Long time persistence of antibodies against Mumps in fully MMR immunized young adults: an Italian retrospective cohort study

Abstract

Protective levels of antibodies induced by the MMR vaccine have been shown to decline over time, but actually there is not a formal recommendation about the opportunity of testing immunized HCWs to investigate the persistence of anti-Mumps IgG. This study aims to evaluate the long-time immunogenicity of MMR vaccination in a sample of medical students and residents of the University of Bari who attended the Hygiene Department for the biological risk assessment (April 2014-June 2018). A strategy for the management of non-responder subjects has been experimented and described. Two thousand students and residents, with documented immunization status (two doses of MMR vaccine), have been tested. 120/2,000 (6%; 95%CI = 5.0-7.1%) subjects did not show anti-Mumps IgG. This percentage was similar among males and females. After a third MMR dose, we noted a seroconversion of 90% of seronegative participants. No serious adverse events were recorded. An important proportion of subjects immunized for MMR do not show an antibodies protective titer. The immunogenicity and the safety of the third dose seem confirmed by our data. Including the screening model described in the routine assessment of the biological risk of medical students and HCWs may be a winning strategy in preventing Mumps nosocomial infection.

Prevalence and management of rubella susceptibility in healthcare workers in Italy: A systematic review and meta-analysis

“…After exclusion of duplicate articles in the two databases, there were nine eligible studies [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] ( Table 1 ), of which eight were quantitative [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] and one was qualitative [18] . The remaining 88 studies did not match the inclusion criteria [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , ...…”

Long -term persistence of antibodies against varicella in fully immunized healthcare workers: an Italian retrospective cohort study

“…In another study, albeit of low scientific evidence, a period of 10 years was determined [8]. For other live-attenuated virus vaccines, such as the MMR (measles, mumps, rubella) vaccine, the duration of circulating antibodies is more than double that of the varicella vaccine [21,24,25]. A loss of circulating antibodies over time was also shown in this study by the multivariate regression models, in which the interval between the last vaccine dose and the serological assessment was identified as a determinant of serosensitivity.…”

Seroprevalence for vaccine-preventable diseases among Italian healthcare workers

“…15 Recent Italian studies evaluated the long-term immunogenicity of vaccination for HBV, measles, mumps and rubella; the administration of booster dose in operators lacking serological protection was found to be effective in increasing the rate of protection and evidencing the immunological memory of those individuals. [39][40][41][42] Health professionals' knowledge and attitudes about vaccines are a recognized determinant of their intention to recommend the vaccine to their patients and of their own vaccine acceptance: 43,44 although HCWs should generally be strong supporters of vaccination, some of them could be categorized as vaccine-hesitant. 45 Serological screening for antibody titer assessment is recommended for susceptible HCWs exposed to the risk of vaccine-preventable diseases.…”