2021
DOI: 10.3390/jcm10235597
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Longitudinal Analyses of the Reciprocity of Depression and Anxiety after Traumatic Brain Injury and Its Clinical Implications

Abstract: Depression and anxiety are common following traumatic brain injury (TBI). Understanding their prevalence and interplay within the first year after TBI with differing severities may improve patients’ outcomes after TBI. Individuals with a clinical diagnosis of TBI recruited for the large European collaborative longitudinal study CENTER-TBI were screened for patient-reported major depression (MD) and generalized anxiety disorder (GAD) at three, six, and twelve months post-injury (N = 1683). Data were analyzed us… Show more

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Cited by 19 publications
(16 citation statements)
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“…Conceptually, our ndings provide some preliminary evidence for generalizability of structural models of anxiety and depression symptoms to TBI as described above and therefore also add to previous research seeking to understand the complex relationship between anxiety and depression in TBI and other neurological populations [23][24][25]76,77 . Practically, our ndings argue against the status quo of scoring and interpreting the HADS subscales.…”
Section: Discussionsupporting
confidence: 59%
“…Conceptually, our ndings provide some preliminary evidence for generalizability of structural models of anxiety and depression symptoms to TBI as described above and therefore also add to previous research seeking to understand the complex relationship between anxiety and depression in TBI and other neurological populations [23][24][25]76,77 . Practically, our ndings argue against the status quo of scoring and interpreting the HADS subscales.…”
Section: Discussionsupporting
confidence: 59%
“…Depression and other psychiatric disorders are common following TBI 21 25 . Post-traumatic changes, such as neuroinflammation and neuroendocrine dysregulation are suggested to play an important role in the development of depression 26 .…”
Section: Introductionmentioning
confidence: 99%
“…At least one in five people with mTBI will experience a major depressive episode, anxiety disorder or post-traumatic stress disorder (PTSD). [3][4][5][6][7][8][9][10][11][12] This rate is higher than in the general population 13 14 and higher than the…”
Section: Introductionmentioning
confidence: 99%
“…Recovery is frequently complicated by psychiatric comorbidity. At least one in five people with mTBI will experience a major depressive episode, anxiety disorder or post-traumatic stress disorder (PTSD) 3–12. This rate is higher than in the general population13 14 and higher than the rate in people with traumatic injuries not involving the head 15.…”
Section: Introductionmentioning
confidence: 99%
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