Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans

Shukla, Virendra; Yadav, Deepti; Phulara, Suresh Chandra; Gupta, Madan M.; Saikia, Shilpi K.; Pandey, Rakesh

doi:10.1016/j.freeradbiomed.2012.08.594

Cited by 38 publications

(18 citation statements)

References 44 publications

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“…The increment in oxidative and thermal stress tolerance indicates lifespan extension due to stress modulation by SPC. Similar findings suggest that lifespan extension due to stress modulation has been reported previously by various researchers (Sunagawa et al, 2011;Shukla et al, The lipofuscin level was quantified by determining the average pixel intensity in each worm using Image-J software (NIH). The statistical differences between the control and treated worms were determined with the aid of the parametric t-test.…”

Section: Discussionsupporting

confidence: 85%

“…epigallocatechingallate, beta-caryophyllene, resveratrol, iridoids and polyphenols etc. has earlier been reported (Valenzano et al, 2006;Wilson et al, 2006;Zhang et al, 2009;Shukla et al, 2012;Pant et al, 2014). SPC (6-Ocoumaroylcatalpol) is an iridoid glucoside isolated from the aerial parts of S. suaveolens.…”

Section: Discussionmentioning

confidence: 99%

“…3A). There are several studies in which protective actions of flavonoids and iridoids have been attributed to their anti-aging activity in C. elegans (Valenzano et al, 2006;Shukla et al, 2012). The progression in age has been associated with decline in feeding behavior and pumping of the pharyngeal bulb is responsible for feeding in C. elegans which normally deteriorates with age.…”

Section: Discussionmentioning

confidence: 99%

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Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

Asthana

Yadav

Pant

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

Asthana

Yadav

Pant

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…The study exhibited activation of an endogenous ROS detoxification pathway and several stress-inducible genes, viz., hsp-16.2 and sod-3 by 4-HEG [101]. The nuclear localization of DAF-16 and its up regulation were responsible for the 4-HEGmediated longevity in C. elegans [101].…”

Section: -Hydroxy-e-globularininmentioning

confidence: 98%

“…This class of compound play important role in plant defence system and traditionally used in the treating hepatic dysfunction, stimulation of bile acid excretion and tumours due to its high antioxidant and antiinflammatory activities [99,100]. Recently the antiaging activity of 4-HEG has been reported in C. elegans [101]. The study exhibited activation of an endogenous ROS detoxification pathway and several stress-inducible genes, viz., hsp-16.2 and sod-3 by 4-HEG [101].…”

Section: -Hydroxy-e-globularininmentioning

confidence: 99%

Bioactive phytomolecules and aging in Caenorhabditis elegans

2015

Healthy Aging Res

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Aging is a complex phenomenon, a sum total of changes that occur in a living organism with the passage of time and leads to decreasing ability to survive stress, increasing functional impairment and growing probability of death. Aging changes can be attributed to development, genetic defects, environmental factors, disease and an innate process-the aging process. Aging has been one of the most crucial menace factors for a number of socioeconomic burdens, hence discovery of any new chemical that modulates aging in research model organisms could lead to a new strategy for working upon age related diseases like diabetes, cancer and neuro-degenerative disorders. The present review highlights the previous studies suggesting effective modulation of the life prolonging mechanistic pathways and lifespan by various phytomolecules. The free living nematode Caenorhabditis elegans is a well established multicellular model organism for aging in biological research, being used by different laboratories worldwide. The enormous characteristics of this animal model that has contributed to its success includes its genetic pliability, invariant and fully described developmental program, well characterized genome, ease of maintenance, short and fertile life cycle and small body size. Being a multicellular organism it goes through a complex developmental process, including embryogenesis, morphogenesis to grow into an adult so, any biological information from C. elegans may be directly linked with more complex organisms, such as human. The reports on life span extension on exposure to plant based compounds clearly depicts that aging can be slowed down and thus makes life span extension an interesting area for research. This review summarizes the current understanding on interaction of phytomolecules with signalling pathways of aging that provides potential application in human health improvement and development of antiaging therapeutics.

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Optimization in continuous phase‐transition extraction of crude flavonoids from finger citron fruit and evaluation on their antiaging activities

Chen

Wang

Liu

et al. 2020

Food Science & Nutrition

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The development of antiaging functional products is a hot topic in the field of functional foods. However, the efficient extraction of functional ingredients is the limiting step for the functional food industry. Continuous phase‐transition extraction (CPE) is a new extraction technique that combines the advantages of Soxhlet extraction and supercritical extraction, which may have a distinct advantage over traditional methods in the extraction of flavonoids. In our study, the Box–Behnken design combined with response surface methodology was used to optimize CPE of crude flavonoids from finger citron fruit. The antiaging activities of finger citron crude flavonoids (FCCF) were evaluated by Caenorhabditis elegans (C. elegans) model. The optimal extraction conditions for CPE were as follows: ethanol concentration 85%, temperature 90°C, time 120 min, and pressure 0.2 MPa. Compared with the heat reflux extraction, the extraction rate and content of FCCF extracted by CPE increased by 24.28% and 33.22% (p < .05), respectively. FCCF extended the lifespan of C. elegans by 14.94% without causing adverse effects on their reproduction and locomotion ability. A further analysis suggested that FCCF prolonged the lifespan of nematodes under normal and oxidative stress by increasing the activity of major enzymes in endogenous antioxidant defense system and reducing the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA). The results confirmed the effectiveness of CPE in extracting crude flavonoids from finger citron fruit, and the extracted FCCF exhibited strong antiaging activities.

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Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans

Cited by 38 publications

References 44 publications

Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans

Bioactive phytomolecules and aging in Caenorhabditis elegans

Optimization in continuous phase‐transition extraction of crude flavonoids from finger citron fruit and evaluation on their antiaging activities

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