Longevity of Parasitic Worms: The Term of Living Existence of Schistosoma Hæmatobium in the Human Body.

Christopherson, J. B.

doi:10.1016/s0140-6736(01)16114-3

Cited by 10 publications

(5 citation statements)

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“…12 Bladder cancer is not uncommon with long-term infection with S. haematobium and, as in the present case, prolonged infection associated with cancer has been noted 18, 28, and 29 years after exposure. 13,14 There seemed to be a breakdown in health measures in 1974 after the end of Portuguese colonization, and many returning colonists and soldiers from Africa could have been infected with schistosomes. Relatively few returning persons were examined upon their return to Portugal, and stool and urine examinations found 3.4% positive for S. mansoni and 2.8% positive for S. haematobium.…”

Section: Discussionmentioning

confidence: 99%

“…15 Furthermore, it was reported that, during the war in South Africa, British soldiers contracted S. haematobium infections that were detected 18 years after their return to England. 13 More than 1300 soldiers acquired S. japonicum during the invasion of Leyte in the Philippines in World War II. 16 More recently, during practice training for the invasion of Taiwan, Chinese communist soldiers were exposed to S. japonicum along the Yangtze River basin.…”

Section: Discussionmentioning

confidence: 99%

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Latent Schistosomiasis in Portuguese Soldiers

Miranda

Cerqueira

Delgado³

et al. 2007

Military Medicine

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Schistosomiasis was diagnosed in two Portuguese soldiers who had been deployed to Portuguese colonies in Africa. The first veteran was diagnosed as having schistosomiasis 34 years after returning from Angola, and the second veteran was found with Schistosoma haematobium infection 40 years after returning from Mozambique. The patient with Schistosoma mansoni had an active infection, because eggs were recovered with living miracidia. The second patient had developed urothelial cancer, but eggs recovered were calcified.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Latent Schistosomiasis in Portuguese Soldiers

Miranda

Cerqueira

Delgado³

et al. 2007

Military Medicine

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“…The first injectable anti-schistosomal treatment, potassium antimony tartrate, or tartar emetic (TE), which contained trivalent antimony, was introduced in 1918 as a drug initially used to treat visceral leishmaniasis (Christopherson, 1924) (Fig. 1).…”

Section: T H E E V O L U T I O N O F a N T I -S C H I S T O S O M A Lmentioning

confidence: 99%

“…With the increasing availability of low-cost ultrasound in endemic areas, this approach could provide a point-of-care morbidity detection tool that could allow better definition of the risk of early childhood pathology (Belard et al, 2016;Richter et al, 2016). << Please insertFigure 5here>>THE EVOLUTION OF ANTI-SCHISTOSOMAL TREATMENTThe first injectable anti-schistosomal treatment, potassium antimony tartrate, or tartar emetic (TE), which contained trivalent antimony, was introduced in 1918 as a drug initially used to treat visceral leishmaniasis (Christopherson, 1924). (Figure 1)…”

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confidence: 99%

One hundred years of neglect in paediatric schistosomiasis

et al. 2017

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Early in the history of schistosomiasis research, children under 5 years of age were known to be infected. Although this problem was recognized over 100 years ago, insufficient action has been taken to address this issue. Under current policy, such infected children only receive their first antiparasitic treatment (praziquantel - PZQ) upon entry into primary school as current mass drug administration programmes typically target school-aged children. For many infected children, they will wait up to 6 years before receiving their first medication and significant schistosomiasis-related morbidity may have already established. This inequity would not be accepted for other diseases. To unveil some of the reasons behind this neglect, it is paramount to understand the intricate historical relationship between schistosomiasis and British Imperial medicine, to underline its lasting influence on today's public health priorities. This review presents a perspective on the historical neglect of paediatric schistosomiasis, focusing on important gaps that persist from the early days after discovery of this parasite. Looking to end this inequity, we address several issues that need to be overcome to move forward towards the lasting success of schistosomiasis control and elimination efforts.

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“…Parasitic flatworms such as flukes and tapeworms live in a protected environment in their hosts, and may have even longer lifespans; records of 25 to more than 35 years have been noted (reviewed in Comfort, 1956). Christopherson (1924) reports that a scientist infected with Schistosoma flukes passed live eggs in his urine for at least 28 years (the life cycle requires an intermediate host), after which he stopped monitoring their passage; eggs were absent when checked after a total of 42 years.…”

Section: Aging In Flatworms – Longevity Depends On Asexual Fissionmentioning

confidence: 99%

Aging and longevity in the simplest animals and the quest for immortality

Petralia

Mattson

Yao

2014

Ageing Research Reviews

115

107

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Here we review the examples of great longevity and potential immortality in the earliest animal types and contrast and compare these to humans and other higher animals. We start by discussing aging in single-celled organisms such as yeast and ciliates, and the idea of the immortal cell clone. Then we describe how these cell clones could become organized into colonies of different cell types that lead to multicellular animal life. We survey aging and longevity in all of the basal metazoan groups including ctenophores (comb jellies), sponges, placozoans, cnidarians (hydras, jellyfish, corals and sea anemones) and myxozoans. Then we move to the simplest bilaterian animals (with a head, three body cell layers, and bilateral symmetry), the two phyla of flatworms. A key determinant of longevity and immortality in most of these simple animals is the large numbers of pluripotent stem cells that underlie the remarkable abilities of these animals to regenerate and rejuvenate themselves. Finally, we discuss briefly the evolution of the higher bilaterians and how longevity was reduced and immortality lost due to attainment of greater body complexity and cell cycle strategies that protect these complex organisms from developing tumors. We also briefly consider how the evolution of multiple aging-related mechanisms/pathwayshinders our ability to understand and modify the aging process in higher organisms.

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Longevity of Parasitic Worms: The Term of Living Existence of Schistosoma Hæmatobium in the Human Body.

Cited by 10 publications

References 0 publications

Latent Schistosomiasis in Portuguese Soldiers

Latent Schistosomiasis in Portuguese Soldiers

One hundred years of neglect in paediatric schistosomiasis

Aging and longevity in the simplest animals and the quest for immortality

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