Long-Time Trend of Colorectal Cancer Mortality Attributable to High Processed Meat Intake in China and a Bayesian Projection from 2020 to 2030: A Model-Based Study

Chen, Fangyao; Chen, Shiyu; Luo, Yaqi; Si, Aima; Yang, Yuhui; Li, Yemian; Hu, Weiwei; Zhang, Yuxiang

doi:10.3390/ijerph191710603

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…The study found that red meat consumption was associated with an increased risk of mortality from multiple hematological and solid cancers; an increase of 100 g of red meat per day was associated with an 11%-51% increase in the risk of multiple cancers, while an increase of 50 g per day of processed meat consumption was associated with an 8%-72% increase in cancers 33 . From 1990 to 2019, an increase in colorectal cancer mortality due to a high intake of processed meat was observed for both sexes in China; thus, gradually reducing the intake of processed meat may be an effective way to reduce colorectal cancer mortality 34 . We found that the current cancer risk corresponding to Chinese men's and women's BMI was within the controllable range.…”

Section: Discussionmentioning

confidence: 99%

Cancer trends and risk factors in China over the past 30 years (1990-2019)

Wu¹,

Zhang²,

Jin³

et al. 2023

J. Cancer

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Objective: We retrospectively studied cancer mortality and incidence in China from 1990 to 2019, investigated the cancer trends and risk factors, and analyzed the effects of Gross Domestic Product (GDP) on cancer mortality and incidence. Methods: Data was obtained in "Our world in data" in October 2022 to explore mortality rates of different cancers and their trends and the roles of cancer risk factors, including GDP, air pollution, etc. Results: Over the past 30 years, cancer had been China's second leading cause of death. Tracheal, bronchial, and lung cancers, with an annual growth rate of 6.5%, were the most frequently diagnosed cancers. The burden of different cancers changed as the mortality rate of cancer changed. The age-standardized cancer mortality rate had decreased by 19.0%; cancer deaths in all age groups had increased. While the number of cancer deaths in the elderly aged ≥70 did not increase distinctively, its percentage increased by 52.1% and 1.7% annually. The percentage of patients with new-onset cancer increased by 240% and 8.6% annually. For every USD 1,000 increase in GDP, cancer deaths decreased by 2.3/100,000. Tobacco, meat, and alcohol consumption and BMI had increased and were not conducive to the future control of cancer. Conclusions: We summarized the incidence and mortality of major cancers and their trends in China over the past 30 years and analyzed the effects of GDP and the roles of cancer risk factors. Overall GDP growth and effective control of air pollution reduced cancer mortality, while population aging, smoking, alcohol consumption, BMI increasing, and meat consumption brought challenges for cancer control.

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Section: Discussionmentioning

confidence: 99%

Cancer trends and risk factors in China over the past 30 years (1990-2019)

Wu¹,

Zhang²,

Jin³

et al. 2023

J. Cancer

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“…Several risk factors for CRC have been found, including inherited genetic variants such as Lynch syndrome and familial adenomatous polyposis, a personal history of IBD, and family history of CRC. Additionally, lack of physical exercise, diet rich in red and processed meat, scant consumption of fruits, vegetables, fiber, and alcohol and tobacco use are modifiable risk factors [ 128 ].…”

Section: Link Between Periodontitis/oral Bacteria and Colorectal Cancersmentioning

confidence: 99%

The Gum–Gut Axis: Periodontitis and the Risk of Gastrointestinal Cancers

Baima,

Ribaldone,

Romano

et al. 2023

Cancers

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Periodontitis has been linked to an increased risk of various chronic non-communicable diseases, including gastrointestinal cancers. Indeed, dysbiosis of the oral microbiome and immune-inflammatory pathways related to periodontitis may impact the pathophysiology of the gastrointestinal tract and its accessory organs through the so-called “gum–gut axis”. In addition to the hematogenous spread of periodontal pathogens and inflammatory cytokines, recent research suggests that oral pathobionts may translocate to the gastrointestinal tract through saliva, possibly impacting neoplastic processes in the gastrointestinal, liver, and pancreatic systems. The exact mechanisms by which oral pathogens contribute to the development of digestive tract cancers are not fully understood but may involve dysbiosis of the gut microbiome, chronic inflammation, and immune modulation/evasion, mainly through the interaction with T-helper and monocytic cells. Specifically, keystone periodontal pathogens, including Porphyromonas gingivalis and Fusobacterium nucleatum, are known to interact with the molecular hallmarks of gastrointestinal cancers, inducing genomic mutations, and promote a permissive immune microenvironment by impairing anti-tumor checkpoints. The evidence gathered here suggests a possible role of periodontitis and oral dysbiosis in the carcinogenesis of the enteral tract. The “gum–gut axis” may therefore represent a promising target for the development of strategies for the prevention and treatment of gastrointestinal cancers.

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“…Colorectal cancer (CRC) is the third most common cancer around the world and it causes the second most cancer-related deaths [1]. Currently, in China, the proportion of elderly patients is increasing and more and more extremely elderly patients are being encountered in routine clinical practice [2]. For patients with colorectal cancer, laparoscopic surgery could result in faster recovery and shorter hospital stay [3,4].…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic surgery for extremely elderly patients (≥85)-experience from a single center

Wang

Zou

et al. 2023

Preprint

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Background: More and more extremely elderly patients (≥85) with colorectal cancer are being encountered in routine clinical practice. For these patients, the laparoscopic approach has been considered as a less invasive alternative. Whereas, it is not so easy for us to accomplish controlled clinical trials among extremely elderly patients. The present study was performed to evaluate the feasibility and safety of laparoscopic surgery for extremely elderly patients. Materials and Methods: Medical records of extremely elderly patients with colorectal cancer who had underwent curative laparoscopic or open surgery were retrospectively reviewed. The clinicopathological characteristics and surgery-related outcomes of these patients were recorded and analyzed. Results: A total of 110 extremely elderly patients had undergone curative surgery at our center, including 47 open surgeries and 63 laparoscopic surgeries. The mean operation times for open surgery and laparoscopic surgery were 199.94 (±64.17) and 195.71 (±77.85) minutes, respectively. Intraoperative blood transfusion during laparoscopic surgery (258.73±549.38 ml) was not significantly different from that for open surgery (160.64±273.05 ml) (P=0.264). In the open group, 2 patients experienced major complications. In the laparoscopic group, 4 patients experienced major complications. The laparoscopic group was not significantly different from the open group in terms of overall survival (P=0.763) and recurrence-free survival (P=0.323). Of these 110 patients, the oldest was a woman aged 100 years and 10 months who had undergone curative laparoscopic sigmoidectomy. Conclusion: For extremely elderly patients with colorectal cancer, laparoscopic surgery is feasible and safe. We report the success of laparoscopic surgery for a patient aged 100 years with sigmoid colon cancer.

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Long-Time Trend of Colorectal Cancer Mortality Attributable to High Processed Meat Intake in China and a Bayesian Projection from 2020 to 2030: A Model-Based Study

Cited by 7 publications

References 36 publications

Cancer trends and risk factors in China over the past 30 years (1990-2019)

Cancer trends and risk factors in China over the past 30 years (1990-2019)

The Gum–Gut Axis: Periodontitis and the Risk of Gastrointestinal Cancers

Laparoscopic surgery for extremely elderly patients (≥85)-experience from a single center

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