Longer Duration of Untreated Psychosis Hinders Improvement in Treatment of Chronic Schizophrenia: Community Based Early Intervention is an Evidence Based Option

Tabo, Abdulkadi̇r; Aydın, Erkan; Yumrukçal, Hüseyin; Yiğit, Sadık; Uzun, U.; Karamustafalıoğlu, Oğuz

doi:10.1007/s10597-017-0088-9

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…To summarize, our results underline the necessity of offering community-based psychosocial treatments beside antipsychotic pharmacological treatments ( 33 , 67 ). Community-based psychosocial treatments supporting the richness of interpersonal network and social support is a crucial part of the complex therapy of schizophrenia.…”

Section: Discussionmentioning

confidence: 69%

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

et al. 2018

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Schizophrenic patients have serious impairments in social cognition, which often persists after significant reduction in clinical symptoms. Community-based psychosocial treatments aim to recover social functioning for mentally ill individuals. Our aim was to examine prospective changes in social cognition and functional outcomes in two groups of schizophrenic patients involved in two forms of community-based psychosocial treatments namely case management (CM) and community-based club (CC) compared to a matched, treatment as usual (TAU) group of patients. We hypothesized that CC and CM groups would exhibit better functional and social cognitive outcomes after a 6-month long psychosocial treatment period. Seventy-five patients participated either in CC, CM or TAU. Both CC and CM took part in community-based psychosocial treatment programs including trainings, such as communication and assertiveness trainings. In addition, CC provided group therapeutic treatments and a continuously available day care where patients had the possibility to participate in various social interactions. All participants were in remission, and on maintenance antipsychotic treatment. Participants were assessed on all study variables at two time points: baseline and after 6 months with a battery of questionnaires that examined affective face perception, affective prosody perception, pragmatic language comprehension and ToM. Our results showed that functional outcomes improved significantly in the CC as well as in the CM groups, in contrast to the TAU group. While analyzing summary scores of social cognition, it was found that only the CC group increased its performance in social cognition. In addition, a significant between-group difference in social cognitive function was found after 6 months between the three groups, with the CC group performing best. When investigating associations between changes in social cognition and changes in functional outcomes during a 6-month long treatment period, we found significant correlations between the two variables both in the CC and in the CM groups. Based on our results, we suggest that a rich interpersonal network and social support have highly beneficial effects on social cognition and we would like to emphasize the necessity of offering community-based psychosocial treatments beside antipsychotic medications as early as possible as a crucial part of the complex therapy of schizophrenia.

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Section: Discussionmentioning

confidence: 69%

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

et al. 2018

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“…In the present study, we found that DUP was positively correlated with the PANSS negative scale, and longer DUP with severe negative symptoms in schizophrenic patients treated for more than 2 years. Kanahara et al identified that DUP was associated with greater negative symptoms and decreased functioning, but not with positive symptoms ( 27 ), at the same time, several studies also demonstrated that longer DUP hindered the improvement in PANSS negative, general subscales and total score in chronic SCZ ( 30 – 32 ). These findings also supported our results, especially showing increases in negative symptoms.…”

Section: Discussionmentioning

confidence: 98%

Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia

Tan²,

Wang³

et al. 2023

Front. Psychiatry

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ObjectiveTo explore the relationship between the Duration of Untreated Psychosis (DUP) and long-term clinical outcome, cognitive and social function in patients with chronic schizophrenia (SCZ).MethodsA total of 248 subjects with chronic SCZ were enrolled in this study, including 156 in the short DUP group and 92 in the long DUP group. The Positive and Negative Symptoms Scale (PANSS), the Brief Negative Symptoms Scale (BNSS), the Global Assessment of Functioning (GAF) scale and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess all of the subjects.ResultsThe negative symptom scores (the PANSS and BNSS) of subjects with long DUP were significantly higher than that in subjects with short DUP. The scores of visual span and speech function in the short DUP group were significantly higher, indicative of decreasing cognitive function with time. In terms of social function, the short DUP group scored higher, with a statistically significant difference. Meanwhile, we found that the length of DUP was positively correlated with the negative symptom score of the PANSS, negatively correlated with visual span scores, and GAF scores.ConclusionThis study demonstrated that the DUP remained a significant association with negative symptom and cognition in long period of chronic SCZ.

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“…The questionnaire was distributed via Questionnaire Star. The inclusion criteria for individuals were as follows: (1) aged ≥ 18 years; (2) diagnosed by two or more psychiatrists and meeting the diagnostic criteria for schizophrenia in the United States Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) [ 39 ]; (3) evaluated by psychiatrists and found to be currently in the remission stage of the disease, with a total score on the positive and negative symptom scales of less than 60 points, and considered in a stable condition and able to cooperate with the study; (4) individuals with normal cognitive function; and (5) voluntarily signed the informed consent form. The exclusion criteria were as follows: (1) other mental or neurological disorders, developmental disorders of the brain or severe trauma, or physical diseases; and (2) a history of drug or alcohol dependence.…”

Section: Methodsmentioning

confidence: 99%

The relationship between sleep disturbance and aggressive behaviour among community-dwelling schizophrenia patients: a moderated mesomeric effect model

Ye,

Wu,

Yue

et al. 2024

BMC Public Health

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Objective Sleep disturbance is the most common concern of patients with schizophrenia and can lead to a poor prognosis, a low survival rate and aggressive behaviour, posing a significant threat to social security and stability. The aim of this study was to explore the mediating role of depression in the relationship between sleep disturbance and aggressive behaviour in people with schizophrenia living in the community, as well as the regulatory role of family intimacy and adaptability. These findings, in turn, may provide a theoretical basis and constructive suggestions for addressing the physical and mental health problems of these patients. Method From September 2020 to August 2021, a convenience sampling method was used to select schizophrenia patients from the community attending follow-up appointments at the Fourth People’s Hospital of Pengzhou City, China. The researchers conducted a survey in the form of a star questionnaire. The survey included questions about general demographic data and disease-related questionnaires: the Pittsburgh Sleep Quality Index (PSQI), the revised Chinese version of the Modified Over Aggression Scale (MOAS), the Self-Rating Depression Scale (SDS), and the Family Adaptability and Cohesion Scale, Second Edition. FACES-II and SPSS 21.0 were used to organize and analyse the data. Results A total of 818 schizophrenia patients living in the community participated in the survey, and 785 valid questionnaires were ultimately collected, for a response rate of 95.97%. The results of multivariate analysis indicated that sex, number of psychiatric medications used, outpatient follow-up, history of hospitalization for mental disorders and sleep disturbances were factors influencing aggressive behaviour. Depression played a partial mediating role between sleep disturbance and aggressive behaviour, and the indirect effect size was 0.043 (57.33% of the total). In addition to sleep disturbance, family intimacy (β=-0.009, P < 0.01) and adaptability (β=-0.145, P < 0.001) can significantly predict depression. Conclusion The findings indicate that sleep disturbance in schizophrenia patients in the community is a risk factor for aggressive behaviour, and depression plays a partial mediating role in the relationship among sleep disturbance, aggressive behaviour and family intimacy. In addition, adaptability plays a regulatory role in the relationship between depression and sleep disturbance.

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Longer Duration of Untreated Psychosis Hinders Improvement in Treatment of Chronic Schizophrenia: Community Based Early Intervention is an Evidence Based Option

Cited by 6 publications

References 25 publications

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia

The relationship between sleep disturbance and aggressive behaviour among community-dwelling schizophrenia patients: a moderated mesomeric effect model

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