Longevity and Its Regulation: Centenarians and Beyond

Robert, L.; Fülöp, Tamás

doi:10.1159/000358907

Cited by 9 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, there is a possibility that future efforts will enable people to live longer (Christensen, et al, 2009), perhaps even much longer, so that the age of 102 years may not represent the true “final stage” of human longevity. Whereas this theoretically may be true, we note that, as of November 2014, in the entire world, there were only estimated to be 300–450 individuals over the age of 110 (only 79 validated at that time; see (Robert and Fulop, 2014) and http://www.grg.org/Adams/E.HTM), out of >7,000,000,000 alive, so the potential for widespread lifespan attainment much beyond that is theoretical indeed.…”

Section: Discussionmentioning

confidence: 86%

Brain pathologies in extreme old age

Neltner

Abner

Jicha

et al. 2016

Neurobiology of Aging

View full text Add to dashboard Cite

With an emphasis on evolving concepts in the field, we evaluated neuropathologic data from very old research volunteers whose brain autopsies were performed at University of Kentucky (UK-ADC), incorporating data from the Georgia Centenarian Study (N=49 cases included), the Nun Study (N=17), and UK-ADC (N=11) cohorts. Average age of death was 102.0 years (range: 98–107) overall. Alzheimer’s disease (AD) pathology was not universal (62% with “moderate” or “frequent” neuritic amyloid plaque densities) whereas frontotemporal lobar degeneration (FTLD) was absent. By contrast, some hippocampal neurofibrillary tangles (including primary age-related tauopathy [PART]) were observed in every case. Lewy body pathology was seen in 16.9% of subjects, hippocampal sclerosis of aging (HS-Aging) in 20.8%. We describe anatomical distributions of pigment-laden macrophages, expanded Virchow-Robin spaces, and arteriolosclerosis among Georgia Centenarians. Moderate or severe arteriolosclerosis pathology, throughout the brain, was associated with both HS-Aging pathology and an ABCC9 gene variant. These results provide fresh insights into the complex cerebral multimorbidity, and a novel genetic risk factor, at the far end of the human aging spectrum.

show abstract

Section: Discussionmentioning

confidence: 86%

Brain pathologies in extreme old age

Neltner

Abner

Jicha

et al. 2016

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

“…The study of ''supercentenarians'' is also against such predictions (details in [8]). Only a fraction of centenarians, about 0.15% to a maximum of about 0.5% was reported to reach 110 years, mostly women [38]. Experimentation on this subject is difficult to conceive, first because of ethical reasons.…”

Section: The Maillard Reaction Life Limiting ''Illicite'' Organic Chmentioning

confidence: 99%

Longevity and aging. Mechanisms and perspectives

Labat‐Robert

Robert

2015

Pathologie Biologie

Self Cite

View full text Add to dashboard Cite

“…The study by Robert and Fulop found that nutritional factors play an important role in longevity, in addition, unhealthy nutrition combined with a marked sedentary life is a major cause of obesity, reaching up to 30% of our population. Obesity is a serious risk factor for many diseases (18). The diet should be rich and varied, and increase the intake of grains and fruits.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on the Health Status and Behavioral Lifestyle of Centenarians and Non-centenarians in Zhejiang Province, China—A Cross-Sectional Study

Rong

Shen

Liang

et al. 2019

Front. Public Health

View full text Add to dashboard Cite

Background: The growth rate of centenarians was unusually rapid in recent decades, ushering in an era of longevity. This study aims to explore the difference between centenarians and non-centenarians using quantitative research, and to scientifically guide residents to develop the correct lifestyle and health care ways.Methods: From October 2013 to August 2017. A cross-sectional survey was conducted on 271 centenarians and 570 non-centenarians by using a questionnaire to assess longevity and health issues which was developed for the needs of the study, who came from 29 counties and districts in 11 cities of Zhejiang province, China. Two hundred and fifty-five valid questionnaires were returned, with an effective response rate of 94.1%. Meanwhile, data of 526 non-centenarians from Zhejiang province was collected as a control group, with an effective response rate of 92.3%.Results: The prevalence rates of tumor, stomach and duodenal ulcer, diabetes, bronchial asthma, and chronic obstructive pulmonary disease, tuberculosis among centenarians were all lower than those among non-centenarians. The oral health of centenarians is better than that of non-centenarians. The consumption of coarse cereals, pasta, other staple foods and fruits among centenarians was higher than that of non-centenarians. The percentage of centenarians who smoke or engage in recreational activities every day was lower than that of non-centenarians.Conclusions: We should give full play to the role of preventive medicine and health management to safeguard the health of residents. Pay attention to oral health, and develop the good habit of loving teeth. The diet should be rich and varied, and increase the intake of grains and fruits. Give up smoking, limit alcohol, spirit-preserving with calming, follow the law of scientific regimen.

show abstract

Longevity and Its Regulation: Centenarians and Beyond

Cited by 9 publications

References 34 publications

Brain pathologies in extreme old age

Brain pathologies in extreme old age

Longevity and aging. Mechanisms and perspectives

A Comparative Study on the Health Status and Behavioral Lifestyle of Centenarians and Non-centenarians in Zhejiang Province, China—A Cross-Sectional Study

Contact Info

Product

Resources

About