Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy

Schurgers, Geert; Walter, S; Pishva, Ehsan; Gülöksüz, Sinan; Peerbooms, Odette; Incio, Laura Rodriguez; Arts, Baer; Kenis, Günter; Rutten, Bart P. F.

doi:10.1016/j.euroneuro.2022.07.183

Cited by 9 publications

(12 citation statements)

References 43 publications

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“…Responders had lower methylation rates, especially in the exon I promoter of BDNF . In addition, Schurgers et al (2022) found that the gene expression of BDNF , ERK1 , and NR3C1 , in blood samples of TRD patients, significantly increased over time during ECT treatment. For these 3 genes changes, expression levels were highly correlated with changes in DNA methylation levels for several CpG sites, including negative correlations between mRNA levels of BDNF and methylation (i.e., hypomethylation), particularly in 3 CpGs (cg15462887, cg27351358, cg23426002).…”

Section: Resultsmentioning

confidence: 96%

“…All were performed with patients with MDD ( Kolshus et al, 2017 ; Neyazi et al, 2018 ; Moschny et al, 2020a ), while six studies referred to cases of treatment-resistant depression (TRD) ( Kleimann et al, 2015 ; Gururajan et al, 2016 ; Moschny et al, 2020b ; Israel-Elgali et al, 2021 ; Sirignano et al, 2021 ; Schurgers et al, 2022 ). They were all observational studies of a cohort of patients enrolled in a clinical trial with ECT, and with the evaluation of longitudinal biomarkers.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the ECT method, brief-pulse was the most used method. The devices used were Spectrum Mecta ® 5000 ( Kolshus et al, 2017 ; Moschny et al, 2020a ), and Thymatron ® System IV ( Kleimann et al, 2015 ; Moschny et al, 2020b ; Israel-Elgali et al, 2021 ; Schurgers et al, 2022 ). Most studies reported the usage of short-acting anesthetics.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies reported the usage of short-acting anesthetics. The application of the electrical stimulus was unilateral ( Moschny et al, 2020b ) or bitemporal ( Gururajan et al, 2016 ; Schurgers et al, 2022 ). Psychiatric pharmacotherapy is presented in detail in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Six studies evaluated the relationship between DNA methylation and the effects of ECT ( Kleimann et al, 2015 , Neyazi et al, 2018 ; Moschny et al, 2020a , b ; Sirignano et al, 2021 ; Schurgers et al, 2022 ). DNA samples were extracted from peripheral blood in all studies.…”

Section: Resultsmentioning

confidence: 99%

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A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

Castro

Bicca

et al. 2023

Front. Hum. Neurosci.

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IntroductionElectroconvulsive therapy (ECT) is one of the most effective strategies for treating resistant major depression. Although the mechanism of action is not fully understood and studies are limited, epigenetics is a promising area for the development of biomarkers associated with ECT treatment response.AimWe reviewed studies available in the literature that explored the epigenetics of ECT in peripheral samples from patients with major depressive disorder (MDD).MethodsA systematic review was performed following The PRISMA guidelines. The search was performed in seven electronic databases: Scopus, Web of Science, Medline, PsycINFO, Embase, Cochrane, and Cinahl.ResultsNine studies were included. Seven assessed DNA methylation and three investigated microRNAs (miR). Overall, most studies were exploratory, with small sample sizes, and we found high heterogeneity between the study’s design, ECT protocols, molecular biology methods, and epigenetic findings. Investigated candidates with some evidence of association with ECT treatment response were BDNF, S100A10, RNF213M, TNKS, FKBP5, miR-126, miR-106a, and miR-24.ConclusionThe present findings seem to support previous preclinical research, suggesting that epigenetic mechanisms play an important role in the molecular mechanism underlying ECT effects.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

Castro

Bicca

et al. 2023

Front. Hum. Neurosci.

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Leveraging DNA methylation to predict treatment response in major depressive disorder: A critical review

Dahrendorff,

Currier,

Uddin

2024

American J of Med Genetics Pt B

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Major depressive disorder (MDD) is a debilitating and prevalent mental disorder with a high disease burden. Despite a wide array of different treatment options, many patients do not respond to initial treatment attempts. Selection of the most appropriate treatment remains a significant clinical challenge in psychiatry, highlighting the need for the development of biomarkers with predictive utility. Recently, the epigenetic modification DNA methylation (DNAm) has emerged to be of great interest as a potential predictor of MDD treatment outcomes. Here, we review efforts to date that seek to identify DNAm signatures associated with treatment response in individuals with MDD. Searches were conducted in the databases PubMed, Scopus, and Web of Science with the concepts and keywords MDD, DNAm, antidepressants, psychotherapy, cognitive behavior therapy, electroconvulsive therapy, transcranial magnetic stimulation, and brain stimulation therapies. We identified 32 studies implicating DNAm patterns associated with MDD treatment outcomes. The majority of studies (N = 25) are focused on selected target genes exploring treatment outcomes in pharmacological treatments (N = 22) with a few studies assessing treatment response to electroconvulsive therapy (N = 3). Additionally, there are few genome‐scale efforts (N = 7) to characterize DNAm patterns associated with treatment outcomes. There is a relative dearth of studies investigating DNAm patterns in relation to psychotherapy, electroconvulsive therapy, or transcranial magnetic stimulation; importantly, most existing studies have limited sample sizes. Given the heterogeneity in both methods and results of studies to date, there is a need for additional studies before existing findings can inform clinical decisions.

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5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?

Dourron,

Nichols,

Simonsson

et al. 2023

Psychopharmacology

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Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy

Cited by 9 publications

References 43 publications

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

Leveraging DNA methylation to predict treatment response in major depressive disorder: A critical review

5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?

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