Longistatin in tick saliva blocks advanced glycation end-product receptor activation

Anisuzzaman, Anisuzzaman; Hatta, Takeshi; Miyoshi, Takeharu; Matsubayashi, Makoto; Islam, M. Khyrul; Alim, Md. Abdul; Anas, Marwan; Hašan, Miloš; Matsumoto, Yasunobu; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Fujisaki, Kozo; Tsuji, Naotoshi

doi:10.1172/jci74917

Cited by 37 publications

(58 citation statements)

References 58 publications

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“…On the other hand, an activator of plasminogen, called longistatin from H. longicornis, was found to cause hydrolysis of fibrinogen and delay formation of the fibrin clot as comparable to that of tissue-type plasminogen activator (t-PA) [177]. The recombinant form of longistatins is able to inhibit inflammation associated to tick feeding [178].…”

Section: Components Affecting Fibrinolysismentioning

confidence: 99%

Anticoagulants from Hematophagous

Chudzinski-Tavassi¹,

Faria²,

Flores³

2018

Anticoagulant Drugs

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This chapter will focus on anticoagulant molecules described until now from hematophagous animals. The evolutionary scenario for hematophagous animals is convergent and has resulted on a wide diversity of saliva anticoagulants, substances with platelet antiaggregation action, and also with vase-dilating action. Hematophagous animals such as bloodsuckers (leeches, mosquitoes, and ticks) have developed strategies that specifically target proteinases from the hemostatic system of the animals they feed, thus keeping the blood incoagulable. The saliva of those animals provides a large amount of molecules to modulate the innate immune response of the host and to inhibit blood coagulation in order to facilitate the feeding. Thus, anticoagulants from hematophagous animals represent a very interesting tool for studies ranging from basic research to applications in the therapeutic area, as anticoagulant medication. Several studies have pointed out that anticoagulants from hematophagous can also display non-hemostatic functions as antitumor, bringing new perspectives for the study of these molecules. The comprehension of the multi-faced physiological roles of those new anticoagulants from hematophagous opens new perspectives for therapeutic and biotechnological approaches.

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Section: Components Affecting Fibrinolysismentioning

confidence: 99%

Anticoagulants from Hematophagous

Chudzinski-Tavassi¹,

Faria²,

Flores³

2018

Anticoagulant Drugs

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“…H. longicornis is easy to maintain and is widely used as a model tick to study pathophysiology in tick infestation33. To date, a number of bioactive molecules have been found in H. longicornis , and those products might be available for not only tick control but also for novel drug discovery in the veterinary and medical fields78343536. The experimental infection of ticks with pathogens is considered to be an attractive tool for studying tick-pathogen interaction56.…”

Section: Discussionmentioning

confidence: 99%

“…Our experimental model would be a powerful tool for clarifying the kinetics of the tick stage of Babesia parasites. With the rapid progress of genome-editing strategies, transgenic organisms are currently available as attractive tools to aid in molecular and cellular studies of Babesia and H. longicornis 3444. Precise study of tick- Babesia molecular interactions using our developed model will also give us concrete knowledge to develop novel strategies for controlling babesiosis.…”

Section: Discussionmentioning

confidence: 99%

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Establishment of a novel tick-Babesia experimental infection model

Maeda

Hatta

Alim

et al. 2016

Sci Rep

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Ticks are potent vectors of many deadly human and animal pathogens. Tick-borne babesiosis is a well-recognized malaria-like disease that occurs worldwide and recently has attracted increased attention as an emerging zoonosis. Although the proliferation of Babesia organisms is essential in the vectors, their detailed lifecycle with time information for migration in ticks remains unknown. A novel study model for the elucidation of the migration speed of Babesia parasites in their vector tick, Haemaphysalis longicornis, has been developed using an artificial feeding system with quantitative PCR method. The detectable DNA of Babesia parasites gradually disappeared in the tick midgut at 1 day post engorgement (DPE), and in contrary increased in other organs. The results indicated that the Babesia parasite passed the H. longicornis midgut within 24 hours post engorgement, migrated to the hemolymph, and then proliferated in the organs except the midgut. This time point may be an important curfew for Babesia parasites to migrate in the tick lumen. We also visualized the Babesia parasites in the experimentally infected ticks and in their eggs using IFAT for detecting their cytoskeletal structure, which suggested the successful tick infection and transovarial transmission of the parasite. This model will shed light on the further understanding of tick-Babesia interactions.

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“…AGEs also promote melanin synthesis [13]. Aminoguanidine [14], N-phenacylthiazolium bromide [15], pyridoxamine [16], cerivastatin [3], metformin [17], pioglitazone [17], pentoxifylline [17], longistatin [18], quercetin [19], plantamajoside [20], and N-acetyl-L-cysteine [21] have been shown to inhibit AGE formation.…”

Section: Introductionmentioning

confidence: 99%

Amino Carbonylation of Epidermal Basement Membrane Inhibits Epidermal Cell Function and Is Suppressed by Methylparaben

Morimoto

Zeng

et al. 2017

Cosmetics

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This study investigated the effect of amino carbonylation (Maillard reaction) on the function of the epidermal basement membrane (BM) by analyzing epidermal cell proliferation and keratinization and stratum corneum barrier function using a three-dimensional human epidermal BM model treated with glyceraldehyde. Intracellular ATP levels were lower in cells cultured on amino-carbonylated epidermal BM as compared to those in normal epidermal BM (control). Moreover, trans-epidermal water loss was increased by culturing on amino-carbonylated BM relative to the control; this was accompanied by downregulation of filaggrin, transglutaminase-1, and serine palmitoyltransferase 2 mRNA levels. p-Hydroxybenzoic acid methyl ester (methylparaben) abrogated the decrease in ATP production and filaggrin expression in human keratinocytes induced by amino-carbonylated collagen. Thus, amino carbonylation of the epidermal BM inhibits moisture retention, keratinization, and ceramide synthesis and disrupts the barrier function of the stratum corneum. These findings suggest that methylparaben can be an effective additive to cosmetics for improving epidermal function that is compromised by amino carbonylation.

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Longistatin in tick saliva blocks advanced glycation end-product receptor activation

Abstract: grateful to K. Kita and M. Shafiqul Islam of The University of Tokyo for helpful discussion. We thank M. Shimada and M. Kobayashi for their generous help in preparing histological sections.

Cited by 37 publications

References 58 publications

Anticoagulants from Hematophagous

Anticoagulants from Hematophagous

Establishment of a novel tick-Babesia experimental infection model

Amino Carbonylation of Epidermal Basement Membrane Inhibits Epidermal Cell Function and Is Suppressed by Methylparaben

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