Longer duration of asthma is significantly associated with increased RV/TLC ratio

Tiwari, Anupama; Rahman, Kazi Atiqur; Abejie, Belayneh; Jain, Vipul V.; Vempilly, Jose Joseph

doi:10.1016/j.rmed.2017.01.011

Cited by 9 publications

(2 citation statements)

References 22 publications

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“…The correlation between the difference in FeNO before and after EC and the corresponding differences in RV and TLC in the asthmatic patients means that the deterioration of the airway inflammation is significantly associated with air trapping and hyperinflation, something not observed in the control group. This is particularly interesting since these defects are not as common in asthma as in COPD and when they are observed in asthma, they are associated with longer disease duration and fixed airflow obstruction[ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

Kotoulas,

Domvri,

Tsantos

et al. 2024

World J Methodol

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BACKGROUND Electronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes. AIM To investigate ECs’ effects on respiratory system, especially in patients with respiratory diseases. METHODS We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC. RESULTS The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity (TLC), respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers' changes and respiratory mechanics. CONCLUSION This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.

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Section: Discussionmentioning

confidence: 99%

Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

Kotoulas,

Domvri,

Tsantos

et al. 2024

World J Methodol

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“…Air trapping can be quantified by the ratio of residual volume (RV) to total lung capacity (TLC) (7). Several studies have found the clinical significance of the RV/TLC ratio in managing chronic respiratory diseases (8)(9)(10). The RV/TLC ratio is also known as a predictive index for various adverse outcomes of COPD, such as a decline in lung function and increased mortality (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Air Trapping and the Risk of COPD Exacerbation: Analysis From Prospective KOCOSS Cohort

Kim

Rhee

et al. 2022

Front. Med.

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Background and AimsAir trapping is a predictive index for a decline in lung function and mortality in patients with chronic obstructive pulmonary disease (COPD). However, the role of air trapping in COPD exacerbation has rarely been studied. Therefore, this study aimed to investigate the impact of air trapping as a continuous parameter on COPD exacerbation.Materials and MethodsTo evaluate air trapping, we identified the ratio of residual volume (RV) to total lung capacity (TLC) of patients with COPD from the Korean COPD Subgroup Study (KOCOSS) cohort, which is a multicenter-based, prospective, consecutive cohort in Korea. The primary outcome was a development of COPD exacerbation during 3 years of follow-up.ResultsOf 2,181 participants, 902 patients measured the RV/TLC ratio in the baseline enrollment, and 410 were evaluated for assessing the development of COPD exacerbation. Of 410 patients, the rate of moderate to severe exacerbation and severe exacerbation was 70.7% and 25.9%. A 10% increase of RV/TLC ratio increased the risk of the moderate to severe exacerbation by 35% and severe exacerbation by 36%. In subgroup analysis, an interaction effect between triple inhaled therapy and the RV/TLC ratio for severe exacerbation nullified the association between the RV/TLC ratio and severe exacerbation (p for interaction = 0.002).ConclusionsIn this prospective cohort study, we found that air trapping (representing RV/TLC ratio as a continuous parameter) showed an association with an increased risk of COPD exacerbation, particularly in patients who have not undergone triple inhaler therapy.

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Obstructive Airway Diseases

Saha,

Majumdar,

Bhattacharyya

2023

Pulmonomics: Omics Approaches for Understanding Pulmonary Diseases

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Longer duration of asthma is significantly associated with increased RV/TLC ratio

Abstract: RV/TLC ratio may be a better indicator than FEV1/FVC ratio to detect airway obstruction related to longer duration of asthma. Lung volume measurements should be done in addition to spirometry to detect changes related to airway obstruction in patients with longer duration of asthma.

Cited by 9 publications

References 22 publications

Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

Air Trapping and the Risk of COPD Exacerbation: Analysis From Prospective KOCOSS Cohort

Obstructive Airway Diseases

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