Longitudinal and Transverse Right Ventricular Function in Pulmonary Hypertension: Cardiovascular Magnetic Resonance Imaging Study from the ASPIRE Registry

Swift, Andrew J.; Rajaram, Smitha; Capener, David; Elliot, Charlie; Condliffe, Robin; Wild, Jim M.; Kiely, David G.

doi:10.1086/682428

Cited by 17 publications

(12 citation statements)

References 24 publications

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“…Evidence suggests that RV longitudinal component measured by TAPSE is markedly reduced in post-cardiac surgery patients despite the absence of global RV ejection fraction decrease [17]. Recent studies with MRI suggest that RV function is reflected better by radial rather than longitudinal wall displacement in pulmonary hypertension patients [18, 19]. Pettersen and coworkers demonstrated that, after the Senning procedure (which transforms the RV to the systemic pump of the circulation), the patients have more pronounced radial component of RV function [20].…”

Section: Discussionmentioning

confidence: 99%

Quantification of the relative contribution of the different right ventricular wall motion components to right ventricular ejection fraction: the ReVISION method

Lakatos

Tősér

Tokodi

et al. 2017

Cardiovasc Ultrasound

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Three major mechanisms contribute to right ventricular (RV) pump function: (i) shortening of the longitudinal axis with traction of the tricuspid annulus towards the apex; (ii) inward movement of the RV free wall; (iii) bulging of the interventricular septum into the RV and stretching the free wall over the septum. The relative contribution of the aforementioned mechanisms to RV pump function may change in different pathological conditions.Our aim was to develop a custom method to separately assess the extent of longitudinal, radial and anteroposterior displacement of the RV walls and to quantify their relative contribution to global RV ejection fraction using 3D data sets obtained by echocardiography.Accordingly, we decomposed the movement of the exported RV beutel wall in a vertex based manner. The volumes of the beutels accounting for the RV wall motion in only one direction (either longitudinal, radial, or anteroposterior) were calculated at each time frame using the signed tetrahedron method. Then, the relative contribution of the RV wall motion along the three different directions to global RV ejection fraction was calculated either as the ratio of the given direction’s ejection fraction to global ejection fraction and as the frame-by-frame RV volume change (∆V/∆t) along the three motion directions.The ReVISION (Right VentrIcular Separate wall motIon quantificatiON) method may contribute to a better understanding of the pathophysiology of RV mechanical adaptations to different loading conditions and diseases.Electronic supplementary materialThe online version of this article (doi:10.1186/s12947-017-0100-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Quantification of the relative contribution of the different right ventricular wall motion components to right ventricular ejection fraction: the ReVISION method

Lakatos

Tősér

Tokodi

et al. 2017

Cardiovasc Ultrasound

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“…Cardiac magnetic resonance imaging (MRI) has emerged as a reliable and reproducible imaging method for assessing right heart morphology and function [6,7], including ejection fraction [31], longitudinal shortening [32], mass index [31] and work [33]. Of these parameters, ejection fraction, as assessed by cardiac MRI, has a strong prognostic value [31,34], with low right ventricular ejection fraction (RVEF) (<35%) being associated with poor survival, independent of PVR, and increases in RVEF after 12 months being predictive of improved 6-year survival [34].…”

Section: Echocardiography and Cardiac Magnetic Resonance Imagingmentioning

confidence: 99%

Risk assessment in pulmonary arterial hypertension

Raina

Humbert

2016

Eur Respir Rev

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Regular patient assessment is essential for the management of chronic diseases, such as pulmonary arterial hypertension (PAH). Comprehensive patient assessment and risk stratification in PAH are important to guide treatment decisions and to monitor disease progression as well as patients' response to treatment. Approaches for assessing risk in PAH patients include the use of risk variables, as recommended in the 2015 European Society of Cardiology (ESC)/European Respiratory Society (ERS) pulmonary hypertension (PH) guidelines, and the application of risk equations and scores, such as the French registry risk equation and the REVEAL registry risk score. Risk stratification and risk scores are both useful predictors of survival on a population basis, and provide an estimate for individual patients' risk. The 2015 ESC/ERS PH guidelines recommend regular assessment of multiple variables at an expert centre. The respective merits and limitations of different risk assessment methods in PAH are discussed in this article, as well as some considerations that can be taken into account in the future development of risk assessment tools.

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“…Retrospectively ECG gated cardiac cine imaging in the two and four chamber views allow for qualitative and quantitative assessment of the structure and function of the ventricles [57]. Segmentation of the ventricular endocardium quantifies the right and left ventricular end-diastolic and end-systolic volumes from which stroke volume and ejection fraction can be calculated.…”

Section: Cardiac Cine Mr Imagingmentioning

confidence: 99%

Current and emerging imaging techniques in the diagnosis and assessment of pulmonary hypertension

Johns

Wild

Rajaram

et al. 2018

Expert Review of Respiratory Medicine

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Pulmonary hypertension (PH) is a challenging condition to diagnose and treat. Over the last two decades, there have been significant advances in therapeutic approaches and imaging technologies. Current guidelines emphasize the importance of cardiac catheterization; however, the increasing availability of non-invasive imaging has the potential to improve diagnostic rates, whilst providing additional information on patient phenotypes. Areas covered: This review discusses the role of imaging in the diagnosis, prognostic assessment and follow-up of patients with PH. Imaging methods, ranging from established investigations (chest radiography, echocardiography, nuclear medicine and computerized tomography (CT)), to emerging modalities (dual energy CT, magnetic resonance imaging (MRI), optical coherence tomography and positron emission tomography (PET)) are reviewed. The value and limitations of the clinical utility of these imaging modalities and their potential clinical application are reviewed. Expert commentary: Imaging plays a key role in the diagnosis and classification of pulmonary hypertension. It also provides valuable prognostic information and emerging evidence supports a role for serial assessments. The authors anticipate an increasing role for imaging in the pulmonary hypertension clinic. This will reduce the need for invasive investigations, whilst providing valuable insights that will improve our understanding of disease facilitate a more targeted approach to treatment.

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Longitudinal and Transverse Right Ventricular Function in Pulmonary Hypertension: Cardiovascular Magnetic Resonance Imaging Study from the ASPIRE Registry

Cited by 17 publications

References 24 publications

Quantification of the relative contribution of the different right ventricular wall motion components to right ventricular ejection fraction: the ReVISION method

Quantification of the relative contribution of the different right ventricular wall motion components to right ventricular ejection fraction: the ReVISION method

Risk assessment in pulmonary arterial hypertension

Current and emerging imaging techniques in the diagnosis and assessment of pulmonary hypertension

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