Long wavelength light reduces the negative consequences of dim light at night

Wang, Huei-Bin; Luk, Shu Hon Christopher; In, Hye; Mac, Amanda; Chae, Rim; Matynia, Anna; Harrison, Ben J.; Afshari, Sina; Block, Gene D.; Ghiani, Cristina A.; Colwell, Christopher S.

doi:10.1016/j.nbd.2022.105944

Cited by 5 publications

(2 citation statements)

References 69 publications

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“…As previously reported, mice lacking ipRGCs have significantly reduced pupil constriction compared to wild-type mice. 57 , 70 , 71 …”

Section: Resultsmentioning

confidence: 99%

Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases

Matynia,

Recio,

Myers

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose Intrinsically photosensitive retinal ganglion cells (ipRGCs) play a crucial role in non–image-forming visual functions. Given their significant loss observed in various ocular degenerative diseases at early stages, this study aimed to assess changes in both the morphology and associated behavioral functions of ipRGCs in mice between 6 (mature) and 12 (late adult) months old. The findings contribute to understanding the preservation of ipRGCs in late adults and their potential as a biomarker for early ocular degenerative diseases. Methods Female and male C57BL/6J mice were used to assess the behavioral consequences of aging to mature and old adults, including pupillary light reflex, light aversion, visual acuity, and contrast sensitivity. Immunohistochemistry on retinal wholemounts from these mice was then conducted to evaluate ipRGC dendritic morphology in the ganglion cell layer (GCL) and inner nuclear layer (INL). Results Morphological analysis showed that ipRGC dendritic field complexity was remarkably stable through 12 months old of age. Similarly, the pupillary light reflex, visual acuity, and contrast sensitivity were stable in mature and old adults. Although alterations were observed in ipRGC-independent light aversion distinct from the pupillary light reflex, aged wild-type mice continuously showed enhanced light aversion with dilation. No effect of sex was observed in any tests. Conclusions The preservation of both ipRGC morphology and function highlights the potential of ipRGC-mediated function as a valuable biomarker for ocular diseases characterized by early ipRGC loss. The consistent stability of ipRGCs in mature and old adult mice suggests that detected changes in ipRGC-mediated functions could serve as early indicators or diagnostic tools for early-onset conditions such as Alzheimer's disease, Parkinson's disease, and diabetes, where ipRGC loss has been documented.

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“…As previously reported, mice lacking ipRGCs have significantly reduced pupil constriction compared to wild-type mice. 57 , 70 , 71 …”

Section: Resultsmentioning

confidence: 99%

Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases

Matynia,

Recio,

Myers

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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View full text Add to dashboard Cite

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“…Furthermore, light therapy has widely been known as a therapy for mood disorders ( 102 , 108 , 109 ). Crucially, altering the dLAN spectrum to longer wavelengths helped alleviate the adverse effects on activity rhythms and behaviors resembling ‘autistic’ traits in autistic mouse models ( 110 ). The mutant mice, when administered melatonin daily, exhibited a reduction in excessive grooming behavior, bringing it down to levels seen in wild-type mice, and their activity rhythms showed improvement ( 101 ).…”

Section: Light Pollutionmentioning

confidence: 99%

Environmental pollution and extreme weather conditions: insights into the effect on mental health

Tota,

Karska,

Kowalski

et al. 2024

Front. Psychiatry

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Environmental pollution exposures, including air, soil, water, light, and noise pollution, are critical issues that may implicate adverse mental health outcomes. Extreme weather conditions, such as hurricanes, floods, wildfires, and droughts, may also cause long-term severe concerns. However, the knowledge about possible psychiatric disorders associated with these exposures is currently not well disseminated. In this review, we aim to summarize the current knowledge on the impact of environmental pollution and extreme weather conditions on mental health, focusing on anxiety spectrum disorders, autism spectrum disorders, schizophrenia, and depression. In air pollution studies, increased concentrations of PM2.5, NO2, and SO2 were the most strongly associated with the exacerbation of anxiety, schizophrenia, and depression symptoms. We provide an overview of the suggested underlying pathomechanisms involved. We highlight that the pathogenesis of environmental pollution-related diseases is multifactorial, including increased oxidative stress, systematic inflammation, disruption of the blood-brain barrier, and epigenetic dysregulation. Light pollution and noise pollution were correlated with an increased risk of neurodegenerative disorders, particularly Alzheimer’s disease. Moreover, the impact of soil and water pollution is discussed. Such compounds as crude oil, heavy metals, natural gas, agro-chemicals (pesticides, herbicides, and fertilizers), polycyclic or polynuclear aromatic hydrocarbons (PAH), solvents, lead (Pb), and asbestos were associated with detrimental impact on mental health. Extreme weather conditions were linked to depression and anxiety spectrum disorders, namely PTSD. Several policy recommendations and awareness campaigns should be implemented, advocating for the advancement of high-quality urbanization, the mitigation of environmental pollution, and, consequently, the enhancement of residents’ mental health.

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Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala

Li,

Lee,

Chen

et al. 2024

Neurobiology of Stress

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Long wavelength light reduces the negative consequences of dim light at night

Cited by 5 publications

References 69 publications

Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases

Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases

Environmental pollution and extreme weather conditions: insights into the effect on mental health

Blue light at night produces stress-evoked heightened aggression by enhancing brain-derived neurotrophic factor in the basolateral amygdala

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