Long-term Weight Regain after Gastric Bypass: A 5-year Prospective Study

Magro, Daniéla Oliveira; Geloneze, Bruno; Delfini, Regis; Pareja, Bruna Contini; Callejas, Francisco Javier; Pareja, José Carlos

doi:10.1007/s11695-007-9265-1

Cited by 585 publications

(357 citation statements)

References 16 publications

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“…6 In fact, patients with a lower postoperative gut hormone response were demonstrated to achieve a lower BW loss after gastric bypass compared with patients with a more potent postprandial response of PYY and GLP-1. 6 Patients with poor BW loss or significant BW regain after surgery 28,29 are currently left with limited therapeutic options. Surgical revision, including reduction of pouch size or lengthening of the Roux limb, 30 is frequently used despite the lack of supporting evidence in the literature.…”

Section: Time [H] Food Intake [G]mentioning

confidence: 99%

Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass

et al. 2011

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Background: Patients show an elevated postprandial satiety gut hormone release after Roux-en-Y Gastric bypass (gastric bypass). The altered gut hormone response appears to have a prominent role in the reduction of appetite and body weight (BW) after gastric bypass. Patients with insufficient BW loss after gastric bypass have an attenuated postprandial gut hormone response in comparison with patients who lost an adequate amount of BW. The effects of additional gut hormone administration after gastric bypass are unknown. Methods: The effects of peripheral administration of peptide YY3-36 (PYY3-36; 300 nmol kg À1 ), glucagon-like peptide-1 (GLP-1) analogue Exendin-4 (20 nmol kg À1 ) and somatostatin analogue octreotide (10 mg kg À1 ) on feeding and BW were evaluated in rats after gastric bypass. Results: Gastric bypass rats weighed (Po0.01) and ate less on postoperative day 5 (Po0.001) and thereafter, whereas postprandial plasma PYY and GLP-1 levels were higher compared with sham-operated controls (Po0.001). Administration of both PYY3-36 and Exendin-4 led to a further decrease in food intake in bypass rats compared with saline treatment (P ¼ 0.02 and Po0.0001, respectively). Similar reduction in food intake was observed in sham rats (P ¼ 0.02 and Po0.001, respectively). Exendin-4 treatment resulted in a significant BW loss in bypass (P ¼ 0.03) and sham rats (P ¼ 0.04). Subsequent treatment with octreotide led to an increase in food intake in bypass (P ¼ 0.007), but not in sham rats (P ¼ 0.87). Conclusion: Peripheral administration of PYY3-36 and Exendin-4 reduces short-term food intake, whereas octreotide increases short-term food intake in rats after gastric bypass. The endogenous gut hormone response after gastric bypass can thus potentially be further enhanced by additional exogenous therapy with pharmacological doses of gut hormones in patients with insufficient weight loss or weight regain after surgery.

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Section: Time [H] Food Intake [G]mentioning

confidence: 99%

Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass

et al. 2011

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“…However, there is increasing evidence of weight regain in patients after bariatric surgery 2,3 , generally occurring between 12 and 24 months post-operatively 2,4 . Weight regain increases the risk of physical function decline which negatively affects an individual's ability to undertake activities of daily living 5 .…”

Section: Introductionmentioning

confidence: 99%

The effects of supervised exercise training 12–24 months after bariatric surgery on physical function and body composition: a randomised controlled trial

et al. 2017

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“…Twenty to 50% of the patients operated are unable to achieve the desired weight loss or present a weight increase a few years after the surgery (Benotti, 1995;Magro et al, 2008). These statistics reinforce the need to investigate factors associated with these therapeutic failures.…”

Section: Artigosmentioning

confidence: 99%

Surgical treatment of obesity: some considerations on the transformations of the eating impulse

Júnior¹,

Chaim²,

Turato³

2010

Rev. latinoam. psicopatol. fundam.

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Long-term Weight Regain after Gastric Bypass: A 5-year Prospective Study

Cited by 585 publications

References 16 publications

Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass

Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass

The effects of supervised exercise training 12–24 months after bariatric surgery on physical function and body composition: a randomised controlled trial

Surgical treatment of obesity: some considerations on the transformations of the eating impulse

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