Long‐term use of zopiclone, zolpidem and zaleplon among Danish elderly and the association with sociodemographic factors and use of other drugs

Andersen, Ane Birgitte Telén; Frydenberg, Morten

doi:10.1002/pds.2104

Cited by 27 publications

(44 citation statements)

References 16 publications

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“…Older age was a strong predictor for long-term use of benzodiazepines, which is consistent with previous studies (Andersen and Frydenberg, 2011;Cunningham et al, 2010;Demyttenaere et al, 2008;Fang et al, 2009). It is possible that these findings are partly explained by other health problems or co-morbidities in older age.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, the primary health care centres were located in urban and rural areas as well as in both the Southern and Northern parts of Stockholm The following covariates were included in the model: age, gender, country of origin, income, education, social welfare and marital status. These covariates were included because previous research has shown that sociodemographic factors are related to psychiatric disorders (Andersen and Frydenberg, 2011;Bayard-Burfield et al, 2001;Demyttenaere et al, 2008;Fang et al, 2009;Hjern, 2001;Quigley et al, 2006;Sonnenberg et al, 2012). Age was divided into five categories: 25-44, 45-64, 65-74, and 85+ years.…”

Section: Methodsmentioning

confidence: 99%

“…Former studies have been able to establish that individual socio-demographic factors are associated with psychiatric disorders, such as depression, anxiety and insomnia (Andersen and Frydenberg, 2011;Bayard-Burfield et al, 2001;Demyttenaere et al, 2008;Fang et al, 2009;Hjern, 2001;Quigley et al, 2006;Sonnenberg et al, 2012). Former studies have also attempted to characterize individual socio-demographic factors associated with the occurrence of long-term use of benzodiazepines.…”

Section: Introductionmentioning

confidence: 99%

“…Former studies have also attempted to characterize individual socio-demographic factors associated with the occurrence of long-term use of benzodiazepines. Some of the most consistent predictors of long-term use of benzodiazepines are older age (Andersen and Frydenberg, 2011;Cunningham et al, 2010;Demyttenaere et al, 2008;Fang et al, 2009) and low socio-economic status (Andersen and Frydenberg, 2011;Demyttenaere et al, 2008;Sonnenberg et al, 2012;Zandstra et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…A slight female-associated long-term use has also been observed (Andersen and Frydenberg, 2011;Fang et al, 2009). Being married and having social support have been shown to be associated with decreased benzodiazepine use in general (Andersen and Frydenberg, 2011) Socio-demographic factors and benzodiazepines 5 but the association between these factors and long-term use of benzodiazepines is unknown.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Socio-demographic factors and long-term use of benzodiazepines in patients with depression, anxiety or insomnia

Sjöstedt

Sundquist

2017

Psychiatry Research

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Socio-demographic factors and long-term use of benzodiazepines in patients with depression, anxiety or insomnia

Sjöstedt

Sundquist

2017

Psychiatry Research

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Prescription Patterns and Predisposing Factors of Benzodiazepine and Z‐Hypnotic Use During Pregnancy: A Nationwide Cohort Study

Meng,

Lin,

Chuang

et al. 2024

Pharmacoepidemiology and Drug

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PurposeThe use of benzodiazepines and Z‐hypnotics during pregnancy has raised significant concerns in recent years. However, there are limited data that capture the prescription patterns and predisposing factors in use of these drugs, particularly among women who have been long‐term users of benzodiazepines and Z‐hypnotics before pregnancy.MethodsThis population‐based cohort study comprised 2 930 988 pregnancies between 2004 and 2018 in Taiwan. Women who were dispensed benzodiazepines or Z‐hypnotics during pregnancy were identified and further stratified into groups based on their status before pregnancy: long‐term users (with a supply of more than 180 days within a year), short‐term users (with a supply of less than 180 days within a year), and nonusers. Trends in the use of benzodiazepines or Z‐hypnotics and concomitant use with antidepressants or opioids were assessed. Logistic regression models were utilized to identify factors associated with use of these drugs during pregnancy, and interrupted time series analyses (ITSA) were employed to evaluate utilization patterns of these drugs across different pregnancy‐related periods.ResultsThe overall prevalence of benzodiazepine and Z‐hypnotic use was 3.5% during pregnancy. Among prepregnancy long‐term users, an upward trend was observed. The concomitant use of antidepressants or opioids among exposed women increased threefold (from 8.6% to 23.1%) and sixfold (from 0.3% to 1.7%) from 2004 to 2018, respectively. Women with unhealthy lifestyle behaviors, such as alcohol abuse (OR 2.48; 95% CI, 2.02–3.03), drug abuse (OR 10.34; 95% CI, 8.46–12.64), and tobacco use (OR 2.19; 95% CI, 1.96–2.45), as well as those with psychiatric disorders like anxiety (OR 6.99; 95% CI, 6.77–7.22), insomnia (OR 15.99; 95% CI, 15.55–16.45), depression (OR 9.43; 95% CI, 9.07–9.80), and schizophrenia (OR 21.08; 95% CI, 18.76–23.69), and higher healthcare utilization, were more likely to use benzodiazepines or Z‐hypnotics during pregnancy. ITSA revealed a sudden decrease in use of benzodiazepines and Z‐hypnotics after recognition of pregnancy (level change −0.55 percentage point; 95% CI, −0.59 to −0.51). In contrast, exposures to benzodiazepines and Z‐hypnotics increased significantly after delivery (level change 0.12 percentage point; 95% CI, 0.09 to 0.16).ConclusionsIn this cohort study, an increased trend of benzodiazepine and Z‐hypnotic use during pregnancy among prepregnancy long‐term users, as well as concomitant use with antidepressants or opioids were found. The findings have highlighted the existence of various risk factors associated with the use of these drugs during pregnancy. Utilization patterns varied across different stages of pregnancy, highlighting the need for prescription guidelines and educational services for women using these drugs during pregnancy.

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Long‐term benzodiazepines and z‐drug prescribing in Australian general practice between 2011 and 2018: A national study

Woods

Begum

González‐Chica

et al. 2021

Pharmacology Res & Perspec

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Despite reducing benzodiazepine prescribing, benzodiazepine‐involving deaths have substantially increased in Australia. This study aimed to explore patterns in long‐term prescribing of medications (benzodiazepine and z‐drugs [BZD]) used for sleep‐issues/insomnia in Australia to better understand these changes. Open cohort study using de‐identified electronic health records of 1 414 593 adult patients regularly attending 404 Australian general practices from 2011 to 2018 (MedicineInsight). We used logistic regression adjusted for patient and practice characteristics to; (1) estimate long‐term BZD prescribing prevalence (≥3 prescriptions in 6 months) and the associated sociodemographic factors, and (2) Poisson regression to compute annual changes in prescribing rates. Long‐term BZD prescribing changed from 4.4% in 2011 to 5.8% in 2015, remaining relatively stable until 2018 (annual increase +2.5% [95% CI +2.0%;+3.0%]). Long‐term BZD prescribing in any year was up to six times more likely in elderly rather than in younger patients and 30%–43% more prevalent in females, or patients living in or attending a practice located in more disadvantaged areas. The increase was more pronounced among males, adults aged 35–49 years, and individuals living in advantaged areas. The median duration among incident cases decreased from 1183 to 322 days between 2011 and 2017, and was up to 197 days longer among elderly females than males. Despite a slight increase and recent stability in long‐term BZD prescribing, the higher rates and durations among elderly patients, women, or those living in more disadvantaged areas are concerning and highlights the need for interventions that reduce the potential harms of long‐term BZD use in vulnerable groups.

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Long‐term use of zopiclone, zolpidem and zaleplon among Danish elderly and the association with sociodemographic factors and use of other drugs

Abstract: The results indicate that the guidance for length of use is not followed. Long-term use of zopiclone, zolpidem and zaleplon is associated with sociodemographic factors and use of other drugs, particularly from ATC group N.

Cited by 27 publications

References 16 publications

Socio-demographic factors and long-term use of benzodiazepines in patients with depression, anxiety or insomnia

Socio-demographic factors and long-term use of benzodiazepines in patients with depression, anxiety or insomnia

Prescription Patterns and Predisposing Factors of Benzodiazepine and Z‐Hypnotic Use During Pregnancy: A Nationwide Cohort Study

Long‐term benzodiazepines and z‐drug prescribing in Australian general practice between 2011 and 2018: A national study

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