Longer-Term Fourth Ventricular 5-Thioglucose Infusion Increases Body Fat in the Rat

He, Baorong; Bd, White; Gl, Edwards; Rj, Martin

doi:10.3181/00379727-217-44219

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Although acute effects of glucose on metabolic rate are well-documented, to our knowledge only three studies, one published (He et al, 1998) and two unpublished from our laboratory, have addressed if reduced glucose signaling leads to long-term increases in adiposity. The published study (He et al, 1998) examined the effect of infusing 5-thioglucose (5-TG) into the fourth ventricle of rats for 14 days.…”

Section: How Do Low Carbohydrate Diets Promote Obesity?mentioning

confidence: 99%

“…The published study (He et al, 1998) examined the effect of infusing 5-thioglucose (5-TG) into the fourth ventricle of rats for 14 days. When acutely infused into the fourth ventricle or brainstem, 5-TG produces local glucopenia leading to acute hyperphagia and other neuroendocrine responses similar those produced by 2-DG or hypoglycemia (R. C. Ritter et al, 1981;.…”

Section: How Do Low Carbohydrate Diets Promote Obesity?mentioning

confidence: 99%

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Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: A metabolic mechanism resolving the paradox

Mobbs¹,

Mastaitis²,

Yen³

et al. 2007

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High-fat diets produce obesity in part because, per calorie, glucose produces greater post-prandial thermogenesis than lipids, an effect probably mediated by glucose-sensing neurons. A very low carbohydrate/high-fat/high-protein Atkins-type diet produces obesity but is marginally ketogenic in mice. In contrast, high-sucrose/low-fat diets, and very low carbohydrate/high-fat/low-protein (antiepileptic) ketogenic diets reverse diet-induced obesity independent of caloric intake. We propose that a non-ketogenic high-fat diet reduces glucose metabolism and signaling in glucose-sensing neurons, thereby reducing postprandial thermogenesis, and that a ketogenic high-fat diet does not reduce glucose signaling, thereby preventing and/or reversing obesity. Keywords obesity; low-carbohydrate diets; high-fat diets; ketogenic diets Do low carbohydrate diets promote or reverse obesity?"A systematic review of low-carbohydrate diets found that the weight loss achieved is associated with the duration of the diet and restriction of energy intake, but not with restriction of carbohydrates." (Astrup et al., 2004) "This review covers evidence from carefully controlled laboratory studies, clinical trials, studies in populations at high risk of developing obesity, and epidemiologic studies on the role of sugars, particularly sucrose, in the development of obesity. Although many environmental factors promote a positive energy balance, it is clear that the consumption of a lowcarbohydrate, high-fat diet increases the likelihood of weight gain." (Saris, 2003) These two statements from recent reviews neatly state the current consensus regarding the effect of dietary composition on obesity. In fact, despite the enormous popularity of lowcarbohydrate diets such as the Atkins diet, the South Beach diet and the Zone diet, the professional consensus is that low-carbohydrate diets (which typically implies high-fat diets) are more likely to produce obesity than reverse obesity. Although several studies have reported that low-carbohydrate diets are slightly better than low-fat diets to reduce body weight over a

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Section: How Do Low Carbohydrate Diets Promote Obesity?mentioning

confidence: 99%

Section: How Do Low Carbohydrate Diets Promote Obesity?mentioning

confidence: 99%