Long‐term Use of Prazosin in Combination or Alone for Treating Hypertension

Stokes, Gordon S.; Gain, J M; Mahony, J. F.; Raftos, John; Stewart, J. H.

doi:10.5694/j.1326-5377.1977.tb107754.x

Cited by 31 publications

(4 citation statements)

References 9 publications

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“…This study has shown that after careful dose titration of prazosin, a blood pressure reduction of the same magnitude as with metoprolol can be obtained. In primary hypertension the effect of prazosin has been reported to be stable over time periods of 5 years and more (16,17). Thus, after dose titration prazosin seems to be equivalent to metoprolol in its effect on blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Are Effects of Antihypertensive Treatment on Lipoproteins Merely “Side‐effects”?

Lithell

Haglund

Granath

et al. 1988

Journal of Internal Medicine

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Thirty‐seven patients with a supine systolic blood pressure >160 and/or a diastolic blood pressure >95 mmHg were enrolled in the study and treated for 6 months with prazosin and 6 months with metoprolol (in random order). Neither the systolic nor the diastolic blood pressures differed after the two types of treatment (median difference 0/0 mmHg). The mean and median differences in serum cholesterol, however, were 0.4 and 0.3 mmol/l respectively, which were 9 and 5% of the pretreatment values. The corresponding differences in the atherogenic index (in which cholesterol in high density lipoproteins is integrated) were 10 and 8% of the pretreatment values. This difference in the metabolic response to the two drugs at the same blood pressure level is most probably of importance in the long‐term prevention of ischaemic heart disease, for which high levels of serum cholesterol and atherogenic index are major risk factors.

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Section: Discussionmentioning

confidence: 99%

Are Effects of Antihypertensive Treatment on Lipoproteins Merely “Side‐effects”?

Lithell

Haglund

Granath

et al. 1988

Journal of Internal Medicine

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show abstract

“…Longitudinal survey of healthy geriatric home residents (ages [60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79] followed 10 years.…”

Section: Retrospective Practice Analysis Of Diastolic Hypertension Comentioning

confidence: 99%

“…The cardiac stimulation and tachycardia seen in younger patients treated with hydralazine may be less troublesome in older patients due to blunted baroreceptor sensitivity. Prazosin, a peripheral alpha-blocking agent which acts primarily as a vasodilator, does not decrease cardiac output, does decrease peripheral resistance, and usually does not cause orthostatic hypotension or tachycardia (75)(76)(77). The troublesome first-dose phenomenon can be avoided by beginning therapy with low doses given at bedtime (78).…”

Section: Recommendations For Therapymentioning

confidence: 99%

Hypertension in the Elderly: The Time Has Come to Treat

Radin

Black

1981

J American Geriatrics Society

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Both pure systolic, and systolic plus diastolic hypertension are risk factors for cerebrovascular and cardiovascular disease in patients over 65 years old, but the efficacy of antihypertensive therapy in preventing the complications of hypertension in the elderly has been questioned. The risks associated with such therapy seem to have been overemphasized. Although the evidence is incomplete, elderly patients should be treated when the systolic blood pressure exceeds 160 mm Hg or the diastolic pressure exceeds 95 mm Hg, or both. A revised stepped-care approach, with use of vasodilating agents as the Step-2 drugs, is proposed.

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“…They show either significant antagonism in the antihypertensive effect of clonidine and sotalol (I) or no deleterious interaction between clonidine and propranolol (2,3,4) or clonidine and atenolol (4). The combined use of clonidine and the al-blocker, prazosin, has resulted in no deleterious effects (4)(5)(6)(7).…”

mentioning

confidence: 99%

Interaction of Clonidine and Labetalol in Hypertension

Lilja

1983

Journal of Internal Medicine

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ABSTRACT. Concomitant administration of the α2‐adrenoceptor agonist, clonidine, and the α1‐ and non‐selective β‐adrenoceptor antagonist, labetalol, was studied in 12 hypertensive outpatients treated with thiazide diuretics. Clonidine, 0.15 mg b.i.d., effectively lowered supine, standing and isometric blood pressure values when administered to patients on cyclothiazide, 2.5 mg q.d. Addition of labetalol, 200 mg b.i.d., to the diuretic—clonidine treatment resulted in further reduction of blood pressure at rest both in the supine and standing position. In contrast, during isometric work, addition of labetalol to the diuretic‐clonidine regimen did not exhibit the same additive antihypertensive effect. When clonidine was given in a dose of 0.3 mg once daily in the evening and the other two drugs as previously, the same antihypertensive effect was observed in the afternoon. Labetalol did not provoke new side‐effects of its own.

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Long‐term Use of Prazosin in Combination or Alone for Treating Hypertension

Cited by 31 publications

References 9 publications

Are Effects of Antihypertensive Treatment on Lipoproteins Merely “Side‐effects”?

Are Effects of Antihypertensive Treatment on Lipoproteins Merely “Side‐effects”?

Hypertension in the Elderly: The Time Has Come to Treat

Interaction of Clonidine and Labetalol in Hypertension

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