Handbook of the Biology of Aging 2016
DOI: 10.1016/b978-0-12-411596-5.00001-0
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Longevity as a Complex Genetic Trait

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Cited by 5 publications
(3 citation statements)
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“…The necessity for a metrics of senescence and ageing with biomarkers goes along with the disentanglement of chronological and biological points in time. CA is disentangled from BA, a measure of the degree of age-associated decline that an individual undergoes [80‒83]. Within this scope, routine medical laboratory assays can be leveraged as part of modern high-throughput technologies for genomics, transcriptomics, proteomics, microbiomics and metabolomics, hence contributing to the integrative analysis of biological events such as senescence [84].…”
Section: Ageing Hallmarks and Biomarkersmentioning
confidence: 99%
“…The necessity for a metrics of senescence and ageing with biomarkers goes along with the disentanglement of chronological and biological points in time. CA is disentangled from BA, a measure of the degree of age-associated decline that an individual undergoes [80‒83]. Within this scope, routine medical laboratory assays can be leveraged as part of modern high-throughput technologies for genomics, transcriptomics, proteomics, microbiomics and metabolomics, hence contributing to the integrative analysis of biological events such as senescence [84].…”
Section: Ageing Hallmarks and Biomarkersmentioning
confidence: 99%
“…In contrast to humans or any mammal, these age-dependent changes occur on a compressed time-scale of days rather than years, with an average lifespan of only a few weeks. On a genetic level, orthologs of roughly half of all human genes have been identified, and tools have been developed to rapidly, easily, and inexpensively manipulate those genes in C. elegans worms, making them an ideal choice for genetic screens [15]. However, it is difficult to substantiate findings in C. elegans as relevant to human physiology without any means of contextualizing the results in mammalian systems.…”
Section: Introductionmentioning
confidence: 99%
“…Aging is acknowledged as a complex trait that is influenced by both intrinsic and extrinsic factors (Sutphin and Korstanje, 2016). Over the past two decades, hundreds of longevity genes and pathways have been identified in model organisms (Kenyon, 2010).…”
Section: Introductionmentioning
confidence: 99%