Longevity and Efficacy of Bifenthrin Treatment on Desert-Pattern US Military Camouflage Netting Against Mosquitoes in a Hot-Arid Environment

Britch, Seth C.; Linthicum, Kenneth J.; Wynn, W. Wayne; Aldridge, Robert L.; Walker, Todd W.; Farooq, Muhammad; Dunford, James C.; Smith, Vincent L.; Robinson, C. A.; Lothrop, Branka B.; Snelling, M. J.; Gutierrez, Arturo; Wittie, Jeremy; White, Gregory S.

doi:10.2987/11-6134.1

Cited by 16 publications

(19 citation statements)

References 8 publications

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“…Synthetic pyrethroids (SPs), a group of universal pesticides commonly applied to control field and household pests, have seen an increase in use after many governments issued restrictions on organophosphate and carbamate insecticides . The sale of SPs accounted for about 17% of the world insecticide market in 2007 .…”

Section: Introductionmentioning

confidence: 99%

Cis -bifenthrin induces immunotoxicity in adolescent male C57BL/6 mice

Wang

Gao

et al. 2017

Environmental Toxicology

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Bifenthrin (BF) is an important synthetic pyrethroid. Previous studies have demonstrated that cis-BF exhibits toxic effects on development, the neurological, reproductive and endocrine system. In this study, we evaluated the immunotoxicity caused by cis-BF in adolescent male C57BL/6 mice. Mice were exposed orally to 0, 5, 10, and 20 mg/kg/d for 3 weeks. The results showed that body weight, spleen weight, and splenic cellularity decreased in mice exposed to 20 mg/kg/d cis-BF. Additionally, we found that the mRNA levels of the pro-inflammatory factors IL-1β, IL-6, CXCL-1, and TNF-α, in peritoneal macrophages, the spleen, and the thymus were inhibited in the cis-BF-treated groups. Moreover, MTT assays demonstrated that cis-BF inhibited splenocyte proliferation stimulated by LPS or Con A, as well as the secretion of IFN-γ on Con A stimulation. Collectively, the results of this study suggest that exposure to cis-BF has the potential to induce immunotoxicity in adolescent male C57BL/6 mice.

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Section: Introductionmentioning

confidence: 99%

Cis -bifenthrin induces immunotoxicity in adolescent male C57BL/6 mice

Wang

Gao

et al. 2017

Environmental Toxicology

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“…In hot desert environments, angle the cages on the poles such that the insects are not in direct sunlight and may move into the shade of the side of the cage cylinder. 4. In both treatment and control areas, clearly label each sentinel cage with a permanent marker as it is put in place with two pieces of information: (1) the pole and/or box unique position code for later mapping in the GIS, and (2) pre-spray mortality for later correction for spray-induced mortality or mortality from exposure to the environment regardless of spray.…”

Section: Deploying the Sentinel Cagesmentioning

confidence: 99%

Visualizing Efficacy of Pesticides Against Disease Vector Mosquitoes in the Field

Britch

Linthicum

Aldridge

et al. 2019

JoVE

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Efficacy of public health pesticides targeting nuisance and disease-vector insects such as mosquitoes, sand flies, and filth-breeding flies is not uniform across ecological zones. To best protect public and veterinary health from these insects, the environmental limitations of pesticides need to be investigated to inform effective use of the most appropriate pesticide formulations and techniques. We have developed a research program to evaluate combinations of pesticides, pesticide application equipment, and application techniques in hot-arid desert, hot-humid tropical, warm and cool temperate, and urban locations to derive pesticide use guidelines specific to target insect and environment. To these ends we designed a system of protocols to support efficient, cost-effective, portable, and standardized evaluation of a diverse range of pesticides and equipment across multiple environments. At the core of these protocols is the use of an array of small cages with colony-reared sentinel mosquitoes (adults and immatures) and sand flies (adults), strategically arranged in natural habitats and exposed to pesticide spray. Spatial and temporal patterns of pesticide efficacy are derived from percent mortality in sentinel cages, then mapped and visualized in a geographic information system. Maps of sentinel mortality data may be statistically compared to evaluate relative efficacy of a pesticide across multiple environments, or to study multiple pesticides in a single environment. Protocols may be modified to accommodate a variety of scenarios, including, for example, the vertical orientation of sentinels in canopy habitats or simultaneous testing of ground and aerial application methods.

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“…Pyrethroids were registered for use in a wide variety of agricultural and nonagricultural applications. Bifenthrin (2‐methylbiphenyl‐3‐ylmethyl‐(Z)‐(1RS)‐cis‐3‐(2‐chloro‐3, 3, 3‐trifluoroprop‐1‐enyl)‐2, 2‐dimethylcyclopropane carboxylate, BF), one of the most common pyrethroids, is widely used to control field and household pests (Suwannayod et al, ; Britch et al, ). As a result, humans may have suffered from potential exposure to this compound (Shafer et al, ).…”

Section: Introductionmentioning

confidence: 99%

Enantioselective disruption of the endocrine system by Cis‐Bifenthrin in the male mice

Jin

Wang

Pan

et al. 2014

Environmental Toxicology

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Bifenthrin (BF), as a chiral pyrethroid, is widely used to control field and household pests in China. At present, the commercial BF is a mixed compound containing cis isomers (cis-BF) including two enantiomers of 1R-cis-BF and 1S-cis-BF. In the present study, the two individual cis-BF enantiomers were separated by a preparative supercritical fluid chromatography. Then, four week-old adolescent male ICR mice were orally administered 1R-cis-BF and 1S-cis-BF separately daily for 3 weeks at doses of 0, 7.5 and 15 mg/kg/day, respectively. Results showed that the transcription status of some genes involved in cholesterol synthesis and transport as well as testosterone (T) synthesis in the testes were influenced by cis-BF enantiomers. Especially, we observed that the transcription status of key genes on the pathway of T synthesis including cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc) and cytochrome P450 17α-hydroxysteroid dehydrogenase (P45017α)) were selectively altered in the testis of mice when treated with 1S-cis-BF, suggesting that it is the possible reason to explain why the lower serum T concentration in 1S-cis-BF treated group. Taken together, it concluded that both of the cis-BF enantiomers have the endocrine disruption activities, while 1S-cis-BF was higher than 1R-cis-BF in mice when exposed during the puberty. The data was helpful to understand the toxicity of cis-BF in mammals under enantiomeric level.

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Longevity and Efficacy of Bifenthrin Treatment on Desert-Pattern US Military Camouflage Netting Against Mosquitoes in a Hot-Arid Environment

Cited by 16 publications

References 8 publications

Cis -bifenthrin induces immunotoxicity in adolescent male C57BL/6 mice

Cis -bifenthrin induces immunotoxicity in adolescent male C57BL/6 mice

Visualizing Efficacy of Pesticides Against Disease Vector Mosquitoes in the Field

Enantioselective disruption of the endocrine system by Cis‐Bifenthrin in the male mice

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