Longitudinal and Secular Trends in Blood Pressure Among Women and Men in Birth Cohorts Born Between 1905 and 1977

Hopstock, Laila Arnesdatter; Bønaa, Kaare Harald; Eggen, Anne Elise; Grimsgaard, Sameline; Jacobsen, Bjarne K.; Løchen, Maja‐Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom

doi:10.1161/hypertensionaha.115.05925

Cited by 46 publications

(41 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results suggested that there was an increase in awareness, treatment and control of hypertension from 1988 to 2010 [32]. Our results showing a decrease in both SBP and DBP in the untreated group are consistent with the findings from the Tromsø study, which showed a trend of BP reduction in the entire population, suggesting a whole population change potentially related to factors other than treatment [31]. …”

Section: Discussionsupporting

confidence: 87%

“…In the Tromso study, SBP in middle age decreased by 10.6 mmHg in women and 4.5 mmHg in men between 1979 and 2008. They suggested that this was mainly due to improved life style factors such as a reduction in smoking and salt intake and an improvement in diet [31]. The present report reveals comparable decreases in SBP and DBP but shows that changes are broadly similar in men and women, in participants treated for hypertension as well as those not, and in subgroups of age over 80 years.…”

Section: Discussionsupporting

confidence: 62%

See 1 more Smart Citation

Declining blood pressure and intensification of blood pressure management among people over 80 years

Ravindrarajah¹,

Dregan

Hazra³

et al. 2017

Journal of Hypertension

View full text Add to dashboard Cite

Background:Management of high blood pressure (BP) in people over 80 years is controversial, but there is limited information available concerning the uptake of hypertension treatment at this age.Objective:To evaluate use of antihypertensive drugs and changes in SBP and DBP from 2001 to 2014 in men and women aged 80 years and over.Methods:Cohort study using primary care electronic health records of 265 225 participants from the UK Clinical Practice Research Datalink. Records of BP and antihypertensive medications were analysed. Linear trends were estimated by frailty category in multiple regression models.Results:Data were analysed for 116 401 men and 148 824 women. The proportion with BP recorded increased from 51% in 2001 to 78% in 2014. The proportion of patients prescribed antihypertensive medications increased from 64 to 76%. Mean SBP declined from 150 (SD 20) mmHg in 2001 to 135 (16) mmHg in 2014. In ‘fit’ participants, the decline in SBP was 12.4 (95% confidence interval 11.9–13.0) mmHg/decade in those treated for hypertension and 8.5 (7.8–9.1) mmHg in those not treated. The decline in SBP was smaller as frailty increased. The proportion of all participants with BP less than 140/90 mmHg increased from 14 to 44% in the study period.Conclusion:In octogenarians, BP treatment has intensified between 2001 and 2014. BP values have declined in both treated and untreated participants, with a substantial increase in the proportion achieving conventional BP targets.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 62%

Declining blood pressure and intensification of blood pressure management among people over 80 years

Ravindrarajah¹,

Dregan

Hazra³

et al. 2017

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…[8][9][10] CVD risk factors found to be associated with aging-related phenotypes in cross-sectional analyses can differ from observed associations in longitudinal analyses.…”

mentioning

confidence: 84%

Metabolic Predictors of Change in Vascular Function

et al. 2018

View full text Add to dashboard Cite

A rterial stiffness measures predict the onset of hypertension and incident cardiovascular disease (CVD) events. [1][2][3][4][5] Cross-sectional correlates of vascular stiffness include age, sex, weight, blood pressure, height, and metabolic features like fasting glucose and lipid levels. 6 Our previous work demonstrated strong, nonlinear relations between age and aortic stiffness measures, suggesting that aortic stiffness increases over time, particularly after midlife.7 Prior work has shown that age-related trends in average values for risk factors, such as blood pressure, may include effects from aging itself, age-related changes in other risk factor levels, birth cohort effects, or other factors. [8][9][10] CVD risk factors found to be associated with aging-related phenotypes in cross-sectional analyses can differ from observed associations in longitudinal analyses.11 Therefore, we sought to assess the prospective associations of changes in large and small vessel function (as dependent variables) with changes in metabolic traits (as the independent variables) in a large community-based, multiethnic sample of middle-aged and older adults. Based on previously identified cross-sectional associations between metabolic risk factors and vascular function and between older age and worsening vascular function, we hypothesized that longitudinal worsening of metabolic traits would be associated with worsening of large and small vessel function. MethodsData, analytic methods, and study materials are available to other researchers through National Heart, Lung, and Blood Institute BioLINCC repository at https://biolincc.nhlbi.nih.gov/studies/ framcohort/. The study sample consisted of participants in the Framingham Offspring, Omni 1, Third Generation, and Omni 2 cohorts, which have been described in detail. Worsening of each metabolic trait was associated with increases in CFPWV and MAP (P<0.0001 for all associations) and an increase in MAP was associated with an increase in CFPWV. Overall, worsening metabolic traits were associated with worsening aortic stiffness and MAP. Opposite net change in aortic stiffness and MAP suggests that factors other than distending pressure contributed to the observed increase in aortic stiffness. Change in metabolic traits explained a greater proportion of the change in CFPWV and MAP than baseline metabolic values.

show abstract

“…In Norway and several other Western countries, average blood pressure has declined since the 1980s (49,50), even in those who use no antihypertensive drugs and in spite of weight gain. The reason is unknown, but a reduced intake of salt and an increased intake of fruits and vegetables, which contain a lot of potassium, may be of importance -and line with the findings in this review article.…”

Section: Discussionmentioning

confidence: 99%