Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

Tedeschi, Enrico; Cocozza, Sirio; Borrelli, Pasquale; Ugga, Lorenzo; Morra, Vincenzo Brescia; Palma, Giuseppe

doi:10.2463/mrms.cr.2016-0137

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…Another quantitative MRI approach that has been successfully applied and warrants further exploration is T1/T2 relaxometry. [28][29][30][31] A strength of this proof-of-concept study is that the enrolled MS cohort had received a relatively high number of GBCA administrations, increasing the likelihood of being able to demonstrate dose-dependent associations to MRI signal abnormalities. Another strength is the existence of a well-matched healthy control group without any GBCA administrations.…”

Section: Number Of Gbca Administrationsmentioning

confidence: 99%

“…T1-and T2-relaxometry of the DN and GP has been reported as robust quantitative methods for this purpose. [28][29][30][31] Quantitative susceptibility mapping (QSM), based on paramagnetic effects of gadolinium, also captures signal changes in the DN following multiple GBCA administrations and has recently been shown to outperform T1-weighted imaging. 32,33 Magnetization transfer (MT) is another quantitative MRI technique that may have a meaningful role in the evaluation of gadolinium retention.…”

Section: Introductionmentioning

confidence: 99%

“…The challenges of detecting subtle GBCA‐related MRI signal changes have, however, sparked an interest in using nonconventional MRI methods to quantify such abnormalities. T1‐ and T2‐relaxometry of the DN and GP has been reported as robust quantitative methods for this purpose 28–31 . Quantitative susceptibility mapping (QSM), based on paramagnetic effects of gadolinium, also captures signal changes in the DN following multiple GBCA administrations and has recently been shown to outperform T1‐weighted imaging 32,33 …”

Section: Introductionmentioning

confidence: 99%

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MRI detection of brain gadolinium retention in multiple sclerosis: Magnetization transfer vs. T1‐weighted imaging

Cananau

Forslin

Bergendal

et al. 2023

Journal of Neuroimaging

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Background and Purpose Evidence of brain gadolinium retention has affected gadolinium‐based contrast agent usage. It is, however, unclear to what extent macrocyclic agents are retained and whether their in vivo detection may necessitate nonconventional MRI. Magnetization transfer (MT) could prove suitable to detect gadolinium‐related signal changes since dechelated gadolinium ions bind to macromolecules. Therefore, this study aimed to investigate associations of prior gadolinium administrations with MT and T1 signal abnormalities. Methods A cohort of 23 persons with multiple sclerosis (MS) (18 females, 5 males, 57 ± 8.0 years) with multiple past gadolinium administrations (median 6, range 3‐12) and 23 age‐ and sex‐matched healthy controls underwent 1.5 Tesla MRI with MT, T1‐weighted 2‐dimensional spin echo, and T1‐weighted 3‐dimensional gradient echo. The signal intensity index was assessed by MRI in gadolinium retention predilection sites. Results There were dose‐dependent associations of the globus pallidus signal on gradient echo (r = .55, p < .001) and spin echo (r = .38, p = .013) T1‐weighted imaging, but not on MT. Relative to controls, MS patients had higher signal intensity index in the dentate nucleus on T1‐weighted gradient echo (1.037 ± 0.040 vs. 1.016 ± 0.023, p = .04) with a similar trend in the globus pallidus on T1‐weighted spin echo (1.091 ± 0.034 vs. 1.076 ± 0.014, p = .06). MT detected no group differences. Conclusions Conventional T1‐weighted imaging provided dose‐dependent associations with gadolinium administrations in MS, while these could not be detected with 2‐dimensional MT. Future studies could explore newer MT techniques like 3D and inhomogenous MT. Notably, these associations were identified with conventional MRI even though most patients had not received gadolinium administrations in the preceding 9 years, suggestive of long‐term retention.

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Section: Number Of Gbca Administrationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MRI detection of brain gadolinium retention in multiple sclerosis: Magnetization transfer vs. T1‐weighted imaging

Cananau

Forslin

Bergendal

et al. 2023

Journal of Neuroimaging

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“…The qMRI of the brain offers a unique opportunity to characterize the pathophysiology patterns of neuroinflammation [13][14][15] and neurodegeneration [16,17], traumatic brain injury [18] and anomalies of the deep venous system [19,20], tumors [21] and their progression [22], RT response [23,24] and toxicity [25], in a way that proves highly independent from the scanner and the imaging protocol and, as such, particularly suitable for longitudinal [26,27] and multi-center [28] studies or outcome modeling [29,30].…”

Section: Introductionmentioning

confidence: 99%

RESUME : A flexible class of multi-parameter qMRI protocols

et al. 2021

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To introduce a class of fast 3D quantitative MRI (qMRI) schemes (RESUME N , for N = 1,…, 4) that allow for a thorough characterization of microstructural properties of brain tissues. Methods: An arbitrary multi-echo GRE acquisition optimized for quantitative susceptibility mapping (QSM) is complemented with an appropriate low flip-angle GRE sequence drawn from four possible choices. The acquired signals are processed to analytically derive the longitudinal relaxation (R 1 ) and free induction decay (R * 2 ) rates, as well as the proton density (PD) and QSM. A comprehensive modeling of the excitation and B − 1 profiles and of the RF-spoiling is included in the acquisition and processing pipeline. Results: The RESUME N maps appear homogeneous throughout the field-of-view and exhibit comparable values and high SNR across the considered range of N values. Conclusions: The introduced schemes represent a class of robust and flexible strategies to derive a thorough and fast qMRI study, suitable for a whole-brain acquisition with isotropic voxel resolution of 700 μm in less than 15 min.

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“…In [ 27 ], PD was used to derive Macromolecular Tissue Volume Fraction (MTVF) maps, which provide a sensitive measure of the disease status in multiple sclerosis patients, and, together with R 1 maps, allow for an estimation of the apparent volume of interacting water protons (strictly related to the properties of local physico-chemical environment). Moreover, R 1 , coupled to , is a key to determine the stage of haemorrhages [ 28 ] or to obtain absolute measures of contrast agent concentrations within tissues [ 29 , 30 ]. In addition, the joint availability of R 1 , and susceptibility measures in Fabry’s disease has been recently exploited to redefine the pathogenetic mechanisms and the incidence of the pulvinar sign in that metabolic disorder [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

RESUME: Turning an SWI acquisition into a fast qMRI protocol

et al. 2017

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Susceptibility Weighted Imaging (SWI) is a common MRI technique that exploits the magnetic susceptibility differences between the tissues to provide valuable image contrasts, both in research and clinical contexts. However, despite its increased clinical use, SWI is not intrinsically suitable for quantitation purposes. Conversely, quantitative Magnetic Resonance Imaging (qMRI) provides a way to disentangle the sources of common MR image contrasts (e.g. proton density, T1, etc.) and to measure physical parameters intrinsically related to tissue microstructure. Unfortunately, the poor signal-to-noise ratio and resolution, coupled with the long imaging time of most qMRI strategies, have hindered the integration of quantitative imaging into clinical protocols. Here we present the RElaxometry and SUsceptibility Mapping Expedient (RESUME) to show that the standard acquisition leading to a clinical SWI dataset can be easily turned into a thorough qMRI protocol at the cost of a further 50% of the SWI scan time. The R1, , proton density and magnetic susceptibility maps provided by the RESUME scheme alongside the SWI reconstruction exhibit high reproducibility and accuracy, and a submillimeter resolution is proven to be compatible with a total scan time of 7 minutes.

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Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

Cited by 10 publications

References 25 publications

MRI detection of brain gadolinium retention in multiple sclerosis: Magnetization transfer vs. T1‐weighted imaging

MRI detection of brain gadolinium retention in multiple sclerosis: Magnetization transfer vs. T1‐weighted imaging

RESUME : A flexible class of multi-parameter qMRI protocols

RESUME: Turning an SWI acquisition into a fast qMRI protocol

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