Longitudinal assessment of health related quality of life of HIV infected patients treated for tuberculosis and HIV in a high burden setting

Mthiyane, Thuli; Pym, Alex; Dheda, Keertan; Rustomjee, Roxana; Reddy, Tarylee; Manie, Shamila

doi:10.1007/s11136-016-1332-4

Cited by 6 publications

(12 citation statements)

References 35 publications

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“…In contrast, a study from South Africa reported greater impairment in physical functioning, but better mental health, among TB/HIV co-infected patients [46]. Another study from South Africa showed overall improvement in QOL with therapy in TB/HIV coinfected patients [47]. This improvement appeared similar among those receiving, and not receiving concomitant anti-retroviral therapy.…”

Section: Tb and Human Immunodeficiency Virus (Hiv) Co-infectionmentioning

confidence: 88%

“…This 26-item instrument evaluates QOL across four domains – Physical, Psychological, Social relationships, and Environment. Some other generic scales used include Medical Outcome Survey (MOS) [9] Social Functioning 12 (SF-12) [32,43], variants of the WHOQOL scale family [19,44,45], and other uncommon or in-house instruments [46], [47], [48].…”

Section: Instruments For Describing and Quantifying Qol In Tbmentioning

confidence: 99%

“…[43]Primary care clinics in South Africa1196 patients with TBNR36.8%NoneSF-12Baseline, 6 monthsMthiyane et al. [47]Hospitals in South Africa62TB/HIV coinfected patients100%Excluded20 HIV+ patientsFAHIBaseline, 3 months, 6 months, 12 monthsKastien-Hilka et al. [32]Primary care clinics in South Africa131 patients with pulmonary TBNone20.6%NoneSF-12, EQ-5D, SGRQST, 4, 8, 16 weeks, ETRamkumar et al.…”

Section: Effect Of Treatmentmentioning

confidence: 99%

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Quality of life with tuberculosis

Aggarwal

2019

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Tuberculosis diagnosis and treatment currently revolves around clinical features and microbiology. The disease however adversely affects patients’ psychological, economic, and social well-being as well, and therefore our focus also additionally needs to shift towards quality of life (QOL). The disease influences all QOL domains and substantially adds to patient morbidity, and these complex and multidimensional interactions pose challenges in accurately quantifying impairment in QOL. For this review, PubMed database was queried using keywords like quality of life, health status and tuberculosis, and additional publications identified by a bibliographic review of shortlisted articles. Both generic and specific QOL scales show a wide variety of derangements in scores, and results vary across countries and patient groups. In particular, diminished capacity to work, social stigmatization, and psychological issues worsen QOL in patients with tuberculosis. Although QOL has been consistently shown to improve during standard anti-tubercular therapy, many patients continue to show residual impairment. It is also not clear if specific situations like presence of comorbid illnesses, drug resistance, or co-infection with human immunodeficiency virus additionally worsen QOL in these patients. There is a definite need to incorporate QOL assessment as adjunct outcome measures in tuberculosis control programs. Governments and program managers need to step up socio-cultural reforms and health education, and provide additional incentives to patients, to counter impairment in QOL.

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Section: Tb and Human Immunodeficiency Virus (Hiv) Co-infectionmentioning

confidence: 88%

Section: Instruments For Describing and Quantifying Qol In Tbmentioning

confidence: 99%

Section: Effect Of Treatmentmentioning

confidence: 99%

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Quality of life with tuberculosis

Aggarwal

2019

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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“…The 15 selected articles were published between 2009 and 2019, being two publications in 2009 (13)(14) , four in 2012 (7)(8)(15)(16) , three in 2013 (17,19) , one in 2014 (20) , one in 2015 (21) , one in 2016 (22) , two in 2018 (23)(24) and one in 2019 (25) . As for the journal, the articles have been published in 13 different ones, with emphasis on Health and Quality of Life Outcomes (14,16) and The International Journal of Tuberculosis and Lung Disease (19,20), with two publications each.…”

Section: Resultsmentioning

confidence: 99%

Tuberculosis/HIV coinfection from the perspective of quality of life: scope review

et al. 2021

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Objectives: to analyze evidence on the quality of life of people with tuberculosis/HIV coinfection. Methods: review that followed steps of the Cochrane Collaboration, with the search of publications in the bases Embase, LILACS, PubMed, and Cochrane, through the descriptors “HIV,” “Tuberculosis,” and “Quality of Life,” without a temporal cut. Results: the results include 15 studies, published between 2009 and 2019, with the level of evidence V, in its majority. It was observed that there is no uniformity in the instrument used. Psychological support to this group and strengthening of actions to manage both infections are necessary. This segment’s quality of life is associated with social factors and scientific production on the subject concentrated in underdeveloped countries. Conclusions: the articles found have a low level of scientific evidence and indicate that people who experience coinfection have a more compromised quality of life when compared to those who experience tuberculosis or HIV separately.

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“…Tuberculosis can significantly reduce individuals’ QOL (Brown et al 2015; Guo, Marra & Marra 2009), but QOL can improve over time with successful TB management (Guo et al 2009; Mthiyane et al 2016). An issue that may contribute to the reduction in QOL is the effect that PTB has on individuals’ lung function.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with physical function capacity in an urban cohort of people living with the human immunodeficiency virus in South Africa

Roos

Myezwa

Aswegen

2019

S. Afr. j. physiother.

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Background: Effective disease management for people living with human immunodeficiency virus (PLWH) includes the encouragement of physical activity. Physical function capacity in PLWH may be influenced by a variety of factors.Objectives: This study describes the physical function capacity as assessed with the 6-minute walk test (6MWT) of an urban cohort of PLWH and determined whether a history of pulmonary tuberculosis (PTB), anthropometric measures, age and gender predicted distance walked.Method: Secondary data collected from 84 PLWH on antiretroviral therapy were analysed. Information included 6MWT distance, anthropometric measurements and demographic profiles. Descriptive and inferential statistics were undertaken on the data. A regression analysis determined predictive factors for 6MWT distance achieved. Significance was set at a p-value of ≤ 0.05.Results: The study consisted of 66 (78.6%) women and 18 (21.4%) men with a mean age of 39.1 (± 9.2) years. The 6MWT distance of the cohort was 544.3 (± 64.4) m with men walking further (602.8 [± 58.6] m) than women (528.3 [± 56.4] m); however, women experienced greater effort. The majority of the sample did not report a history of PTB (n = 67; 79.8%). Age, gender and anthropometric measures were associated with 6MWT distance, but of low to moderate strength. The regression equation generated included age and gender. This model was statistically significant (p 0.00) and accounted for 34% of the total variance observed.Conclusion: Age and gender were predictive factors of physical function capacity and women experienced greater effort.Clinical implications: This study provides information on the physical function capacity of PLWH and a suggested 6MWT reference equation for PLWH in South Africa.

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Longitudinal assessment of health related quality of life of HIV infected patients treated for tuberculosis and HIV in a high burden setting

Cited by 6 publications

References 35 publications

Quality of life with tuberculosis

Quality of life with tuberculosis

Tuberculosis/HIV coinfection from the perspective of quality of life: scope review

Factors associated with physical function capacity in an urban cohort of people living with the human immunodeficiency virus in South Africa

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