Long-term virologic outcomes following bariatric surgery in patients with HIV

Zivich, Steven; Cauterucci, Margaret; Allen, S; Vetter, Marion L.; Vinnard, Christopher

doi:10.1016/j.orcp.2015.09.002

Cited by 14 publications

(5 citation statements)

References 10 publications

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“…Of the 78 patients with HIV infection identified in the literature who underwent bariatric surgery, 15% of patients had some form of complication. These complications were unrelated to HIV, most commonly minor, and generally occurred during the early postoperative period with a limited number of patients experiencing a complication one‐year after surgery . Of these patients being treated for HIV in whom viral load data were reported, 96% (45/47) remained virally suppressed following bariatric surgery .…”

Section: Discussionmentioning

confidence: 99%

“…after surgery. 10,17,22,26,36,[49][50][51][52][53][54] Of these patients being treated for HIV in whom viral load data were reported, 96% (45/47) remained virally suppressed following bariatric surgery. 10,17,22,26,36,51,53 One individual who did not achieve viral suppression was maintained on dolutegravir monotherapy, which is not a recommended treatment strategy according to the DHHS guidelines for antiretroviral use in adults.…”

Section: Raltegravirmentioning

confidence: 99%

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Antiretroviral considerations in HIV-infected patients undergoing bariatric surgery

et al. 2018

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SummaryWhat is known and objective: With the advent of antiretroviral therapy and the resultant decrease in mortality among adults living with human immunodeficiency virus (HIV), there is now an increased incidence of obesity and obesity-related comorbidities in these patients. Bariatric surgery is becoming an increasingly common Results: Several case series and case reports have been published which demonstrate minimal risk of complications and maintenance of virologic suppression in the vast majority of patients. Bariatric surgery appears to be an effective mechanism for assistance in controlling obesity in patients infected with HIV; however, numerous factors may impact the safe and effective use of antiretroviral therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Raltegravirmentioning

confidence: 99%

Antiretroviral considerations in HIV-infected patients undergoing bariatric surgery

et al. 2018

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“…Zivich et al 57 performed a retrospective cohort study of HIV-infected patients who underwent bariatric surgery while receiving care at the Partnership Comprehensive Care Practice (PCCP), a multidisciplinary HIV clinic affiliated with Drexel UniversityCollege of Medicine. They included all HIV-infected patients who underwent AGB, SG, or RYGB between January 2005, and July 2014.…”

Section: Bariatric Surgery In Hiv-infected Patientsmentioning

confidence: 99%

Bariatric surgery in HIV-infected patients: review of literature

Silva¹

2017

International Journal of Nutrology

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Obesity is now a common problem among HIV-infected patients receiving antiretroviral therapy (ART). Until recently, HIV infection has been considered a contraindication to bariatric surgery for various reasons. Insurance carriers have considered HIV a terminal disease, and surgeons have been reluctant to operate HIV-infected patients because of this, as well as the associated risk of infectious transmissions, although this has been changing. Gastric bypass surgery may be an option for some patients who have failed diet and therapeutic lifestyle changes, modification in ART or other treatment modalities for HIV/ART-related lipohypertrophy and obesity. However, few data are available regarding HIV-related outcomes after such surgery and its impact on ART tolerability. The aim of this study is to review bariatric surgery in HIV-infected patients.

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“…1,2 Of the estimated 1.2 million Americans living with HIV, approximately 30%-40% are considered overweight or obese. 3 Obesity, defined as a body mass index (BMI) ≥30 kg/m 2 , may impact the health of PLWH. 4 Not only does it impede physical activity and quality of life, it increases mortality rates, risk of comorbidities, and is one of the largest causes of preventable chronic diseases and healthcare costs.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Of the estimated 1.2 million Americans living with HIV, approximately 30%–40% are considered overweight or obese. 3…”

Section: Introductionmentioning

confidence: 99%

Virologic outcomes of antiretroviral therapy in patients with HIV-1 following bariatric surgery: A case series and review of the literature

Badowski,

Kassem,

Labedz

et al. 2023

Int J STD AIDS

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Background Selection of an antiretroviral regimen for people living with HIV (PLWH) involves various clinical considerations, such as comorbidities, archived drug resistance mutations, concomitant medications, and potential drug interactions and side effects. Alterations in the surface area and pH of the gastrointestinal tract following bariatric surgery may alter absorption, antiretroviral pharmacokinetics and viral suppression. Data on the efficacy of antiretroviral (ARV) therapy in PLWH who have undergone bariatric surgery are limited or lacking for new antiretrovirals, such as dolutegravir and bictegravir. Methods This case series reports virologic outcomes and side effects in eight cases of PLWH receiving ARV therapy who underwent bariatric surgery. A systematic literature review was performed to review the available literature on the efficacy and safety of antiretroviral regimens in PLWH who have undergone bariatric surgery. Results Virologic suppression was not impacted for obese PLWH who underwent bariatric surgery following failure of life-style modifications and pharmacological therapy. Conclusions There were no deleterious effects on HIV progression for PLWH that underwent bariatric surgery. More prospective research is required to validate the effects of bariatric surgery on immunologic and virologic function outcomes. Close involvement of HIV and surgical specialists is recommended to manage ARV therapy in patients undergoing bariatric surgery.

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Long-term virologic outcomes following bariatric surgery in patients with HIV

Cited by 14 publications

References 10 publications

Antiretroviral considerations in HIV-infected patients undergoing bariatric surgery

Antiretroviral considerations in HIV-infected patients undergoing bariatric surgery

Bariatric surgery in HIV-infected patients: review of literature

Virologic outcomes of antiretroviral therapy in patients with HIV-1 following bariatric surgery: A case series and review of the literature

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