Long-time octreotide in an adolescent with severe haemorrhagic gastrointestinal vascular malformation

Classen, Carl Friedrich; Haffner, Dieter; Hauenstein, Christina; Wolf, Ricarda; Kyank, Ulrike

doi:10.1136/bcr.05.2011.4291

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Gastrointestinal Angiodysplasia1

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2022

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“…Also, there was no GI bleeding relapse[ 40 ]. Additionally, several case reports documented the significant improvement in patients’ hemoglobin levels and decreased hospitalizations and blood transfusions among the patients with hemorrhagic gastrointestinal vascular malformations after initiating octreotide[ 41 - 43 ].…”

Section: Gastrointestinal Angiodysplasiamentioning

confidence: 99%

Role of octreotide in small bowel bleeding

Khedr¹,

Mahmoud²,

Attallah³

et al. 2022

WJCC

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Gastrointestinal bleeding accounts for a drastic negative impact on the quality of the patients’ lives as it requires multiple diagnostic and therapeutic interventions to identify the source of the bleeding. Small bowel bleeding is the least common cause of gastrointestinal bleeding. However, it is responsible for the majority of complaints from patients with persisting or recurring bleeding where the primary source of bleeding cannot be identified despite investigation. A somatostatin analog known as octreotide is among the medical treatment modalities currently used to manage small bowel bleeding. This medication helps control symptoms of gastrointestinal bleeding by augmenting platelet aggregation, decreasing splanchnic blood flow, and antagonizing angiogenesis. In this review article, we will highlight the clinical efficacy of octreotide in small bowel bleeding and its subsequent effect on morbidity and mortality.

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Section: Gastrointestinal Angiodysplasiamentioning

confidence: 99%