositories in Remission Maintenance of Ulcerative Proctitis

Abstract: The results demonstrate that mesalamine suppositories are efficacious, well tolerated, and safe for the long-term maintenance of remission of ulcerative proctitis.

Cited by 88 publications

References 24 publications

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Should maintenance therapy be performed in ulcerative proctitis? How long should it be continued?

Ulcerative proctitis: an update on the pharmacotherapy and management

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