Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia

Garcés, María Fernanda; Vallejo, Sergio; Sánchez, Elizabeth; Palomino-Palomino, Miguel A.; Leal, Luis; Angel‐Müller, Edith; Díaz-Cruz, Luz Amparo; Ruíz-Parra, Ariel Iván; Clavijo, Angélica María González; Castaño, Justo P.; Abba, Martı́n C.; Lacunza, Ezequiel; Diéguez, Carlos; Nogueiras, Rubén; Caminos, Jorge Eduardo

doi:10.1111/cen.12715

Cited by 12 publications

(5 citation statements)

References 38 publications

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“…82 Another interesting finding was the low levels of FS in EPE, in line with previous reports of lower levels in PE, and an increase with gestational age in uneventful pregnancies. 28,83 Through neutralization of the TGF-β superfamily members, FS participates in various processes like cell growth, development, and differentiation, 84 and members of the FS family are suggested involved in CVD pathophysiology outside pregnancy. 30 Biomarkers specifically dysregulated for EPE were ST2, CX3CL1, and MMP3 (all elevated) as well as MMP1 (lower).…”

Section: Discussionmentioning

confidence: 99%

Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes

et al. 2020

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Preeclampsia, a hypertensive pregnancy disorder, links to increased long-term maternal cardiovascular disease (CVD). The risk is further increased with early-onset preeclampsia (EPE) and delivery of a growth-restricted child. We hypothesized that circulating biomarkers associated with CVD risk differed between preeclampsia subtypes and controls. We compared EPE; n=37, delivery <week 34, late-onset preeclampsia (LPE); n=29, delivery ≥week 34, and normotensive controls (n=49) using Olink Proseek multiplex CVD I assay (targeting 92 biomarkers). We stratified analysis to uteroplacental spiral artery acute atherosis presence in preeclampsia patients, sharing morphological similarities with atherosclerosis. We found 47 CVD-related biomarkers differing between the groups, 42 markers between normotensive controls and EPE, 28 markers between normotensive controls and LPE, and 9 markers between EPE and LPE. Among these 9 markers, ST2 (ST2 protein), MMP (matrix metalloproteinase) 1, MMP3, and fractalkine (CX3CL1) were uniquely dysregulated in EPE. Principal component (PC) analysis of the differing markers identified 4 clusters (named PC1–PC4) that largely separated the preeclampsia and control groups as well as pregnancies with low and high circulating PlGF (placental growth factor). The combination of the single markers PlGF, ST2, MMP1, MMP3, and CX3CL1 had a high discriminatory property to differentiate between EPE and LPE. Preeclampsia with acute atherosis or with fetal growth restriction could be differentiated by Olink biomarkers as compared with preeclampsia without these features. We identified specific CVD-related biomarkers in pregnancy depending on preeclampsia subtypes and uteroplacental acute atherosis. Assessment of these pregnancy measured biomarkers’ relation to long-term cardiovascular dysfunction and hard end points is warranted.

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Section: Discussionmentioning

confidence: 99%

Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes

et al. 2020

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“…This group of non-pregnant women was included because in previous studies it has been shown that during the menstrual cycle some hormonal factors change over this period. Therefore a reference level of this factor during the follicular and luteal phase should exist, to be compared to levels in pregnant women 63 64 .…”

Section: Methodsmentioning

confidence: 99%

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Poveda

Garcés

Ruíz-Linares

et al. 2016

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Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p < 0.01) when compared with non-pregnant healthy women, but these serum levels increased again during postpartum (p < 0.001). Adipsin levels were significantly elevated in preeclamptic women in late pregnancy (P < 0.01). A significant correlation was not found between leptin and adipsin during the three periods of gestation studied in healthy pregnant and preeclamptic women. Our results suggest that adipsin may be involved in pregnancy-associated metabolic changes. Moreover, the increase of adipsin levels towards late gestation in preeclamptic women could be related to the pathophysiology of this disease.

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“…Serum samples were separated by centrifugation at 1000 g for 15 minutes and stored at −80 °C until assay. Serum triglycerides, total cholesterol, High Density Cholesterol (cHDL), Low Density Cholesterol (cLDL), Very Low Density Cholesterol (cVLDL), glucose and insulin were measured as previously described41. The Homeostasis Model Assessment-Insulin Resistance index (HOMA-IR) was calculated in all subjects as described by Matthews et al 42…”

Section: Methodsmentioning

confidence: 99%

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Sandoval-Alzate

Agudelo-Zapata

Clavijo

et al. 2016

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Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA–IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.

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Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia

Abstract: These analyses would permit the consideration that changes in FST levels during pregnancy contribute to the control of the Act A system.

Cited by 12 publications

References 38 publications

Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes

Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

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