2011
DOI: 10.1002/mrm.23281
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Longitudinal and noninvasive assessment of emphysema evolution in a murine model using proton MRI

Abstract: Ultrashort echo time (550 ms) MR imaging was implemented to track the emphysema development in mice lung challenged with elastase. Two parameters, namely, signal intensity and T 2 *, were used to monitor the disease evolution. Nine mice were imaged before and at 24 h as well as at 3 and 8 weeks after elastase instillation. Five mice instilled with saline served as controls. At week 8, the mean normalized signal intensity 6 SD was 0.89 6 0.20 for healthy controls and 0.64 6 0.10 for animals with emphysema. Simi… Show more

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Cited by 26 publications
(27 citation statements)
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“…The decrease in the mean lung qS 0 and the decrease in the 15th percentile qS 0 in patients with COPD when compared with those values in healthy control subjects is thought to reflect the emphysema-induced parenchymal loss and blood volume decrease. These decreases in qS 0 values are in accord with the findings of earlier ex vivo studies, which showed a similar reduction in lung MR signal intensity in emphysematous mice when compared with that in healthy control mice (18,27). Iwasawa et al offered a contradictory finding of significantly higher MR signal intensity in patients with COPD than in healthy subjects at end inspiration; however, this was suspected to be less reliable because of the use of an insensitive signal normalization method (28).…”
Section: Discussionsupporting
confidence: 87%
“…The decrease in the mean lung qS 0 and the decrease in the 15th percentile qS 0 in patients with COPD when compared with those values in healthy control subjects is thought to reflect the emphysema-induced parenchymal loss and blood volume decrease. These decreases in qS 0 values are in accord with the findings of earlier ex vivo studies, which showed a similar reduction in lung MR signal intensity in emphysematous mice when compared with that in healthy control mice (18,27). Iwasawa et al offered a contradictory finding of significantly higher MR signal intensity in patients with COPD than in healthy subjects at end inspiration; however, this was suspected to be less reliable because of the use of an insensitive signal normalization method (28).…”
Section: Discussionsupporting
confidence: 87%
“…81 In addition to the use of inhaled gases, there may be a role for conventional (proton) MRI in evaluation of emphysema. [82][83][84][85] Advances in MRI imaging of the lung can result in visualization of low-proton areas of emphysema in at least 50% of cases. …”
Section: Mrimentioning
confidence: 99%
“…59 Also ultrashort echo time (UTE) MRI has been used to compare normal and emphysematous lungs in mutant mice. 60 Using a similar MRI sequence, Zurek et al 61 investigated the correlations between lung histomorphological parameters (mean chord length in lung tissue) and MR parameters (signal intensity and T 2 * values) in an elastase-instilled mouse model of emphysema (Figure 17.4). The results showed an excellent agreement between MR findings and histological morphometry and indicated that proton MRI allows structural changes at alveolar level to be monitored longitudinally.…”
Section: Emphysemamentioning
confidence: 99%